Browsing by Publisher "Wiley-Blackwell"

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    European Vegetation Archive (EVA): An integrated database of European vegetation plots
    (Wiley-Blackwell, 2016) Chytrý M.; Hennekens S.M.; Jiménez-Alfaro B.; Knollová I.; Dengler J.; Jansen F.; Landucci F.; Schaminée J.H.J.; Aćić S.; Agrillo E.; Ambarli D.; Angelini P.; Apostolova I.; Attorre F.; Berg C.; Bergmeier E.; Biurrun I.; Botta-Dukát Z.; Brisse H.; Campos J.A.; Carlón L.; Čarni A.; Casella L.; Csiky J.; Ćušterevska R.; Dajić Stevanović Z.; Danihelka J.; De Bie E.; de Ruffray P.; De Sanctis M.; Dickoré W.B.; Dimopoulos P.; Dubyna D.; Dziuba T.; Ejrnæs R.; Ermakov N.; Ewald J.; Fanelli G.; Fernández-González F.; Fitzpatrick U.; Font X.; García-Mijangos I.; Gavilán R.G.; Golub V.; Guarino R.; Haveman R.; Indreica A.; Işik Gürsoy D.; Jandt U.; Janssen J.A.M.; Jiroušek M.; Kacki Z.; Kavgaci A.; Kleikamp M.; Kolomiychuk V.; Krstivojević Ćuk M.; Krstonošić D.; Kuzemko A.; Lenoir J.; Lysenko T.; Marcenò C.; Martynenko V.; Michalcová D.; Moeslund J.E.; Onyshchenko V.; Pedashenko H.; Pérez-Haase A.; Peterka T.; Prokhorov V.; Rašomavičius V.; Rodríguez-Rojo M.P.; Rodwell J.S.; Rogova T.; Ruprecht E.; Rusiņa S.; Seidler G.; Šibík J.; Šilc U.; Škvorc Z.; Sopotlieva D.; Stančić Z.; Svenning J.-C.; Swacha G.; Tsiripidis I.; Turtureanu P.D.; Uğurlu E.; Uogintas D.; Valachovič M.; Vashenyak Y.; Vassilev K.; Venanzoni R.; Virtanen R.; Weekes L.; Willner W.; Wohlgemuth T.; Yamalov S.
    The European Vegetation Archive (EVA) is a centralized database of European vegetation plots developed by the IAVS Working Group European Vegetation Survey. It has been in development since 2012 and first made available for use in research projects in 2014. It stores copies of national and regional vegetation- plot databases on a single software platform. Data storage in EVA does not affect on-going independent development of the contributing databases, which remain the property of the data contributors. EVA uses a prototype of the database management software TURBOVEG 3 developed for joint management of multiple databases that use different species lists. This is facilitated by the SynBioSys Taxon Database, a system of taxon names and concepts used in the individual European databases and their corresponding names on a unified list of European flora. TURBOVEG 3 also includes procedures for handling data requests, selections and provisions according to the approved EVA Data Property and Governance Rules. By 30 June 2015, 61 databases from all European regions have joined EVA, contributing in total 1 027 376 vegetation plots, 82% of them with geographic coordinates, from 57 countries. EVA provides a unique data source for large-scale analyses of European vegetation diversity both for fundamental research and nature conservation applications. Updated information on EVA is available online at http://euroveg.org/eva-database. © 2016 International Association for Vegetation Science.
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    How plot shape and spatial arrangement affect plant species richness counts: implications for sampling design and rarefaction analyses
    (Wiley-Blackwell, 2016) Güler B.; Jentsch A.; Apostolova I.; Bartha S.; Bloor J.M.G.; Campetella G.; Canullo R.; Házi J.; Kreyling J.; Pottier J.; Szabó G.; Terziyska T.; Uğurlu E.; Wellstein C.; Zimmermann Z.; Dengler J.
    Questions: How does the spatial configuration of sampling units influence recorded plant species richness values at small spatial scales? What are the consequences of these findings for sampling methodology and rarefaction analyses?. Location: Six semi-natural grasslands in Western Eurasia (France, Germany, Bulgaria, Hungary, Italy, Turkey). Methods: In each site we established six blocks of 40 cm × 280 cm, subdivided into 5 cm × 5 cm micro-quadrats, on which we recorded vascular plant species presence with the rooted (all sites) and shoot (four sites) presence method. Data of these micro-quadrats were then combined to achieve larger sampling units of 0.01, 0.04 and 0.16 m² grain size with six different spatial configurations (square, 4:1 rectangle, 16:1 rectangle, three variants of discontiguous randomly placed micro-quadrats). The effect of the spatial configurations on species richness was quantified as relative richness compared to the mean richness of the square of the same surface area. Results: Square sampling units had significantly lower species richness than other spatial configurations in all countries. For 4:1 and 16:1 rectangles, the increase of rooted richness was on average about 2% and 8%, respectively. In contrast, the average richness increase for discontiguous configurations was 7%, 17% and 40%. In general, increases were higher with shoot presence than with rooted presence. Overall, the patterns of richness increase were highly consistent across six countries, three grain sizes and two recording methods. Conclusions: Our findings suggest that the shape of sampling units has negligible effects on species richness values when the length–width ratio is up to 4:1, and the effects remain small even for more elongated contiguous configurations. In contrast, results from discontiguous sampling units are not directly comparable with those of contiguous sampling units, and are strongly confounded by spatial extent. This is particularly problematic for rarefaction studies where spatial extent is often not controlled for. We suggest that the concept of effective area is a useful tool to report effects of spatial configuration on richness values, and introduce species–extent relationships (SERs) to describe richness increases of different spatial configurations of sampling units. © 2016 International Association for Vegetation Science
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    Gingival crevicular fluid and salivary resistin and tumor necrosis factor-alpha levels in Obese children with gingivitis
    (Wiley-Blackwell, 2018) Doğusal G.; Afacan B.; Bozkurt E.; Sönmez I.
    Background: This study aimed to evaluate the levels of resistin and tumor necrosis factor-alpha (TNF-α) in gingival crevicular fluid (GCF) and saliva of obese children with gingivitis. Methods: One-hundred and thirty children (65 obese and 65 normal weight; age range 8 to 12 years) were recruited for the study. The children were classified into four subgroups based on their body mass and periodontal status; 1) obese children with gingivitis (OG, n = 33); 2) obese children with healthy periodontium (OH, n = 32); 3) normal weight children with gingivitis (NWG, n = 32); 4) normal weight children with healthy periodontium (NWH, n = 33). Body mass index (BMI) percentile, probing pocket depth (PPD), gingival index (GI), and plaque index (PI) were recorded. Resistin and TNF-α were analyzed in GCF and saliva samples by ELISA. Results: Obese children had higher BMI percentiles than normal weight children (p < 0.0001). PPD, GI, PI, GCF volume, GCF, and salivary resistin and TNF-α levels were similar between obese and normal weight children (P > 0.05). OG and NWG subgroups had significantly higher GI, PI, GCF volume, GCF resistin total amounts, and salivary resistin concentrations but lower GCF resistin and TNF-α concentrations than OH and NWH (P < 0.0001 for all). GCF resistin total amounts were positively correlated with GI, PI, and GCF TNF-α total amounts (P < 0.05). Conclusions: To our knowledge, this is the first study evaluated the levels of resistin in GCF and saliva of children. Obesity is not associated with GCF and salivary resistin and TNF-α levels in children in the presence of gingival inflammation. © 2018 American Academy of Periodontology.
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    The evaluation of peri-implant sulcus fluid osteocalcin, osteopontin, and osteonectin levels in peri-implant diseases
    (Wiley-Blackwell, 2018) Cakal O.T.; Efeoglu C.; Bozkurt E.
    Background: Peri-implant mucositis is an inflammation of the soft tissues surrounding an implant. Peri-implantitis refers to a process characterized by peri-implant bone loss along with an inflammation of the soft tissues. Osteocalcin, osteopontin, and osteonectin proteins are related to bone remodeling. The aim of the present study was to investigate peri-implant sulcus fluid (PISF) osteocalcin, osteopontin, and osteonectin levels in peri-implant mucositis and peri-implantitis. Methods: Fifty-two implants with peri-implantitis, 46 implants with peri-implant mucositis, and 47 control implants were included in the study. Clinical parameters including probing depth, modified sulcus bleeding index and modified plaque index were recorded. PISF osteocalcin, osteopontin, and osteonectin levels were analyzed by ELISA kits. Results: There were no significant differences in PISF osteocalcin, osteopontin, and osteonectin total amounts between healthy controls, peri-implant mucositis and periimplantitis groups (P > 0.05). Probing depths were not correlated with PISF osteocalcin, osteopontin, and osteonectin levels in the study groups (P > 0.05). Conclusions: Soft tissue inflammation around dental implants does not cause a change in osteocalcin, osteopontin, and osteonectin levels in PISF. Also, periimplantitis does not seem to give rise to an increase in PISF levels of osteocalcin, osteopontin, and osteonectin. © 2018 American Academy of Periodontology.
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    sPlot – A new tool for global vegetation analyses
    (Wiley-Blackwell, 2019) Bruelheide H.; Dengler J.; Jiménez-Alfaro B.; Purschke O.; Hennekens S.M.; Chytrý M.; Pillar V.D.; Jansen F.; Kattge J.; Sandel B.; Aubin I.; Biurrun I.; Field R.; Haider S.; Jandt U.; Lenoir J.; Peet R.K.; Peyre G.; Sabatini F.M.; Schmidt M.; Schrodt F.; Winter M.; Aćić S.; Agrillo E.; Alvarez M.; Ambarlı D.; Angelini P.; Apostolova I.; Arfin Khan M.A.S.; Arnst E.; Attorre F.; Baraloto C.; Beckmann M.; Berg C.; Bergeron Y.; Bergmeier E.; Bjorkman A.D.; Bondareva V.; Borchardt P.; Botta-Dukát Z.; Boyle B.; Breen A.; Brisse H.; Byun C.; Cabido M.R.; Casella L.; Cayuela L.; Černý T.; Chepinoga V.; Csiky J.; Curran M.; Ćušterevska R.; Dajić Stevanović Z.; De Bie E.; de Ruffray P.; De Sanctis M.; Dimopoulos P.; Dressler S.; Ejrnæs R.; El-Sheikh M.A.E.-R.M.; Enquist B.; Ewald J.; Fagúndez J.; Finckh M.; Font X.; Forey E.; Fotiadis G.; García-Mijangos I.; de Gasper A.L.; Golub V.; Gutierrez A.G.; Hatim M.Z.; He T.; Higuchi P.; Holubová D.; Hölzel N.; Homeier J.; Indreica A.; Işık Gürsoy D.; Jansen S.; Janssen J.; Jedrzejek B.; Jiroušek M.; Jürgens N.; Kącki Z.; Kavgacı A.; Kearsley E.; Kessler M.; Knollová I.; Kolomiychuk V.; Korolyuk A.; Kozhevnikova M.; Kozub Ł.; Krstonošić D.; Kühl H.; Kühn I.; Kuzemko A.; Küzmič F.; Landucci F.; Lee M.T.; Levesley A.; Li C.-F.; Liu H.; Lopez-Gonzalez G.; Lysenko T.; Macanović A.; Mahdavi P.; Manning P.; Marcenò C.; Martynenko V.; Mencuccini M.; Minden V.; Moeslund J.E.; Moretti M.; Müller J.V.; Munzinger J.; Niinemets Ü.; Nobis M.; Noroozi J.; Nowak A.; Onyshchenko V.; Overbeck G.E.; Ozinga W.A.; Pauchard A.; Pedashenko H.; Peñuelas J.; Pérez-Haase A.; Peterka T.; Petřík P.; Phillips O.L.; Prokhorov V.; Rašomavičius V.; Revermann R.; Rodwell J.; Ruprecht E.; Rūsiņa S.; Samimi C.; Schaminée J.H.J.; Schmiedel U.; Šibík J.; Šilc U.; Škvorc Ž.; Smyth A.; Sop T.; Sopotlieva D.; Sparrow B.; Stančić Z.; Svenning J.-C.; Swacha G.; Tang Z.; Tsiripidis I.; Turtureanu P.D.; Uğurlu E.; Uogintas D.; Valachovič M.; Vanselow K.A.; Vashenyak Y.; Vassilev K.; Vélez-Martin E.; Venanzoni R.; Vibrans A.C.; Violle C.; Virtanen R.; von Wehrden H.; Wagner V.; Walker D.A.; Wana D.; Weiher E.; Wesche K.; Whitfeld T.; Willner W.; Wiser S.; Wohlgemuth T.; Yamalov S.; Zizka G.; Zverev A.
    Aims: Vegetation-plot records provide information on the presence and cover or abundance of plants co-occurring in the same community. Vegetation-plot data are spread across research groups, environmental agencies and biodiversity research centers and, thus, are rarely accessible at continental or global scales. Here we present the sPlot database, which collates vegetation plots worldwide to allow for the exploration of global patterns in taxonomic, functional and phylogenetic diversity at the plant community level. Results: sPlot version 2.1 contains records from 1,121,244 vegetation plots, which comprise 23,586,216 records of plant species and their relative cover or abundance in plots collected worldwide between 1885 and 2015. We complemented the information for each plot by retrieving climate and soil conditions and the biogeographic context (e.g., biomes) from external sources, and by calculating community-weighted means and variances of traits using gap-filled data from the global plant trait database TRY. Moreover, we created a phylogenetic tree for 50,167 out of the 54,519 species identified in the plots. We present the first maps of global patterns of community richness and community-weighted means of key traits. Conclusions: The availability of vegetation plot data in sPlot offers new avenues for vegetation analysis at the global scale. © 2019 International Association for Vegetation Science
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    Gingival crevicular fluid and salivary HIF-1α, VEGF, and TNF-α levels in periodontal health and disease
    (Wiley-Blackwell, 2019) Afacan B.; Öztürk V.Ö.; Paşalı Ç.; Bozkurt E.; Köse T.; Emingil G.
    Background: Hypoxia-inducible factor-1 alpha (HIF-1α) is expressed as an adaptive response to hypoxia, mediates angiogenesis through the expression of vascular endothelial growth factor (VEGF) and can be induced by tumor necrosis factor-alpha (TNF-α). This study aimed to investigate the gingival crevicular fluid (GCF) and salivary HIF-1α, VEGF, and TNF-α levels in periodontal health and disease. Methods: A total of 87 individuals, 20 generalized aggressive periodontitis (G-AgP), 20 chronic periodontitis (CP), 26 gingivitis patients, and 21 periodontally healthy individuals, were included. Clinical periodontal parameters were recorded; GCF and salivary samples were collected; and HIF-1α, VEGF, and TNF-α levels were measured by enzyme-linked immunosorbent assay. Nonparametric tests were used for the statistical analyses. Results: G-AgP and CP groups had significantly higher GCF HIF-1α, VEGF, and TNF-α total amounts than gingivitis and healthy groups (P < 0.05). GCF HIF-1α and TNF-α total amounts in gingivitis group were significantly higher than the healthy group (P < 0.05). GCF and salivary concentrations of biomarkers were similar in both periodontitis groups (P > 0.05). Salivary HIF-1α concentrations in gingivitis group were significantly higher than G-AgP and healthy groups (P < 0.05). GCF HIF-1α, VEGF, and TNF-α total amounts were positively correlated with the site-specific clinical periodontal parameters and with each other (P < 0.05). Conclusions: HIF-1α is detectable in GCF and saliva of periodontally diseased and healthy individuals, and the GCF levels of the biomarker can be affected by disease status. Increased GCF HIF-1α, VEGF, and TNF-α levels in both chronic and aggressive form of periodontitis might suggest the role of TNF-α/HIF-1α/VEGF pathway in the pathogenesis of periodontal diseases. © 2018 American Academy of Periodontology
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    Impact resistance of deflection-hardening fiber reinforced concretes with different mixture parameters
    (Wiley-Blackwell, 2019) Banyhussan Q.S.; Yıldırım G.; Anıl Ö.; Erdem R.T.; Ashour A.; Şahmaran M.
    The impact behavior of deflection-hardening High Performance Fiber Reinforced Cementitious Concretes (HPFRCs) was evaluated herein. During the preparation of HPFRCs, fiber type and amount, fly ash to Portland cement ratio and aggregate to binder ratio were taken into consideration. HPFRC beams were tested for impact resistance using free-fall drop-weight test. Acceleration, displacement, and impact load versus time graphs were constructed and their relationship to the proposed mixture parameters were evaluated. The paper also aims to present and verify a nonlinear finite element analysis, employing the incremental nonlinear dynamic analysis, concrete damage plasticity model, and contact surface between the dropped hammer and test specimen available in ABAQUS. The proposed modeling provides extensive and accurate data on structural behavior, including acceleration, displacement profiles, and residual displacement results. Experimental results which are further confirmed by numerical studies show that impact resistance of HPFRC mixtures can be significantly improved by a proper mixture proportioning. In the presence of high amounts of coarse aggregates, fly ash, and increased volume of hybrid fibers, impact resistance of fiberless reference specimens can be modified in a way to exhibit relatively smaller displacement results after impact loading without risking the basic mechanical properties and deflection-hardening response with multiple cracking. © 2019 fib. International Federation for Structural Concrete
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    Effect of non-surgical periodontal treatment on gingival crevicular fluid hypoxia inducible factor-1 alpha, vascular endothelial growth factor and tumor necrosis factor-alpha levels in generalized aggressive periodontitis patients
    (Wiley-Blackwell, 2020) Afacan B.; Keleş Yücel Z.P.; Paşali Ç.; Atmaca İlhan H.; Köse T.; Emingil G.
    Background: Hypoxia-inducible angiogenic pathway involving hypoxia inducible factor-1 alpha (HIF-1α), vascular endothelial growth factor (VEGF) and tumor necrosis factor-alpha (TNF-α) may regulate several biological processes related to inflammation. The present study aimed to assess the effect of non-surgical periodontal treatment on gingival crevicular fluid (GCF) HIF-1α, VEGF, and TNF-α levels in generalized aggressive periodontitis (G-AgP). Methods: Twenty G-AgP patients and 20 periodontally healthy individuals were included. G-AgP patients received scaling and root planning (SRP), per quadrant at a 1-week-interval, performed with ultrasonic and periodontal hand instruments. GCF samples were collected and clinical periodontal parameters including probing depth, clinical attachment level, gingival index and plaque index were recorded at baseline, 1 and 3 months after treatment. Biomarker levels in GCF were analyzed by ELISA. Results: At baseline all clinical parameters and GCF HIF-1α, VEGF, and TNF-α levels were significantly higher in G-AgP patients compared to healthy control (P < 0.05). All clinical parameters improved over the 3-month-period in G-AgP patients (P < 0.05). GCF HIF-1α levels in G-AgP reduced at 1 and 3 months post-treatment, however, this did not reach to statistical significance (P > 0.05). GCF VEGF and TNF-α levels remained unchanged throughout the study period (P > 0.05). Conclusions: Within the limitations of the present study, although HIF-1α seems to possess a potential diagnostic value for G-AgP, it might not be a proper predictor of clinically favorable treatment outcome. SRP plus different adjunctive therapies could provide better information about the prognostic role of hypoxia-inducible angiogenic pathway in G-AgP. © 2020 The Authors. Journal of Periodontology published by Wiley Periodicals, Inc. on behalf of American Academy of Periodontology
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    Experimental and numerical investigation of impact behavior of reinforced concrete slab with different support conditions
    (Wiley-Blackwell, 2020) Yılmaz T.; Kıraç N.; Anıl Ö.; Erdem R.T.; Hoşkal V.
    Reinforced concrete (RC) slabs may be subjected to impulsive dynamic loads such as blast and impact during their service period. Many studies related to the impact behavior of RC slabs have been presented. However, comprehensive studies where the effect of the support conditions on the impact behavior of RC slabs has been investigated are still limited. Thus, this study has focused on the effects of the support types and the support layouts on the dynamic responses and the failure modes of RC slabs subjected to impact loads. In the first part of the study, 9 two-way RC slabs with various support layouts composed of fixed and hinged supports were tested under impact load via the drop-weight test setup. Two different input impact energies were transmitted to RC slabs during impact loading. The time histories of the accelerations and displacements occurred in RC slabs, and the impact loads acting on RC slabs were recorded. The crack patterns due to the impact load were observed. The dynamic responses obtained by experiments have been interpreted in detail. In the second part, a detailed finite element procedure in which explicit dynamic analysis is performed has been introduced for verification of the experimental results. Good agreement between the experimental and the numerical results has been demonstrated. It has been concluded that proposed finite element procedures can be used for evaluation of the dynamic responses and failure modes of RC slabs under low-velocity impact load. © 2020 fib. International Federation for Structural Concrete
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    Performance of engineered cementitious composites under drop-weight impact: Effect of different mixture parameters
    (Wiley-Blackwell, 2020) Yıldırım G.; Khiavi F.E.; Anıl Ö.; Şahin O.; Şahmaran M.; Erdem R.T.
    Current research focuses on the experimental and numerical determination of impact performance of engineered cementitious composites (ECC). Performance assessment of ECC beams with different mixture parameters was made. Mixtures were produced with different replacement rates of Class-F fly ash and slag with Portland cement, water to binder ratios and fiber types (polyvinyl alcohol [PVA] and nylon [N]). Experimental works were validated with incremental dynamic analyses performed by ABAQUS finite element software. Impact testing results were further supported by mechanical property results. Results reveal that each individual mixture parameter used is distinctively effective in modifying the properties under both sudden impact and slow static loading. In brief, enhanced impact resistance is noted when ECC is produced with slag, low amounts of pozzolanic materials, low W/B ratio, fiber addition and PVA fibers. Experimental results were also in line with the numerical results from ABAQUS largely. Significantly, cost-effective N fibers were also shown to be fully replaceable with costly PVA fibers without jeopardizing mechanical/impact performance, if mixture design parameters are adjusted suitably. Current research is likely to attract further research on the development of ECC that is with lower cost and comparable impact/mechanical performance with regards to widely studied more expensive counterparts in the literature. © 2019 fib. International Federation for Structural Concrete
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    Determination of Physicochemical Properties, Fatty Acid, Tocopherol, Sterol, and Phenolic Profiles of Expeller–Pressed Poppy Seed Oils from Turkey
    (Wiley-Blackwell, 2020) Aksoylu Özbek Z.; Günç Ergönül P.
    In this study, the aim was to characterize the physicochemical properties and some bioactive compounds of expeller-pressed oils of five registered poppy seed varieties (TMO–1, Ofis–8, Ofis–96, Ofis–95, Ofis–3) grown in Turkey. The amounts of total carotenoids, chlorophylls, phenols, and antioxidant activities of oils ranged between 0.08–0.24 mg 100 g−1, 0.03–9.04 mg pheophytin a kg−1, 3.41–8.57 mg gallic acid equivalent 100 g−1, and 5.60–7.33 mM Trolox equivalent 100 g−1, respectively. The most abundant fatty acid in poppy seed oils was linoleic acid (69.85–74.02%), followed by oleic acid (13.98–16.99%), and palmitic acid (8.51–9.75%). In addition, poppy seed oils were rich in β–sitosterol (133.47–153.42 mg 100 g−1), campesterol (45.36–58.60 mg 100 g−1), and δ–5–avenasterol (28.21–39.40 mg 100 g−1). High amounts of γ–tocopherol and α–tocopherol were detected. This research is the first study, which identified and quantified the polyphenol, β–carotene, and lutein compounds of expeller–pressed poppy seed oils by HPLC. Tyrosol, apigenin, syringic acid, 3–hydroxytyrosol, luteolin, p–coumaric acid, quercetin, ferulic acid, sinapic acid, and veratric acid were detected in expeller-pressed poppy seed oils. © 2020 AOCS
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    Full-mouth disinfection effects on gingival fluid calprotectin, osteocalcin, and N-telopeptide of Type I collagen in severe periodontitis
    (Wiley-Blackwell, 2020) Afacan B.; Çınarcık S.; Gürkan A.; Özdemir G.; İlhan H.A.; Vural C.; Köse T.; Emingil G.
    Background: To compare the effects of full-mouth disinfection (FMD) and full-mouth ultrasonic debridement (FMUD) on clinical, microbiological and biochemical parameters with conventional quadrant-wise scaling and root planning (Q-SRP) in severe chronic periodontitis. Methods: In the present prospective randomized controlled clinical trial with three parallel arms (#NCT04038801), 60 chronic periodontitis patients were randomly assigned to three study groups by a consecutive number in ascending order: FMD (n = 20), FMUD (n = 20), and Q-SRP (n = 20). All measurements and treatments were performed by the same investigator. At baseline, gingival crevicular fluid (GCF) and subgingival plaque were collected and clinical periodontal parameters were recorded. Ultrasonic debridement was completed within 24 hours in FMD and FMUD groups. Chlorhexidine gluconate was used for FMD. Q-SRP was performed by hand instruments per quadrant at 1-week-intervals. Clinical measurements and sampling were repeated at 1, 3, and 6 months after treatment. Real-time PCR was used for quantitative analysis of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia, Fusobacterium nucleatum, and total bacteria count. GCF Calprotectin, osteocalcin, and N-telopeptide of type I collagen (NTx) levels were analyzed by ELISA. The changes of GCF biomarker levels after treatment between groups were the primary outcomes. Results: No harm was observed. All treatment strategies resulted in significant improvements in all clinical parameters (P < 0.05), with no significant differences between study groups at all time-points (P ˃ 0.05). Aggregatibacter actinomycetemcomitans was significantly decreased in FMD compared to FMUD and Q-SRP at 6 months (P < 0.05). Although GCF NTx total amounts increased in all groups during the study period, this increase was less prominent in full-mouth groups at three time points after treatment (P < 0.05). Conclusions: Present results represent the short-term effects. Full-mouth treatment approaches offered limited beneficial effects on microbiological and biochemical parameters over quadrant-wise approach. All three treatment strategies can be recommended in the management of severe chronic periodontitis. © 2020 American Academy of Periodontology