Browsing by Subject "ARTERY DISEASE"

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    The Effects of an 8-week Walking Program on Serum Lipids, Circulation Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 in Post-menopausal Women
    (WALTER DE GRUYTER GMBH) Büyükyazi, G; Ulman, C; Taneli, F; Aksoy, D; Tikiz, H; Ari, Z
    Purpose: To examine the effects of an 8-week walking program on serum lipids, circulation matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in post-menopausal women. Method: Body weight, percent body fat, body mass index, estimated maximal oxygen consumption, blood lipids, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 concentrations were assessed and their matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1 molar ratios were calculated in exercise (n=12) and control (n=12) groups. Exercise group completed an eight-week walking program at moderate (similar to 6.29 +/- 0.15km/h; similar to 62% maximum heart rate reserve) intensity. Results: Significant changes in estimated maximal oxygen consumption, systolic and diastolic blood pressures, body weight, and body mass index (p<.05) were determined in exercise group. However, there were no significant changes in the measured blood lipids (triglyceride, cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol), matrix metalloproteinase-9, and tissue inhibitor of metalloproteinase-1 concentrations, and matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1 molar ratio of exercise group, except for a nearly significant change in tissue inhibitor of metalloproteinase-1 level (p=.092). We determined no significant changes in any of the measured parameters in control group. Conclusion: Despite its protective effects against coronary heart disease risks, the duration and intensity of this program is not sufficient to cause significant changes in blood lipids, matrix metalloproteinase-9, and tissue inhibitor of metalloproteinase-1 concentrations. A higher-intensity, longer-duration program accompanied with diet is proposed.
  • No Thumbnail Available
    Item
    Left ventricular aneurysm formation after anterior myocardial infarction
    (ELSEVIER SCI IRELAND LTD) Tikiz, H; Atak, R; Balbay, Y; Genç, Y; Kütük, E
    Background: Previous studies have reported controversial results regarding the clinical and angiographic factors involved in the left ventricular aneurysm (LVA) formation after myocardial infarction (MI). Objective: This study was performed to determine the clinical and angiographic factors that are priori predictors of LVA following anterior myocardial infarction and so to provide a paradigm which may identify patients who were candidates for aneurysm formation. Methods: Of the patients who underwent coronary angiography during the interval between 1995 and 2000 in our clinic, 809 were found to have anterior MI and LVA (aneurysm group) (677 men, 132 women, mean age 53.3 +/- 11.4 years). The clinical and the angiographic data of these patients were compared with those of 446 patients (399 men, 47 women, mean age 55.2 +/- 10.5 years) with previous anterior MI and without LVA (control group). Results: LVA was found to occur more frequently in females (16.3% in women and 10.4%, in men, P = 0.03) and in patients without previous angina (23.5 vs. 8.2%. P < 0.0001). Major cardiovascular risk factors, previous anti-anginal medication and thrombolytic therapy did not show a significant difference between the two groups. Angiographic examination revealed that single-vessel disease, proximal left anterior descending artery (LAD) stenosis, total LAD occlusion, mean stenosis in LAD artery, end-diastolic pressure and left ventricular score were all higher in the aneurysm group compared to control group. After adjustment for other clinical and angiographic variables, single-vessel disease [odds ratio (OR) 5.89, 95% confidence interval (CI) = 3.68-9.28, P < 0.0001), absence of previous angina (OR) = 4.21. 95% CI = 2.1-7.48, P = 0.0003), total LAD occlusion (OR = 2.63, 95% CI = 1.97-3.53, P < 0.0017) and female gender (OR = 1.60, 95% CI = 1.20-2.28, P = 0.043) remained the independent determinants of LVA formation after anterior MI. Conclusion: In patients with LVA, logistic regression analysis revealed that (1) single-vessel disease, (2) absence of previous angina, (3) total LAD occlusion and (4) female gender were independent determinants in the formation of LVA after anterior MI. Coronary collateral status and risk factors, such as hypertension, diabetes mellitus, hypercholesterolemia, smoking and family history of CAD were not found to be important determinants in the aneurysm formation. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.