Browsing by Subject "BIPOLAR DISORDER"

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    Reliability and validity of Turkish version of DSM-5 Level 2 Depression Adult Scale
    (CUMHURIYET UNIV TIP FAK PSIKIYATRI ANABILIM DALI) Aydin Asik, E; Çöldür, EÖ; Aydemir, Ö
    Objective: This study aims to demonstrate the reliability and validity of Turkish version of DSM-5 Level 2 Depres-sion Adult Scale which was developed to measure the severity of depression. Methods: The study group included 51 in or out-patients who met the criteria for major depressive disorder according to DSM-5. Sixty-five volunteers without any mental or physical disease were also recruited as a control group. Beck Depression Inventory (BDI), which is the most widely used self-report scale, was used for concurrent validity. Internal consistency coefficient and item-total correlation analysis were performed for reliability. Exploratory factor analysis was used for validity, as BDI was used for concurrent validity. Results: Mean age was 40.5 +/- 11.4 in the patient group and 21.8 +/- 4.9 years in the control group, respectively. 62.1% of the sample group (n=72) were female. 59.5% of the group were college graduates, 16.4% were primary school graduates and 14.7% were high school graduates. Disease duration for major depressive disorder was 13.5 +/- 10.5 years for the patient group. The internal consistency of the Level 2 Depression Adult was 0.96. Item-total correlation coefficients were between 0.71 and 0.90. For the exploratory factor analysis of sample adequacy of DSM-5 Level 2 Depression Adult Scale, Kaiser-Meger-Olkin (KMO) coefficient and Bartlett coefficient was calculated as 0.91 and 1026.62, respectively. Single-factor solution was obtained with an eigen value of 6.27, representing 78.3% of the variance. Factor loadings of the items were between 0.77 and 0.92. Correlation coefficient of Level 2 Depression Adult Scale with BDI was found as r=0.76. Conclusion: The Turkish version of DSM-5 Level 2 Depression Adult Scale is reliable and valid.
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    Oxidative stress in schizophrenia: a case-control study on the effects on social cognition and neurocognition
    (BMC) Gonzalez-Liencres, C; Tas, C; Brown, EC; Erdin, S; Onur, E; Cubukcoglu, Z; Aydemir, O; Esen-Danaci, A; Brüne, M
    Background: Schizophrenia is a debilitating mental disorder that presents impairments in neurocognition and social cognition. Several studies have suggested that the etiology of schizophrenia can be partly explained by oxidative stress. However, our knowledge about the implications of oxidative stress on illness-related cognitive deficits is still far from being clear. The aim of this work was to study the role of oxidative stress molecules on social cognition and neurocognition in patients with schizophrenia. Methods: We assessed the peripheral levels of several molecules associated with oxidative stress, namely nitric oxide (NO), malondialdehyde (MDA), glutathione (GSH), homocysteine, superoxide dismutase (SOD) and neurotrophin 4/5 (NT4/5), in forty-one patients with schizophrenia and forty-three healthy participants. A battery of tests to measure neurocognition and social cognition was also administered to the schizophrenia group. Results: We found that the schizophrenia group presented substantially higher levels of oxidative stress than the control group, as revealed by elevated quantities of the pro-oxidants NO and MDA, and decreased levels of the antioxidants GSH, SOD and NT4/5. Interestingly, the levels of NT4/5, which have been shown to have antioxidant effects, correlated with executive functioning, as measured by two distinct tests (WCST and TMT). However, social cognition and symptom severity were not found to be associated with oxidative stress. Conclusions: We propose a protective role of NT4/5 against oxidative stress, which appears to have a potentially beneficial impact on neurocognition in schizophrenia.
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    Subjective cognitive assessments and N-back are not correlated, and they are differentially affected by anxiety and depression
    (ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD) Yapici-Eser, H; Yalcinay-Inan, M; Kucuker, MU; Kilciksiz, CM; Yilmaz, S; Dincer, N; Kilic, O; Ercan, AC; Aydemir, O
    Cognitive function (CF) is a core feature related to all psychiatric disorders. However, self-report scales of CF (SRSC) may not always correlate with CF's objective measures and may have different mediators. Tools to select for evaluating CF in diverse psychiatric populations and their determinants need to be studied. In this study, we aimed to assess the association of SRSC (Perceived Deficit Questionnaire-Depression (PDQ-D), and World Health Organization's Adult Attention Deficit Hyperactivity Disorder Self-Report Scale (ASRS) and its inattentiveness subscale) with Letter-N-back as an objective measure of CF, and to analyze their association with psychopathology. Two hundred nine (131 nonclinical, and 78 clinical with a psychiatric diagnosis of ICD10 F31-39 [mood disorders excluding Bipolar I] or F40-F49 [neurotic, stress-related or psychosomatic disorder] categories) participants were evaluated with PDQ-D, ASRS, Beck Depression Inventory (BDI), and Beck's Anxiety Inventory (BAI), and N-back. Both groups' data were included in the analysis. PDQ-D showed a small correlation with N-back scores, whereas ASRS showed no correlation. PDQ-D and ASRS showed a large correlation. Age and BAI scores significantly predicted both PDQ-D and ASRS, whereas the cognitive subscale of BDI predicted PDQ-D, but not ASRS. Only BAI scores predicted N-back results. The mediation model revealed that 2-back scores of N-back task directly affects PDQ-D scores, independent of BDI scores. However, the cognitive subscale of BDI moderated 2-back and PDQ-D association. On the contrary, BAI scores significantly mediated the association of 2-back scores with PDQ-D. The direct effect of 2-back scores in PDQ-D was insignificant in the mediation of BAI scores. Our study validates the discordance between SRSC and an objective measurement of CF. Anxiety may affect both self-report and objective measurement of CF, whereas depressive thought content may lead to higher cognitive dysfunction reports in nondemented participants.
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    Reliability and validity of Turkish version of Biological Rhythms Interview of Assessment in Neuropsychiatry
    (CUMHURIYET UNIV TIP FAK PSIKIYATRI ANABILIM DALI) Aydemir, Ö; Akkaya, C; Altinbas, K; Kora, K; Sücüllüoglu, DS; Akdeniz, F; Kalayci, F; Oral, ET; Vahip, S
    Objective: In this study, it is aimed to perform the validity and reliability of the Turkish version of Biological Rhythms Interview of Assessment in Neuropsychiatry. Methods: The study was performed with 79 bipolar type-I disorder, 26 bipolar type-II disorder and 42 major depressive disorder patients attending to mood disorder clinics of three university hospitals and one state training hospital as well as 116 university students consisting healthy control subjects. The mean duration of the illness was 15.1 years for the bipolar groups and 9,3 years for the depressive group. For concurrent validity, Pittsburgh Sleep Quality Index was used. In the statistical analyzes, internal consistency coefficient, item-total score correlations, exploratory and confirmatory factor analyzes, correlation with the other scale and ROC curve were calculated. Results: The forward and back translation of the Biological Rhythms Interview of Assessment in Neuropsychiatry was performed, and linguistic equivalence was obtained with the scale prepared. In internal consistency, the Cronbach's alpha coefficient was found to be 0.899 and item-total correlation coefficients were between 0.239 and 0.747. In the exploratory factor analysis, a total of three factors representing 56.5% of the total variance were obtained and the themes of the factors were daily activities, sleep and eating habits and interpersonal relations. In the confirmatory factor analysis, confirmatory fit index was 0.932 and root mean square of approximation was 0.065. The correlation between Biological Rhythms Interview of Assessment in Neuropsychiatry and Pittsburgh Sleep Quality Index was found to be r=0.238. In the sensitivity and specificity analysis, the area under the ROC curve was 0.876. The scale discriminated mood disorder groups from the healthy control group. Conclusion: It is shown that the Turkish version of Biological Rhythms Interview of Assessment in Neuropsychiatry which is used in the assessment of circadian rhythm and functionality is reliable and valid.
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    The Turkish Adaptation, Validity, and Reliability of the Internal States Scale
    (TURKISH NEUROPSYCHIATRY ASSOC-TURK NOROPSIKIYATRI DERNEGI) Maçkali, Z; Akkaya, C; Aydemir, Ö
    Introduction: The Internal State Scale (ISS) was developed to simultaneously assess manic and depressive symptoms in bipolar disorder. In the present study, the validity and reliability of the Turkish version of ISS (ISS-TR) were examined. The present study aimed to present the psychometric properties of this scale. Methods: The sample consisted of 200 outpatients with bipolar disorder and 49 healthy controls. Participants completed the Turkish Internal State Scale (ISS-TR), the Brief Psychiatric Rating Scale (BPRS), the Hamilton Depression Rating Scale (HDRS), and the Young Mania Rating Scale (YMRS). Results: Reliability analyses revealed that the Cronbach alfa coefficient of ISS was 0.88 for the whole sample. Item-total correlations ranged from 0.15 to 0.78. Two factors emerged as a result of factor analysis: mania and depression-well-being. Test-retest correlations were determined for the mania subscale as r=0.654, p<0.01 and for the depression-well-being subscale as r=0.356, p<0.01. The correlations between BPRS and both subscales were quite high. The correlation between HDRS and the depression-well-being subscale was higher (r=0.475) than that between HDRS and the mania subscale, whereas the correlation between YMRS and the mania subscale was higher (r=0.818) than that between YMRS and the depression-well-being subscale. It was seen that ISS could discriminate between the clinical and healthy control samples. In addition, it was observed that the mania subscale predicted a manic period more strongly, while the depression-well-being subscale predicted a depressive period better. Conclusion: ISS is a valid and reliable scale that can be used to simultaneously assess manic and depressive symptoms. It is thought that ISS will be useful in the recognition of prodromal symptoms and in the process of maintenance treatment.
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    Relation of the Nine Types of Temperament Model with Personality Disorders
    (YERKURE TANITIM & YAYINCILIK HIZMETLERI A S) Yilmaz, ED; Gencer, AG; Unal, O; Palanci, M; Kandemir, M; Selcuk, Z; Aydemir, O
    Objective: Aim of this study is to determine the correspondence between personality categories and the types making up the Nine Types of Temperament Model (NTTM) - a new temperament model which evaluates personality disorders within the context of temperament traits and maladaptive personality features-and conceptualization of NTTM types. Method: The sample group is composed of 117 participants with a personality disorder. SCID II and Nine Types of Temperament Scale (NTTS) were applied to the participants. Results: According to the findings, all NTTM types have shown significant correlation with at least one personality disorder. According to the regression analysis results, it was determined that the NTTM types were explained by personality disorders at a rate of 19-41%. Conclusions: In this study, it is found that knowing the temperament features that form the basis of an individual's personality structure is helpful to diagnose and to determine the tendency to develop personality disorders that are pathological responses to personality characteristics. In addition, this study brings up questions such as whether the individual differences between patients with the same personality disorders can be evaluated on the basis of temperament and whether it is possible to determine therapy and treatment approaches according to an individual's temperament type.
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    Reliability and validity of Turkish Version of DSM-5 Depression Scale
    (CUMHURIYET UNIV TIP FAK PSIKIYATRI ANABILIM DALI) Sücüllüoglu Dikici, D; Asçibasi, K; Aydemir, Ö
    Objective: This study aims to demonstrate the reliability and validity of Turkish version of DSM-5 Depression Scale which was developed to measure the severity of depression. Methods: The study group included 50 in-or out-pa- tients who met the criteria for major depressive disorder according to DSM-5. Sixty-three healthy volunteers without any mental or physical disease were also recruited as a control group. Beck Depression Inventory (BDI), which is the most widely used self-report scale, was used for concurrent validity. Internal consistency coefficient Cronbach alfa and item-total correlation analysis were performed for reliability. Exploratory factor analysis was used for validity, as BDI was used for concurrent validity. Results: Mean age was 39.2 +/- 11.3 and 22.4 +/- 5.8 years in the patient and control group, respectively. Sixty-one percent of the sample group (n= 66) were female. 64.8% of the group were college graduates, 19% were primary school graduates and 18.5% were high school graduates. Disease duration for major depressive disorder was 3.3 +/- 5.6 years for the patient group. For the internal consistency Cronbach alfa coefficient of the DSM-5 Depression Scale was 0.91. Item-total correlation coefficients were between 0.600.83. For the exploratory factor analysis of sample adequacy of DSM-5 Depression Scale, Kaiser-Meier-Olkin (KMO) coefficient and Bartlett coefficient was calculated as 0.91 and 608.18, respectively. Single-factor solution was obtained with an eigenvalue of 5.44, representing 60.4% of the variance. Factor loadings of the items were between 0.66-0.80. Correlation coefficient of DSM-5 Depression Scale with BDI was found as r=0.88. Conclusion: The Turkish version of DSM-5 Depression Scale is reliable and valid.