Browsing by Publisher "Yuzuncu Yil Universitesi Tip Fakultesi"
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Item Can cancer detection rate increase when transrectal biopsies were taken from the laterally?(Yuzuncu Yil Universitesi Tip Fakultesi, 2014) Karakose A.; Yuksel M.B.; Pirincci N.; Gorgel S.N.; Atesci Y.Z.; Gumus B.Acording to general opinion when biopsy is taken from the prostate’s lateral peripheral zone. More cancer is seen. In our study, the incidence of cancer in the lateral peripheral zone biopsies was investigated. In our study, 93 patients were analyzed retrospectively transrectal prostate biopsy. 12 core biopsies were taken from each patient. Medial peripheral zone (MPZ) and lateral peripheral zone (LPZ) biopsies compared the detection of prostate cancer. The average age of the patients was 67.2±10.3. Total PSA value in patients was found as 13.7 ng/mL. Prostate cancer was detected at the rate of 22.5% (21 patients) in 93 patients. 3 patients (14.3%) had prostate cancer in MPZ and 8 patients (38%) had prostate cancer in LPZ. Prostate cancer was detected at MPZ and LPZ at the rate of 47.7% (10 patients) in patients. Prostate cancer was more commonly detected in LPZ (p<0.05). Prostate biopsies of the LPZ biopsies more commonly cancer is seen. We believe it will increase the capture rate for prostate cancer if a sufficient number of biopsies were taken from the LPZ. © 2014, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.Item The effect of antibiotherapy on high serum PSA levels(Yuzuncu Yil Universitesi Tip Fakultesi, 2015) Karakose A.; Yuksel M.B.; Pirincci N.; Gorgel S.N.; Atesci Y.Z.; Gumus B.This study investigated the effect of antibiotics in patients with PSA value high than 4 ng/mL on tPSA, fPSA and fPSA/tPSA ratio without missing cancer and avoiding unnecessary biopsies. A total of 96 patients were included into the study with detected high level than 4 ng/mL serum PSA. Patients were divided into 2 groups according to the high level of PSA value. Group 1 included 49 patients with PSA level between 4-10 ng/mL. Group 2 included 47 patients with PSA level higher than 10 ng/mL. Patients were treated with Ciprofloxacin (500mg b.i.d.) orally for 2 weeks. All patients' PSA levels were evaluated and analyzed before and after antibiotic treatment. Statistical analyses were performed with SPSS version 18. A p value <0.05 was considered as significant. The mean age was 61.6 ±5.7 (51-75) years in group 1 and 63.1 ±8.7 (55-74) years in group 2. Suspicious DRE findings were significantly high in group 2. The mean tPSA values were 6.82±0.42 and 5.93±0.36 before and after antibiotic treatment in group 1 respectively. There was no significant differences in tPSA value before and after antibiotic treatment in group 1. The mean tPSA values were 32.53±8.23 and 11.72±5.61 before and after antibiotic treatment in group 2 respectively. The mean tPSA value decreased significantly after antibiotic treatment in group 2. Prostate cancer was detected in 32 patients after TRUS guided prostate biopsy. Prostate cancer was identified in 13 patients in group 1 and 19 patients in group 2. Antibiotic treatment in patients with PSA levels higher than 10 ng/mL is effective on prostate biopsy decision and antibiotic treatment can prevent unnecessary prostate biopsies. © 2015 Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.Item Evaluation of cardiac autonomic functions in children with thalassemia trait, iron deficiency anemia and iron deficiency(Yuzuncu Yil Universitesi Tip Fakultesi, 2018) Cetin M.; Moumin N.; Karaboga B.; Coskun S.; Gulen H.Distruption of cardiac autonomic functions during diseases associated with anemia were reported in multiple studies previously. Objective in this study is to investigate heart rate variability (HRV) for evaluation of cardiac autonomic functions in children patients with Thalassemia trait (TT), iron deficiency anemia (IDA) and iron deficiency (ID) without anemia. Twenty-five patients with TT, 25 patients with IDA, 25 patients with ID, and 25 healthy controls were assessed with 24-hour ambulatory electrocardiography recordings. The following time-domain indices were calculated; standard deviation values of all normal sinus R-R intervals for 24 hours (SDNN), standard deviation levels of all mean normal sinus R-R interspaces over each 5-minute strip in the 24-hour enrollments (SDANN), the square root of the mean of the sum of squares of differences between adjacent RR intervals (RMSSD), percentage of difference between adjacent normal R -R intervals that are greater than 50 ms computed for the overall 24-hour ECG recording (pNN50). Re-evaluation regarding HRV were done in children with IDA after 4 months of treatment. Although reduction in HRV parameters was detected in IDA group compared to ID, TT, and control groups, it wa s statistically not significant. The pNN50 was significantly low only in the IDA group (p=0.042). When ID group and TT group were compared with control group, it was found that HRV parameters were not affected. In IDA group, SDNN, SDANN, RMSSD and pNN50 index were significantly higher after trea tment (p=0.002, p=0.005, p=0.005, p=0.010, respectively). Our results indicate that cardiac autonomic activity are affected in IDA and improvement occurs after treatment. HRV parameters were found to be especially associated with hemoglobin and hematocrit values. © 2018, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.Item Evaluation and comparison of patients poisoned with acetaminophen and nonsteroidal anti-inflammatory drugs(Yuzuncu Yil Universitesi Tip Fakultesi, 2019) Çelik A.; Şaşmaz M.İ.We aimed to determine and compare the clinical and demographical features, treatments, follow-up, poisoning scores and outcome of cases with the acetaminophen and NSAIDs intoxication. Data of the patients who were at the age of 18 and older and applied to the Emergency Department with the acetaminophen or NSAIDs intoxication were retrospectively examined. The cases were divided into 2 groups as the acetaminophen and NSAIDs group. The cases‟ age, gender, drug dose, hospitalization status and periods, poisoning scores (PSS, APACHE-II) and last conditions in discharging from the hospital were compared. The döşe was taken by 99 (55%) patients in the acetaminophen group was calculated as toxic, and intravenous acetylcysteine was administered to 70 (38.9%) patients as an antidote. When the APACHE-II scores of the patients hospitalized in the intensive care unit were examined, the mean APACHE-II score of 54 patients in the acetaminophen group was 3.15±3.70, the mean APACHE-II score of 34 patients in the NSAIDs group was 4.15±3.13 and it was statistically higher (p=0.031). All the patients followed-up in both groups were discharged with healing except only 1 (0.6%) patient who developed acute liver failure. Conclusion: The mean APACHE-II score was low in both groups. Therefore, following-up the patients in a unit such as a toxicology unit instead of the intensive care unit can be beneficial in terms of both reducing the place and labor force loads and cost. Moreover, the acetylcysteine treatments in the early period of the acetaminophen toxicity are very effective in decreasing the mortality and morbidity. © 2019, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.Item The relationship between placental elasticity and prenatal serum screening markers and Doppler indices(Yuzuncu Yil Universitesi Tip Fakultesi, 2020) Akbaş M.; Koyuncu F.M.; Erenel H.; Ulkumen B.A.; Mete T.O.It has been shown that placental elasticity values were higher in pregnant women with preeclampsia and intrauterine growth restriction. The studies have been reported that prenatal serum screening markers and uterine artery Doppler parameters could be useful in the prediction of preeclampsia and intrauterine growth restriction. In this study, we aimed to investigate the relationship between placental elasticity values and these serum markers and Doppler indices in the first and second-trimester. 108 cases between 11-14 gestational weeks were enrolled for this study. Placental elasticity measurements were performed after the first-trimester combined test and Doppler assessment. The same procedures were repeated with the second-trimester triple test for 71 pregnant women who were followed-up. Correlation analysis of demographic characteristics, biochemical parameters and Doppler findings with placental elasticity values were performed. In the first-trimester, we found a statistically significant and positive correlation between placental elasticity values and bilateral uterine artery notching (r =0.193, p =0.045) and mean arterial pressure (r =0.398, p <0.001). Likewise, positive correlation was found between placental elasticity values and bilateral uterine artery notching (r =0.303, p =0.023) and mean arterial pressure (r =0.274, p =0.041) in the second-trimester. Our study showed that placental elasticity values were positively correlated with mean arterial pressure and bilateral uterine artery notching in the first and second-trimesters. In light of these findings, the utility of placental elasticity measurement in early gestation to predict pathologies due to insufficient placentation has to be proven with comprehensive studies. © 2020, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.Item Investigation of knowledge levels of neonatal screening programs in medical faculty staff(Yuzuncu Yil Universitesi Tip Fakultesi, 2020) Ay F.; Elbi H.; Özcan F.Newborn screening tests are an important preventive public health program that provides early detection of the treatable dise ases of infants. This study was carried out to investigate the knowledge levels of health workers and administrative staff on neonatal screening programs. Our research is a descriptive study. The sample wasn’t selected, and a questionnaire was conducted to 365 people in a period of about 2 months. The questionnaire used in the research consists of 20 questions prepared by searching the literature to measure the information of participants about neonatal screening programs. 89.04% and 10.95% of the employees participating in our study are health staff and administrative sta ff, respectively. 69% of the participants were female, and the average age was 33,13. 66% of the participants in the study had service years of 10 years o r less while 44% had service years of 11 years and longer. The largest group of the participants in the study is research assistants (28.4%) and the second largest group is nurses (22.1%). The total of General Administrative services, technical services and auxiliary servic es is 10,94%. It was seen that 98.4% of the participants were aware of the newborn screening tests. It can be concluded that both physicians and assistant health staff have high knowledge about subjects and applications related to newborn screening tests. However, it is noteworthy that some non-health staff members have inaccurate knowledge and thoughts about some applications related to newborn screening tests. © 2020, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.Item Evaluation of Apoptotic and Autophagic Effects of Thioridazine in Monolayer and Spheroid Cell Cultures(Yuzuncu Yil Universitesi Tip Fakultesi, 2023) Ersöz E.; Yapar R.; Çelik B.; Korkmaz M.Glioblastoma (GBM) is the most frequently seen brain tumor in adults. It is clear that new therapeutic agents are needed in this area. Spheroid cell cultures have advantages on imitating in vivo environment. Therefore, we investigated apoptotic and autophagic effects of Thioridazine (THZ) which is a potential anti-cancer agent on GBM cell lines, T98G and U-87 MG, comparatively in monolayer and spheroid cell cultures. The cytotoxic effect of THZ on cells was evaluated by MTT method. Besides, apoptotic and autophagic effects of THZ were determined by Annexin V and LC-3 antibody based methods. Validation performed also by assessment of apoptosis and autophagy with specific inhibitors. The analysis has revealed that IC50 values at 24 h were 12,67 μM (T98G) and 12.80 μM (U-87 MG) in monolayer cell culture, 29.30 μM (T98G) and 28.68 μM (U-87 MG) in spheroid cell culture. While apoptotic cell rate was determined at 24 h approximate 15% in both cell lines and cell cultures, autophagy induction rate was increased by 6.5-(T98G) and 5.6-(U-87 MG) fold in monolayer cell culture and by 3.3-(T98G) and 4.5-(U-87 MG) fold in spheroid cell culture. In our study THZ stimulates mostly autophagy rather than apoptosis. In addition, it can be suggested that in vitro cytotoxicity studies should perform with not only monolayer cell cultures but also with spheroid cell cultures for obtaining in vivo-like data. When all the evaluations are considered, THZ might be thought as a potential chemotherapeutic agent in the treatment of GBM. © 2023, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.Item The Importance of Radiological Imaging In The Medicolegal Evaluation of Gunshot Wounds: A Case Report(Yuzuncu Yil Universitesi Tip Fakultesi, 2023) Yavuz M.S.; Zeybek V.; Karabağ G.; Akın A.; Erbaş İ.Determining the shooting direction in gunshot wounds is very important, especially in cases where the number of suspects is more than one. In cases of gunshot wounds, a detailed anamnesis should be taken and an examination should be performed, it should be investigated whether the injury caused a bone fracture, and the diagnosis should be confirmed by radiological examinations. With the use of radiological examinations, the direction of the shot can be determined by evaluating the appearance of the metal fragments separated from the bullet core, which crashes into the bone tissue and bone fragments. Radiological imaging of a 32-year-old male patient who was injured in the left leg area with a firearm and was sent to Forensic Medicine Department of Medical School of Manisa Celal Bayar University to determine the shooting direction was evaluated. The case, whose entrance-exit holes were distinguished and the direction of the shot was determined by radiological imaging, is presented to guide the medicolegal evaluation. © 2023, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.Item Prognostic Value of Serum Neuron Specific Enolase and Pentraxin-3 In Acute Pulmonary Embolism(Yuzuncu Yil Universitesi Tip Fakultesi, 2023) Şaşmaz M.İ.; Tulay C.M.; Gurmen E.S.; Angin A.; Ulman C.The aim of this study is to investigate whether serum neuron-specific enolase (NSE) and pentraxin-3 (PTX-3) values are effective in the diagnosis and prognosis of acute pulmonary embolism. In addition, in the light of significant results, we aimed to determine a cut-off value for NSE and PTX-3 in acute pulmonary embolism and to try to determine the sensitivity-specificity in the diagnosis of pulmonary embolism according to these values. In this prospective study, patients who applied to the Emergency Department of Manisa Celal Bayar University School of Medicine between September 2019 and January 2021 and were diagnosed with acute pulmonary embolism constituted the study group and healthy volunteers without any chronic disease or drug use constituted the control group. Serum NSE and PTX-3 values of the patient and control groups were compared. In addition, demographic data, vital signs, laboratory findings, PESI (pulmonary embolism severity index) scores and prognoses of the patients were investigated. In this study 70 patients diagnosed with pulmonary embolism were included to the patient group. 36 (51.4%) of them were women and the mean age was 67.01 ± 14. 74 healthy volunteers were included to the control group; 45 of them (60.8%) were women and the mean age was 44.99 ± 12.85. In patient group the mean PTX-3 value of the was 1.753±1.91 ng/ml, the mean NSE value was 182.13±14.99 ng/ml. In control group, the mean PTX-3 value was 0.429±0.035 ng/ml, the mean NSE value was 166.51±5.14 ng/ml. While there was a statistical difference between two groups in terms of pentraxin-3 value, there was no difference in terms of NSE value. When the cut-off value of 1.115 ng/ml for serum pentraxin-3 in the ROC analysis in order to distunguish the patients with pulmonary embolism from the control group, sensitivity was found to be 58.6% and specificity to be 96%. In our study, we found that serum PTX-3 level is a powerful biomarker with high specificity in the diagnosis of acute pulmonary embolism and is positively associated with the severity and prognosis of the disease. Therefore, we believe that serum PTX-3 may be a guiding biomarker in the diagnosis and prognosis of acute pulmonary embolism in clinical practice. © 2023, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.Item Evaluation of Vertebral Fractures and Associated Injuries in Multiple Trauma Patients(Yuzuncu Yil Universitesi Tip Fakultesi, 2024) Cigerci Ç.; Şaşmaz M.İ.; Cigerci N.E.In this study, it was aimed to determine the accompanying organ injuries and their frequencies in trauma patients diagnosed with vertebral fracture in the emergency department. In this study, trauma patients aged 18 years and older and with at least one vertebral corpus fracture who applied to the Emergency Department of Hafsa Sultan Hospital of Manisa Celal Bayar University Faculty of Medicine between Januar y 2016 and December 2020 were retrospectively analyzed. In addition to vertebral fractures, the mechanism of trauma, accompanying organ injuries, the intervention and the prognosis of the patients were examined. Of the patients, %72 were male and the mean age was 46,07. The two most common trauma mechanisms causing vertebral fracture were falling from height and traffic accident. The vertebral region most affected by trauma was the thoracolumbar (28.7%) region. Compression fracture was detected in 52% of the patients, and burst fracture was detected in 19,3% of the patients. Neurological deficit was observed in 8% of the patients, and death in 3,4%. Thoracic injuries were detected in 41.3% of the patients, and extremity injuries in 26%, and these were the mo st common injuries accompanying vertebral fractures. In our study, concomitant cranial and maxillofacial injuries in cervical vertebral fractures and concomitant thoracic injuries in thoracic vertebral fractures were found to be significantly higher. Traffic accidents and falling from a height were determined as the two most common causes of vertebral fracture and were thought to be preventable causes. In addition, although distant traumas accompanied the affected vertebral region in vertebral fractures, it was observed that traumas of nearby structures were more common in general. © 2024, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.