Browsing by Subject "AGGRESSIVE PERIODONTITIS"

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    Gingival crevicular fluid interleukin-36β (-1F8), interleukin-36γ (-1F9) and interleukin-33 (-1F11) levels in different periodontal disease
    (PERGAMON-ELSEVIER SCIENCE LTD) Kursunlu, SF; Öztürk, VÖ; Han, B; Atmaca, H; Emingil, G
    Background: Periodontal inflammation is driven by the coordinated action of a number of factors, including the IL-1 family. Our study aimed to examine the levels of interleuldn (IL)-36 beta, IL-36 gamma and IL-33 levels in gingival crevicular fluid (GCF) from patients with different periodontal diseases. Materials and methods: A total of 80 subjects, 20 patients with generalized aggressive periodontitis (G-AgP), 20 patients with chronic periodontitis (CP), 20 with gingivitis and 20 periodontally healthy subjects were included. Periodontal status was evaluated by measuring probing depth, clinical attachment loss, papillary bleeding index and plaque index. GCF cytokine levels were analysed by ELISA. Results: CP, gingivitis and healthy groups had similar GCF IL-36 beta total amount (p > 0.008). G-AgP group had elevated IL-36 beta total amount compared to CP group (p < 0.008). G-AgP group had similar GCF IL-36 beta total amount to gingivitis and healthy groups (p > 0.008). GCF IL-36 gamma and IL-33 total amounts of the study groups were similar (p > 0.05). Conclusions: The present study demonstrated for the first time the presence of IL-36 beta, IL-36 gamma and IL-33 GCF levels with different periodontal diseases. High levels of IL-36-beta in the AgP group in comparison to CP group might suggest that periodontitis in the aggressive form could be related to the increase in GCF IL-36 beta. (C) 2014 Elsevier Ltd. All rights reserved.
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    Gingival Crevicular Fluid and Plasma Acute-Phase Cytokine Levels in Different Periodontal Diseases
    (WILEY) Becerik, S; Öztürk, VÖ; Atmaca, H; Atilla, G; Emingil, G
    Background: The aim of the present study is to investigate gingival crevicular fluid (GCF) and plasma acute-phase cytokines, interleukin-I beta (IL-1 beta), interleukin-6 (IL-6), interleukin-11 (IL-11), oncostatin M (OSM), and leukemia inhibitory factor (LIF) levels in patients with different periodontal diseases. Methods: Eighty individuals were included in this study; 20 with chronic periodontitis (CP), 20 with generalized aggressive periodontitis (GAgP), 20 with gingivitis, and 20 classified as healthy (H). Probing depth, clinical attachment level, plaque index, and papilla bleeding index were recorded. Plasma and GCF IL-1 beta, IL-6, IL-11, OSM, and LIF levels were analyzed by enzyme-linked immunosorbent assay. Results: CP and GAgP groups had significantly higher GCF IL-1 beta, IL-6, and IL-11 levels when compared with the H group (P <0.05). Conversely, GCF LIF levels of the CP and GAgP groups were lower than those of the H group (P<0.05). GCF OSM levels did not differ significantly among study groups. Plasma levels of all the cytokines studied were not significantly different among the study groups. Conclusions: Based on the present data, elevated IL-1 beta, IL-6, and IL-11 GCF levels, but not plasma levels, are suggested as reliable inflammatory biomarkers in periodontal diseases. Decreased LIF levels in diseased groups might reflect the possible beneficial effects of LIF in the modulation of inflammatory response in gingiva. J Periodontol 2012;83: 1304-1313.