Browsing by Publisher "Turkish Neuropsychiatric Society"
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Item New delirium rating scale for ICU; [yoǧun bakım olgularinda yeni deliryum deǧerlendirme skalası](Turkish Neuropsychiatric Society, 2010) Ok G.; Aydemir O.; Tok D.; Erbüyün K.; Turan E.Objective: The New Delirium Rating Scale (NDRS) makes use of verbal assessments to evaluate the cardinal features of delirium and is an observer-rated, 10-item symptom rating scale based on both DSM-IV and the findings of the previous clinical research. In this study, we tested the validity of the NDRS for measuring the severity of delirium in intensive care units. Methods: Thirty consecutive non-intubated patients admitted to the ICU for more than 24 hours were included in the study. Two intensivists were trained to rate delirium according to NDRS and they daily carried out structured interviews to evaluate the patients. All patients were interviewed by a psychiatrist for rating according to NDRS, and the data collected by the psychiatrist and the intensivists were compared. Results: The cut-off score for NDRS was 11.3 patients (10%), who were rated as delirious. The inter-rater reliability of the intensivists and the psychiatrist was found to be 0.84 and 0.90, respectively (p<0.0001). Conclusion: Intensivists easily used NDRS, a detailed delirium assessing scale, and rated delirium successfully. © Archives of Neuropsychiatry, published by Galenos Publishing.Item Should the western aphasia battery be translated into Turkish?; [Western afazi bataryası Türkçe'ye çevrilmeli mi?](Turkish Neuropsychiatric Society, 2010) Dönmez Keklikoǧlu H.; Selçuki D.; Keskin S.Objective: Aphasia tests are used to classify and diagnose aphasia. Aphasia tests, which can classify aphasia quantitatively, are needed for a standard classification of aphasia and to compare studies performed in different centers. The aim of this study was to assess the feasibility of the Turkish version of the Western Aphasia Battery (WAB), which classifies aphasia quantitatively, in Turkish speaking patients with aphasia. Methods: This study consisted of two stages. In the first stage, WAB was translated and adapted into Turkish. The Frenchay Aphasia Screening Test-Turkish (FAST) and Gulhane Aphasia Test (GAT) were applied to 20 aphasic patients in the second stage. Test results and lesion localizations were evaluated. Results: Two patients, who were found to be normal according to FAST, were evaluated to be aphasic according to the other tests. There was a high degree of correlation between the WAB-Turkish and the GAT scores. The results of the two tests regarding the lesion localization were also similar. The only difference was in the classification of aphasia. Conclusion: The difference in aphasia classification may be due to the personal interpretation of the test administrator during GAT aphasia classification or lack of a WAB standardization study. A standardization study for the Turkish version of WAB will be useful for studies on evaluation and classification of aphasia. © Archives of Neuropsychiatry, published by Galenos Publishing.Item Validity and reliability of the QIDS-SR16-Turkish in comparison with BDI-IITurkish among young outpatient sample of Turkish University students; [Hızlı Depresif Belirti Envanteri-Özbildirim Formu'nun (HDBE 16 -ÖF) Beck Depresyon Envanteri-II ile Karşılaştırılarak Ayaktan Başvuran Hastalarda Geçerlilik ve Güvenilirliǧi](Turkish Neuropsychiatric Society, 2012) Mergen H.; Tavli T.; Öngel K.Objective: To evaluate the validity and reliability of 16-item self-report version of the Quick Inventory of Depressive Symptomatology (QIDS-SR16) scale in comparison with BDI-II-Turkish (BDI-II-T) in a young sample of Turkish university students. Methods: A slightly modified version of the QIDS-SR16-Turkish (QIDS-SR16-T) available at www.ids-qids.org, along with the BDI-II-T, was administered to 628 young Turkish university students who attended the Family Health Center in Uludaǧ University Campus between February and April 2010. Descriptive analyses, Student's t-test, receiver operating characteristic (ROC) analysis, and confirmatory factor analyses were used in the study. Results: The mean age of the participants was 21.1±2.16 (SD) years; 67.8% were female and 32.2% were male. Cronbach's α coefficient for internal consistency of the QIDS-SR16-T was found to be 0.769. The mean item-total correlation was 0.45, ranging from 0.29 to 0.71. The correlation between the BDI-II-T and QIDS-SR16-T was 0.72. ROC curve analysis suggested 9 as the optimal cut-off for a clinical depression level for the QIDS-SR16-T. Conclusion: We observed that the QIDS-SR16-T demonstrated good psychometric properties in a sample of young Turkish students and has convergent validity with the BDI-II-T, a widely used scale for depression. It is essential to diagnose reliably the major depressive disorder and to follow up the patients by valid screening instruments in primary care setting. The internal consistencies of the QIDS determined in studies from the United States were greater than our Cronbach's α coefficient, but there was no statistically significant difference between them (z=0.55, p>0.05). The QIDS-SR16-T can be reliably used in primary care settings. © Archives of Neuropsychiatry, published by Galenos Publishing.Item Reliability and validity of the Turkish version of the Burden assessment scale; [Hastalık yükü deǧerlendirme ölçeǧi'nin türkçe sürümünün güvenilirlik ve geçerliliǧi](Turkish Neuropsychiatric Society, 2012) Aydemir Ö.; Sücüllüoǧlu Dikici D.; Akdeniz F.; Kalayci F.Background: In this study, it is aimed to evaluate the reliability and validity of the Turkish version of the Burden Assessment Scale. Methods: The study was carried out on 100 volunteers who were caregivers of in- or outpatients at a university hospital, department of psychiatry. The diagnoses of the patients were schizophrenia (25%), bipolar disorder (22%), major depressive disorder (24%), and anxiety disorder (29%). The mean duration of the illness was 8.2±8.7 years. For the concurrent validity, the Perceived Family Burden Scale and the Zarit Caregiver Burden Scale were used. In the statistical analyses, internal consistency, item-total score correlation, explorative factor analysis, correlation with other scales were calculated. Results: The Turkish version of the Burden Assessment Scale was prepared after the translation and back-translation of the original scale and after the consensus on the translated form. In the internal consistency analysis, Cronbach alpha coefficient was found to be 0,894 and item-total score correlation coefficients were between 0.297 and 0.742. In the explorative factor analysis, a five-factor solution explaining 67.2% of the total variance was obtained and the conceptual themes of the factors were limitations in daily life, negative emotions, worry for the patient, losses of the caregiver, and disruption in activities. The correlation of the Burden Assessment Scale with the Perceived Family Burden Scale was r=0.485 and with the Zarit Caregiver Burden Scale was r=0.610. Conclusion: It is demonstrated that the Turkish version of the Burden Assessment Scale which is convenient in the milder forms of psychiatric disorders and which is developed for the assessment burden of patients on their caregivers is reliable and valid. © Archives of Neuropsychiatry, published by Galenos Publishing.Item Reliability and validity study of the Turkish version of the clinical opiate clinical scale; [Klinik opiyat yoksunluk ölçeği (clinical opiate withdrawal scale-cows) Türkçe sürümünün güvenilirliği ve geçerliliği](Turkish Neuropsychiatric Society, 2015) Altintoprak A.E.; Evren E.C.; Aydemir Ö.; Yapici-Eslek A.; Can Y.; Mutlu E.; Tokuçoğlu L.; Deveci A.; Coşkunol H.Introduction: The aim of the present study was to perform reliability and validity analyses of the Turkish version of the Clinical Opiate Withdrawal Scale which is used to determine the severity of opiate withdrawal. Methods: Initially, the Clinical Opiate Withdrawal Scale (COWS) was translated into Turkish and subsequently back-translated into English. The originality of the back-translated version was approved by the author who developed the scale. After the translation was completed, the scale was used to assess the withdrawal symptoms of 100 patients with opiate withdrawal and 41 patients with alcohol withdrawal. Cronbach’s alpha was used in the reliability assessment; explanatory and confirmatory factor analyses were used in structural validity assessment; and in scale validity, ROC analysis was used among diagnosis groups. Results: The Cronbach’s alpha internal consistency coefficient was calculated as 0.74 in reliability analyses. The correlation coefficient was found to be 0.975 (p<0.001) for inter-rater reliability. Factor analysis was conducted for the structural validity of the scale and findings that support the unidimensional structure of the scale were observed. In the confirmatory factor analysis, CFI, GFI and RMSEA values were found to be 0.905, 0.905 and 0.079, respectively. It was detected that COWS was successful in distinguishing between opiate and alcohol withdrawal symptoms and the area under the ROC curve was 0.878. Conclusion: This study showed that the Turkish version of COWS can be used reliably and validly for assessing opiate withdrawal. © 2015 by Turkish Association of Neuropsychiatry.Item Effects of depression on treatment motivation in male alcohol dependence(Turkish Neuropsychiatric Society, 2015) Cengısız C.; Devecı A.; Yapici A.Introduction: Treatment motivation in alcohol dependents is usually viewed as a strong predictor of seeking treatment and treatment success. The conditions affecting motivation in alcohol dependence, however, has not been clarified. In this study, it is aimed to determine the effects of depression on treatment motivation in male alcohol dependence. Methods: The present study included 34 male alcohol dependents presenting to outpatient clinics in Manisa Hospital of Mental Disorders and Hospital of Celal Bayar University. The patients underwent evaluation using the socio-demographic and clinical information form, DSM-IV SCID-I Clinical Version, Treatment Motivation Questionnaire (TMQ), and Hamilton Depression Rating Scale (HDRS). Results: A significant relationship was found between the total score of TMQ and HDRS (p=.039). Conclusion: We believe that the present study, in which we examined the relationship between treatment motivation in male alcohol dependence and depression, would provide a significant contribution to literature. It is also important to investigate other factors that may affect treatment motivation in male alcohol dependence. Studies with larger samples are needed on this topic. © 2015 by Turkish Association of Neuropsychiatry.Item The Turkish adaptation, validity, and reliability of the internal states scale; [İçsel Durum Ölçeği’nin Türkçeye Uyarlaması, Geçerlik ve Güvenirlik Çalışması](Turkish Neuropsychiatric Society, 2016) Maçkali Z.; Akkaya C.; Aydemir Ö.Introduction: The Internal State Scale (ISS) was developed to simultaneously assess manic and depressive symptoms in bipolar disorder. In the present study, the validity and reliability of the Turkish version of ISS (ISS-TR) were examined. The present study aimed to present the psychometric properties of this scale. Methods: The sample consisted of 200 outpatients with bipolar disorder and 49 healthy controls. Participants completed the Turkish Internal State Scale (ISS-TR), the Brief Psychiatric Rating Scale (BPRS), the Hamilton Depression Rating Scale (HDRS), and the Young Mania Rating Scale (YMRS). Results: Reliability analyses revealed that the Cronbach alfa coefficient of ISS was 0.88 for the whole sample. Item-total correlations ranged from 0.15 to 0.78. Two factors emerged as a result of factor analysis: “mania” and “depression-well-being.” Test–retest correlations were determined for the mania subscale as r=0.654, p<0.01 and for the depression-well-being subscale as r=0.356, p<0.01. The correlations between BPRS and both subscales were quite high. The correlation between HDRS and the depression-well-being subscale was higher (r=0.475) than that between HDRS and the mania subscale, whereas the correlation between YMRS and the mania subscale was higher (r=0.818) than that between YMRS and the depression-well-being subscale. It was seen that ISS could discriminate between the clinical and healthy control samples. In addition, it was observed that the mania subscale predicted a manic period more strongly, while the depression- well-being subscale predicted a depressive period better. Conclusion: ISS is a valid and reliable scale that can be used to simultaneously assess manic and depressive symptoms. It is thought that ISS will be useful in the recognition of prodromal symptoms and in the process of maintenance treatment. © 2016 by Turkish Association of Neuropsychiatry.Item Community mental health services: Quo vadis?(Turkish Neuropsychiatric Society, 2016) Soygür H.[No abstract available]Item Validity and reliability of the Turkish version of the DSM-5 posttraumatic stress symptom severity scale-child form(Turkish Neuropsychiatric Society, 2017) Yalin Sapmaz Ş.; Ergin D.; Özek Erkuran H.; Şen Celasin N.; Öztürk M.; Karaarslan D.; Köroğlu E.; Aydemir Ö.Introduction: This study assessed the validity and reliability of the Turkish version of the DSM-5 Posttraumatic Stress Symptom Severity Scale-Child Form for use among the Turkish population. Methods: The study group consisted of 30 patients that had been treated in a child psychiatry unit and diagnosed with posttraumatic stress disorder and 83 healthy volunteers that were attending middle or high school during the study period. For reliability analyses, the internal consistency coefficient and the test-retest correlation coefficient were measured. For validity analyses, the exploratory factor analysis and correlation analysis with the Child Posttraumatic Stress Reaction Index for concurrent validity were measured. Results: The Cronbach’s alpha (the internal consistency coefficient) of the scale was 0.909, and the test-retest correlation coefficient was 0.663. One factor that could explain 58.5% of the variance was obtained and was congruent with the original construct of the scale. As for concurrent validity, the scale showed high correlation with the Child Posttraumatic Stress Reaction Index. Conclusion: It was concluded that the Turkish version of the DSM-5 Posttraumatic Stress Symptom Severity Scale- Child Form can be used as a valid and reliable tool. © 2017 by Turkish Association of Neuropsychiatry.Item Validity and reliability of the Turkish version of DSM-5 social anxiety disorder severity scale- child form(Turkish Neuropsychiatric Society, 2017) Yalın Sapmaz Ş.; Ergın D.; Şen Celasın N.; Karaarslan D.; Öztürk M.; Özek Erkuran H.; Köroğlu E.; Aydemır Ö.Introduction: This study aimed to assess the validity and reliability of the Turkish version of the Diagnostic and statistical manual of Mental Disorders. (5th ed.) (DSM-5) Social Anxiety Disorder Severity Scale - Child Form. Method: The scale was prepared by carrying out the translation and back translation of the DSM-5 Social Anxiety Disorder Severity Scale - Child Form. The study group consisted of 31 patients that had been treated in a child psychiatry unit and diagnosed with social anxiety disorder and 99 healthy volunteers that were attending middle or high school during the study period. For the assessment, the Screen for Child Anxiety and Related Emotional Disorders (SCARED) was also used along with the DSM-5 Social Anxiety Disorder Severity Scale - Child Form Results: Regarding reliability analyses, Cronbach’s alpha internal consistency coefficient was calculated as 0.941, while item-total score correlation coefficients were measured between 0.566 and 0.866. A test-retest correlation coefficient was calculated as r=0.711. As for construct validity, one factor that could explain 66.0 % of the variance was obtained. As for concurrent validity, the scale showed a high correlation with the SCARED. Conclusion: It was concluded that the Turkish version of the DSM-5 Social Anxiety Disorder Severity Scale - Child Form could be utilized as a valid and reliable tool both in clinical practice and for research purposes. © 2017 by Turkish Association of Neuropsychiatry.Item Validity and reliability of the turkish version for DSM-5 level 2 anger scale (child form for children aged 11-17 years and parent form for children aged 6-17 years)(Turkish Neuropsychiatric Society, 2017) Yalın Sapmaz Ş.; Özek Erkuran H.; Yalin N.; Önen Ö.; Öztekın S.; Kavurma C.; Köroğlu E.; Aydemır Ö.Introduction: This study aimed to assess the validity and reliability of the Turkish version of Diagnostic and Statistical Manual of Mental Disorders (DSM-5) Level 2 Anger Scale. Methods: The scale was prepared by translation and back translation of DSM-5 Level 2 Anger Scale. Study groups consisted of a clinical sample of cases diagnosed with depressive disorder and treated in a child and adolescent psychiatry unit and a community sample. The study was continued with 218 children and 160 parents. In the assessment process, child and parent forms of DSM-5 Level 2 Anger Scale and Children’s Depression Inventory and Strengths and Difficulties Questionnaire-Parent Form were used. Results: In the reliability analyses, the Cronbach alpha internal consistency coefficient values were found very high regarding child and parent forms. Item-total score correlation coefficients were high and very high, respectively, for child and parent forms indicating a statistical significance. As for construct validity, one factor was maintained for each form and was found to be consistent with the original form of the scale. As for concurrent validity, the child form of the scale showed significant correlation with Children’s Depression Inventory, while the parent form showed significant correlation with Strengths and Difficulties Questionnaire-Parent Form. Conclusion: It was found that the Turkish version of DSM-5 Level 2 Anger Scale could be utilized as a valid and reliable tool both in clinical practice and for research purposes. © 2017 by Turkish Association of Neuropsychiatry.Item Validity and reliability of the Turkish version of DSM-5 level 2 anxiety scale (Child form for 11-17 years and parent form for 6-17 years)(Turkish Neuropsychiatric Society, 2018) Yalin Sapmaz Ş.; Özek Erkuran H.; Karaarslan D.; Öztürk M.; Yörük Ülker G.; Serim Demirgören B.; Köroğlu E.; Aydemir Ö.Introduction: This study aimed to assess the validity and reliability of the Turkish Version of DSM-5 Level 2 Anxiety Scale’s child and parent forms. Methods: The scale was constructed by carrying out the translation and back translation of DSM-5 Level 2 Anxiety Scale. The study group consisted of a community and clinical sample. The scale was applied to 148 parents and 189 adolescents that represented the clinical and community sample. During the assessment process, Screen for Childhood Anxiety Related Emotional Disorders and Strengths and Difficulties Questionnaire-Parent Form were also used. Results: Reliability analyses indicated a high internal consistency regarding Level 2 Anxiety Scales, both for child and parent forms (0.915/0.933). In the meantime, it was shown that child form for Level 2 Anxiety Scale was significantly correlated with Screen for Childhood Anxiety Related Emotional Disorders (r=0.758, p<0.0001) while the parent form was significantly correlated with Strengths and Difficulties Questionnaire-Parent Form (r=0.717, p<0.0001). As for the content validity, one factor was obtained for both forms, and it was observed to be consistent with the original construct of the scale. Conclusion: It was concluded that Turkish version of DSM-5 Level 2 Anxiety Scale was a valid and reliable tool to be utilized both for clinical practice, and research purposes. © 2016 by Turkish Association of Neuropsychiatry.Item DSM-5 level 2 sleep disorders scale validity and reliability of Turkish form (Form for children aged 11–17 years and parent form for children aged 6–17 years)(Turkish Neuropsychiatric Society, 2018) Erkuran H.Ö.Z.E.K.; Yalin Sapmaz Ş.; Herdem A.; Öztürk M.; Bilaç Ö.; Önen Ö.; Uzel Tanriverdi B.; Köroğlu E.; Aydemir Ö.Introduction: This study aimed to assess the validity and reliability of Turkish version of DSM-5 Level 2 Sleep Disorders Scale. Method: The scale was prepared by translation and back translation of DSM-5 Level 2 Sleep Disorders Scale. Study groups consisted of a clinical sample that contained cases that had sleep related problems and treated in a child and adolescent psychiatry unit and also a community sample. In the assessment process, child and parent forms of DSM-5 Level 2 Sleep Disorders Scale and also Children’s Sleep Habits Questionnaire-Turkish version (CSHQ) and Pittsburgh Sleep Quality Index (PSQI) were used. As for reliability analyses, internal consistency coefficient and item-total score correlation analysis, test-retest reliability; and for validity analyses, explanatory factor analysis and for concurrent validity, correlation analyses with Children’s Sleep Habits Questionnaire-Turkish version (CSHQ) and Pittsburgh Sleep Quality Index (PSQI) were made. Results: In reliability analyses, Cronbach’s alpha internal consistency coefficient values were found to be very highly reliable regarding child and parent forms. Item-total score correlation coefficients were high for child form while medium and high for parent form; indicating a statistical significance. As for construct validity, two factors were maintained that would count for 74.1% of the variance in child form and 66.9% of the variance in parent form. It was seen that positive and negative statements weighed on two different factors. As for concurrent validity, child and parent form of the scale showed significant correlation with Children’s Sleep Habits Questionnaire-Turkish version (CSHQ) and Pittsburgh Sleep Quality Index (PSQI). Conclusion: It was found that Turkish version of DSM-5 Level 2 Sleep Disorders Scale could be utilized as a valid and reliable tool both in clinical practice and for research purposes. © 2017 by Turkish Association of Neuropsychiatry.Item Adaptation of the dementia attitudes scale into turkish(Turkish Neuropsychiatric Society, 2020) Çetinkaya A.; Elbi H.; Altan S.; Rahman S.; Aydemir Ö.Introduction: The aim of this study was to assess psychometric properties of the Turkish version of the Dementia Attitudes Scale which is developed to determine attitudes towards dementia. Methods: 326 volunteered students between the age of 20–44 years, studying in Manisa Celal Bayar University Faculty of Medicine and Faculty of Health Sciences are included in this methodological study. Data of the study were collected with “Demographic Data Form”, “Dementia Attitudes Scale” and “UCLA-Geriatrics Attitudes Scale”. For the analysis of the data, the SPSS and Lisrel software were used. Results: The Cronbach’s alpha coefficient of the Dementia Attitudes Scale is 0.84 which is quite high. Confirmatory factor analysis has supported three factor-structure of the scale: “Supporting attitude”, “Accepting attitude” and “Exclusionary attitude”. Confirmatory factor analysis revealed goodness of fit coefficients as 0.076 for RMSEA, 2.86 for the chi-square/sd, and 0.93 for CFI. The analysis showed that the adapted scale fits the model very well. The scale can discriminate between demographic characteristics and attitudes to dementia. The scale significantly correlates with UCLA-Geriatric Attitudes Scale measuring attitude towards the elderly. Conclusion: Dementia Attitude Scale is a valid and reliable scale that can be used in studies evaluating the attitude towards dementia. © 2019 by Turkish Association of Neuropsychiatry.Item Seasonality in bipolar disorder: Impact on mood symptoms, psychosocial functioning, neurocognition, and biological rhythm; [Bipolar Bozuklukta Mevsimsellik: Duygudurum Belirtilerine, Psikososyal İşlevselliğe, Nörokognisyon ve Biyolojik Ritim Üzerine Etkisi](Turkish Neuropsychiatric Society, 2021) Çökmüş F.P.; Aşçibaşi K.; Sücüllüoğlu Dikici D.; Çöldür E.Ö.; Avci E.; Aydemir Ö.Introduction: Even though an increase in the number of hospital admissions for manic and depressive periods at certain times of the year is reported in bipolar disorder (BD), mood symptoms do not show a seasonal variation. We aimed to find out the possible causes of increased hospital admissions of BD patients in certain periods of the year. Methods: The study was carried out in four centers in Turkey. The patient group consisted of 41 persons with a diagnosis of BD in remission. The healthy control (HC) group consists of 37 persons. The selected evaluation times are fall equinox (September 23), spring equinox (March 21), summer solstice (June 21) and winter solstice (December 21). For mood symptoms, Hamilton Depression Rating Scale and Young Mania Rating Scale; for functioning Functioning Assessment Short Test; for neurocognition Stroop Test (ST) and Rey Auditory Verbal Learning Test (RAVLT), for biological rhythm Biological Rhythms Interview of Assessment in Neuropsychiatry, and Seasonal Pattern Assessment Questionnaire were used. Results: In terms of mood symptoms no seasonal variation was found. Across all four periods of assessment of BD group, statistically significant variation was only observed in the instant recall, learning and recognition domains of RAVLT and word test and color test domains of ST; however, it was not sufficient to distinguish the BD group separating from the control group. Conclusions: In terms of mood symptoms, psychosocial functionality, biological rhythm, neurocognition, no seasonal variation was demonstrated that could distinguish the BD group from the HC group. © 2020 by Turkish Association of Neuropsychiatry.Item Psychometric Properties of the Turkish Version of the Epilepsy Module of the KINDL Quality of Life Scale(Turkish Neuropsychiatric Society, 2022) Ergin D.; Demirbağ S.; Eser E.; Polat M.; Baydur H.Introduction: This study aims to present the psychometric properties of the Turkish version of the KINDLE quality of life scale, epilepsy module. Method: The psychometric properties of the KINDL Epilepsy module were evaluated from the aspect of internal consistency, reliability, and construct validity on an inpatient sample of 159 Turkish children (mean age 10.84±2.77 years) who had epilepsy. Results: The KINDL Epilepsy module (36 items) showed acceptable α coefficients ranging from 0.80 (social well-being) to 0.55 (treatment) for each domain. EFA suggested three sub-dimensions that we named as Physical, Mental and Social Well-being sub-dimensions. Root Mean Square Error of Approximation was found as 0.053, and Comparative Fit Index was 0.95. Good known groups results supported the construct validity of the instrument. Correlations between the income perception, family support and Duration of Epilepsy and the domains of its Epilepsy module were significantly high, indicating a satisfactory convergent validity. Conclusion: The Turkish version of the KINDL Epilepsy module showed module is a promising tool in this study. However, further research on the versions of the module in other languages is needed for its global use. © 2021 by Turkish Association of Neuropsychiatry.Item Anaplastic Ependymoma and Atypical Refractory Longitudinal Expansive Transverse Myelitis Due to Immune Reaction After COVID-19-A Case Discussion That Raises Many Unknown Questions About Covid-19; [ COVID-19 Sonrası İmmün Reaksiyona Bağlı Atipik Refrakter Longitudinal Ekspansif Transvers Miyelit ve Anaplastik Ependimom - COVID-19 Hakkında Birçok Bilinmeyen Soruyu Gündeme Getiren Bir Vaka Tartışması](Turkish Neuropsychiatric Society, 2024) İnalkaç Gemici Y.; Çelik F.; Göz Z.Z.; İşisağ A.; Yilmaz Ovali G.; Zileli M.; Barutçuoğlu M.; Mavioğlu H.Inflammatory neurologic manifestations, both infectious and non-infectious, have been reported secondary to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2/COVID-19). However, the relationship of spinal tumor and COVID-19 longitudinally extensive transverse myelitis (LETM) coexistence has never been reported in our knowledge. The clinical presentation and response to treatment of a 24-year-old female patient diagnosed with COVID-19 LETM and anaplastic ependymoma are described in this case report. The Patient’s cerebrospinal fluid COVID-19 antibody level was higher than serum and she was resistant to immunosuppressive treatment. The interaction between COVID-19 and spinal tumor was discussed in the light of the literature. It is thought that COVID-19 infection could trigger tumor growth in this patient. Also, this is the first case of anaplastic ependymoma and COVID-19 myelitis coexistence in the literature. © 2023 by Turkish Association of Neuropsychiatry.Item Adaptation into Turkish and Psychometric Properties of Athens Insomnia Scale; [Atina İnsomnia Ölçeğinin Türkçeye Uyarlanması ve Psikometrik Özellikleri](Turkish Neuropsychiatric Society, 2024) Elbi H.; Batum M.; Öztürk E.Ö.; Vatansever Balcan M.; Kisabay Ak A.; Yilmaz H.; Aydemir Ö.Introduction: The study aimed to adapt the “Athens Insomnia Scale” developed by Soldatos et al. into Turkish and to conduct validity and reliability analysis. Methods: This research was conducted on 215 patients with insomnia complaints and applied to Family Medicine, Neurology (Sleep Polyclinic), and Psychiatry outpatient clinics. Introductory Information Form, 8-item Athens Insomnia Scale, and Pittsburg Sleep Quality Index were administered to the participants. After the language adaptation of the scale, Cronbach’s alpha value was used as the consistency coefficient for reliability analysis. Exploratory factor analysis was examined for structural validity, and correlation coefficients between the Athens Insomnia Scale and its subscales and the Pittsburg Sleep Quality Index were examined for concurrent validity. Results: Cronbach’s alpha coefficient was calculated as 0.87. “Kaiser-Meyer-Olkin value was calculated for factor analysis.” In the Exploratory Factor Analysis, a two-factor structure with eigenvalues >1.0 and explaining 73.4% of the variance was obtained. According to the Exploratory Factor Analysis results for the Atina Insomnia Scale, the absolute value of the factor loadings of the eight items ranged between 0.650 and 0.865. The correlation coefficients between the total score and sub-dimensions of the Athens Insomnia Scale and the Pittsburg Sleep Quality Index-a scale assessing sleep quality were between 0.489–0.725 (p<0,01). For discriminant validity, Athens Insomnia Scale discriminated well between patients and healthy volunteers (Z=2.630, p=0,009). Conclusion: The Athens Insomnia Scale has been shown to have adequate reliability and validity in Turkish. © 2023 by Turkish Association of Neuropsychiatry-Available online at www.noropskiyatriarsivi.com.Item Effects of Oxytocin on Glutamate Mediated Neurotoxicity in Neuroblastoma Cell Culture(Turkish Neuropsychiatric Society, 2024) Gürbüz Özgür B.; Vural K.; Tuğlu M.İ.Introduction: We aimed to investigate the effects of oxytocin on neurite growth, cell viability, cell proliferation and apoptosis to demonstrate its neuroprotective effect on glutamate induced neurotoxicity in human neuroblastoma SH-SY5Y cell culture. Method: The effect of oxytocin on the toxic effects of glutamate in human neuroblastoma SH-SY5Y cell line with the Neurotoxicity Screening Test (NTT), apoptotic effects by Terminal Transferase dUTP Nick End Labeling (TUNEL) method and cell viability test by 3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide (MTT) method. In the NTT test; Neurotoxicity was induced by adding glutamate at a concentration of 32 µM to the cell culture. Oxytocin was added at 1, 3, 10, 30 and 100 µM concentrations and its effect on neurite elongation was investigated. It was demonstrated by TUNEL method that application of glutamate caused apoptosis. Afterwards, when glutamate and different doses of oxytocin were given, antiapoptotic effect was evaluated with the apoptotic index. Results: Glutamate was found to have a dose-dependent neurotoxic effect and reduced neurite elongation by 50% at a concentration of 32 μM. It was shown that the inhibition of neurite elongation caused by glutamate decreased in a dose-dependent manner by applying oxytocin. Especially oxytocin was found to significantly reduce neurite inhibition and show a neuroprotective effect starting from 10 µM concentrations. The concentration at which glutamate reduces cell proliferation by 50% was determined as 54 µM in MTT. Subsequently, it was observed that the adverse effect of glutamate on cell proliferation significantly decreased with oxytocin administration, depending on the dose. Conclusion: It was found that different concentrations of glutamate have a significant toxic effect on cell proliferation and viability, glutamate inhibits neurite elongation in a dose-dependent manner; oxytocin reduces neurite inhibition caused by glutamate, has a neuroprotective effect, increases cell viability and has antiapoptotic effects. © 2023 by Turkish Association of Neuropsychiatry.