Browsing by Subject "ANTIBIOTIC PRODUCTION"

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    ENHANCEMENT OF SOLID STATE FERMENTATION FOR PRODUCTION OF PENICILLIN G ON SUGAR BEET PULP
    (NORTH CAROLINA STATE UNIV DEPT WOOD & PAPER SCI) Taskin, E; Eltem, R; Soyak, E
    In this study, two local strains of Penicillium chrysogenum named EGEK458 and EGEK469 were selected for enhancement of Penicillin G (PenG) production under solid state fermentation (SSF) conditions. These two strains were selected among seven strains according to their fermentation yields for PenG production during previous tests under submerged fermentation conditions. Sugar beet pulp, an agro-industrial residue of the sugar industry, was used as an inert support for the first time in PenG production under SSF. In order to enhance the production of PenG, two points of moisture level and three concentration values of nutrients (impregnated in solid support), which are the key parameters in production of PenG, were compared. As the yields from solid and submerged fermentation were compared, 570U/g of PenG - almost 15 times higher quantities of its production vs. submerged conditions - were obtained under SSF conditions in 50 hours by the strain EGEK458. The conditions for the enhanced production of PenG were 65% moisture content with a four-fold concentrated nutrients impregnated solid support.
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    Antibacterial activity of volatile component and various extracts of Spirulina platensis
    (JOHN WILEY & SONS LTD) Ozdemir, G; Karabay, NU; Dalay, MC; Pazarbasi, B
    The methanol, dichloromethane, petroleum ether, ethyl acetate extracts and volatile components of Spirulina platensis were tested in vitro for their antimicrobial activity (four Gram-positive, six Gram-negative bacteria and Candida albicans ATCC 10239). GC-MS analysis of the volatile components of S. platensis resulted in the identification of 15 compounds which constituted 96.45% of the total compounds. The volatile components of S. platensis consisted of heptadecane (39.70%) and tetradecane (34.61%) as major components. The methanol extract showed more potent antimicrobial activity than dichloromethane, petroleum ether, ethyl acetate extracts and volatile components. Copyright (C) 2004 John Wiley Sons, Ltd.