Browsing by Subject "Cell proliferation"

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    The effect of electro magnetic fields on cell behaviour; [Elektro Manyetik Alanlarin Hücre Davranisina Etkisi]
    (Institute of Electrical and Electronics Engineers Inc., 2017) Tuglu M.I.; Gulbagca F.; Sal D.H.; Saygili S.; Sonmez P.K.; Aydemir I.; Ozkut M.; Ozturk S.; Gumusay M.; Kaya A.; Keskin N.
    The biologic effects of electomagnetic fields application on medical field has been increased. Their effect on medical treatment depends on cell behaviour which can be observed by in vivo and in vitro studies. Their effect on the stem cells and the cell lines and the organs of experimental animals with morphological alterations are helpful to understand cell behaviour. The behaviour of the cells can be analyse at ultrastructural level by scaning electron microscopy. Application of electomagnetic fields cause increase of proliferation, migration and improvement of wound healing with beneficial effects while they cause oxidative stress and cell death including apoptosis for cancer cells in different types of cell line. The minimal side effect with maximum beneficial treatment of these products suggest that they could be very useful for clinical trials. © 2016 IEEE.
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    Compression of the effect of pulsed electromagnetic field and pulsed radio frequency energy on wound healing in rats; [Darbeli elektromanyetik alan ve darbeli radyofrekans uygulamalarinin siçanlarda yara iyileşme etkilerinin karşilaştirmasi]
    (Institute of Electrical and Electronics Engineers Inc., 2017) Gumusay M.; Gulbagca F.; Saygili S.; Aydemir I.; Kaya A.; Tuglu M.I.
    Delayed or not sufficiently good wound healing is a significant problem in medical treatment is needed to support in order to improve healing. Low frequency electromagnetic field (EMF) applications are seems to give this support. Disturbed vascularization, connective tissue formation, matrix exchange, and inflammation process in the wound environment are modified after EMF applications compared with control groups. Deteriorations in these factors which can be returned with the electrical impulses, DNA synthesis, transcription and transforms of protein synthesis, increasing of fibroblasts and endothelial cell proliferation indicate the presence of EMF mechanisms. Since the application and ambient conditions are kept constant but the type of the application has been changed in our study, it was provided that pulsed radio frequency energy (PRFE) is more effective and has more long-term improvement compared to pulsed electromagnetic fields (PEMF). The effects of these applications on cells and understanding of the mechanisms of the behavior will be much more significant and meaningful contribute to the treatment. © 2016 IEEE.
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    Trends and Risk of HIV/AIDS in Turkey and Its Cities
    (Springer, 2021) Hincal E.; Sayan M.; Kaymakamzade B.; Şanlidağ T.; Sa’ad F.T.; Baba I.A.
    We developed a mathematical model to study the dynamics of HIV/AIDS in Turkey and its environs. Two equilibrium points were found and local stability analysis of the equilibria was conducted. It was found that the stability of the equilibria depend on a threshold quantity; the basic reproduction ratio R0. When R0≤ 1, the disease free equilibrium is locally asymptotically stable and disease dies out. When R0≥ 1, the endemic equilibrium is locally asymptotically stable and disease persist. We considered the dynamics of the disease in 25 cities of Turkey and found out that the basic reproduction ratio for 17 cities is greater than one, while 8 of them have less than one. This indicates there is going to be epidemics in these 17 cities and the disease will die out in the remaining cities. The results also indicated that some of the cities (with bigger basic reproduction ratio) are at bigger risk than the others. There is need for quick intervention by the relevant authorities, especially in the cities with greater risk of the disease. © 2021, Springer Nature Switzerland AG.
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    Boswellia sacra essential oil manages colon cancer stem cells proliferation and apoptosis: a new perspective for cure
    (Bellwether Publishing, Ltd., 2021) Becer E.; Kabadayı H.; Başer K.H.C.; Vatansever H.S.
    Boswellia sacra Flueck essential oil is obtained from frankincense obtained from Boswellia sacra trees. The aim of this study was to investigate the in vitro anti-cancer activity of Boswellia sacra (BS) essential oil in CD133+ and CD133- Colo-320 cells. Essential oil was analyzed by GC-MS. CD133+ cells, cancer stem cells, were obtained from the Colo-320 by the MiniMACS system. Cytotoxicity were evaluated with MTT assay. Anti-cancer activity of BS essential oil was investigated by immunocytochemistry. 41 compounds were identified in the essential oil. 1:2 dilution BS essential oil was found to be active against all the cells for 24 h incubation. β-catenin immunoreactivity was significantly decreased in both BS essential oil-treated CD133+ and CD133- Colo-320 cells. Caspase-3 immunoreactivity significantly increased in BS essential oil-treated CD133- Colo-320 cells. We conclude that BS essential oil decreased β-catenin signaling molecules which play a crucial role in cancer cell proliferation. BS essential oil promoted apoptosis in CD133- Colo-320 cells. © 2020 Informa UK Limited, trading as Taylor & Francis Group.