Browsing by Subject "BENZIMIDAZOLIUM IODIDE SALTS"

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    ANTIMICROBIAL AND SOD-LIKE ACTIVITIES OF N,N'-BIS(FERROCENYLMETHYLENE)ETHYLENEDIAMINE SCHIFF BASE AND IT'S METAL COMPLEXES
    (SOC CHILENA QUIMICA) Özbek, HA; Çinar, S; Oskay, M; Aydemir, T; Demirhan, F
    The synthesized N,N'-bis(ferrocenylmethylene)ethylenediamine Schiff base and it's metal complexes were screened in vitro for antimicrobial activity against two Gram-positive (Staphylococcus aureus ATCC 25923, Bacillus cereus ATCC 7064), four Gram-negative (Escherichia coli ATCC 25922, Citrobacter koseri DBCC 01, Entorebacter aeruginosa ATCC 13048, Salmonella typhimurium DBCC 02) and antifungal activity against a Candida albicans. MIC values of the compounds ranged from 27 to 533 mu g/mL. Compound (5) showed very strong activity against S. aureus with the best MIC (27 mu g/mL). The lowest MIC for C. albicans was obtained 107 mu g/mL. The superoxide dismutase activity of Schiff base and it's metal complexes has been measured and discussed. SOD-like activities of bis ferrocenyl Schiff base ligand metal complexes were investigated using NBT. While only the Cu (II) complex showed SOD-like (40 mu m IC50) activity, the SOD-like activity value was not determined in the other complex and ligand.
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    Synthesis, structure, electrochemical and antimicrobial properties of N,N′-bis(ferrocenylmethyl)imidazolinium salts
    (ELSEVIER SCIENCE SA) Özbek, HA; Aktas, PS; Daran, JC; Oskay, M; Demirhan, F; Çetinkaya, B
    The N, N'-bis(ferrocenylmethyl)imidazolinium chloride (3) and bromide (4) were prepared by reaction of N,N'-bis(ferrocenylmethyl)ethylenediamine (2) with NH4X (X = Cl, Br). The N,N'-bis(ferrocenylmethyl)imidazolinium tetrafluoroborate (6) was obtained in two steps from compound (2). The first step involves the synthesis of N,N'-bis(ferrocenylmethyl)imidazolidine (5) by condensation of (2) with aqueous formaldehyde. Compound (5) was successfully converted to the N,N'-bis(ferrocenylmethyl)imidazolinium tetrafluoroborate (6) by treatment with tritylium tetrafluoroborate. The new compounds were characterized by H-1 and C-13 NMR, IR and elemental analysis techniques which support the proposed structures. The X-ray crystal structure of the N,N'-bis(ferrocenylmethyl)imidazolidine (5) shows two ferrocenyl moieties bridged by an imidazolidine ring. The electrochemical properties were determined by cyclic voltammetry for all compounds. The compounds were screened for their in vitro antimicrobial activities against the Gram-positive, Gram-negative bacteria and antifungal activity against a Candida albicans. (3), (4), (6) show significant antimicrobial activity and theirs MIC values ranged from 169 to 520 mu g/mL. (C) 2014 Elsevier B.V. All rights reserved.