Browsing by Subject "Anticancer activities"

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    Boswellia sacra essential oil manages colon cancer stem cells proliferation and apoptosis: a new perspective for cure
    (Bellwether Publishing, Ltd., 2021) Becer E.; Kabadayı H.; Başer K.H.C.; Vatansever H.S.
    Boswellia sacra Flueck essential oil is obtained from frankincense obtained from Boswellia sacra trees. The aim of this study was to investigate the in vitro anti-cancer activity of Boswellia sacra (BS) essential oil in CD133+ and CD133- Colo-320 cells. Essential oil was analyzed by GC-MS. CD133+ cells, cancer stem cells, were obtained from the Colo-320 by the MiniMACS system. Cytotoxicity were evaluated with MTT assay. Anti-cancer activity of BS essential oil was investigated by immunocytochemistry. 41 compounds were identified in the essential oil. 1:2 dilution BS essential oil was found to be active against all the cells for 24 h incubation. β-catenin immunoreactivity was significantly decreased in both BS essential oil-treated CD133+ and CD133- Colo-320 cells. Caspase-3 immunoreactivity significantly increased in BS essential oil-treated CD133- Colo-320 cells. We conclude that BS essential oil decreased β-catenin signaling molecules which play a crucial role in cancer cell proliferation. BS essential oil promoted apoptosis in CD133- Colo-320 cells. © 2020 Informa UK Limited, trading as Taylor & Francis Group.
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    Green synthesis of titanium nanoparticles using a sustainable microalgal metabolite solution for potential biotechnological activities
    (John Wiley and Sons Ltd, 2023) Mutaf T.; Caliskan G.; Ozel H.; Akagac G.; Öncel S.Ş.; Elibol M.
    In this study, green synthesis of titanium nanoparticles using liquids metabolites of microalgae, Porphyridium cruentum, was performed to evaluate potential biotechnological activity. The rising rates of multidrug-resistant bacteria and the number of cancer patients are driving the search for novel antimicrobial and anticancer agents to combat this threat. In recent years, with the increasing number of studies, nanomaterials are starting to be better understood and are emerging as a solution to this problem. Especially, green synthesized nanoparticles with anticancer, antioxidant, and antimicrobial activities have potential in biomedical applications because of their eco-friendly and biocompatible nature. Scanning electron microscopy (SEM) images revealed that spherical shaped Ti-NPs' size ranged from 62 to 133 nm. This study aimed to assess the effectiveness of antibacterial activity of Ti-NPs and chitosan-coated Ti-NPs against Escherichia coli and Staphylococcus aureus using disc diffusion assay. It demonstrated the concentration-dependent cytotoxic effect of Ti-NPs of human prostate adenocarcinoma (PC-3), human alveolar adenocarcinoma (A549), and human mammary gland adenocarcinoma (MDA-MB) cancer cell lines. This present study shows promising outcomes for possible future applications of synthesized Ti-NPs as a novel antibacterial and cytotoxic agent for biomedical applications such as drug delivery, biosensor, and hyperthermia. © 2023 Curtin University and John Wiley & Sons, Ltd.