Browsing by Subject "Cell-be"

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    Surface Area of Graphene Governs Its Neurotoxicity
    (American Chemical Society, 2023) Taşdemir Ş.; Morçimen Z.G.; Doǧan A.A.; Görgün C.; Şendemir A.
    Due to their unique physicochemical properties, graphene and its derivatives are widely exploited for biomedical applications. It has been shown that graphene may exert different degrees of toxicity in in vivo or in vitro models when administered via different routes and penetrated through physiological barriers, subsequently being distributed within tissues or located within cells. In this study, in vitro neurotoxicity of graphene with different surface areas (150 and 750 m2/g) was examined on dopaminergic neuron model cells. SH-SY5Y cells were treated with graphene possessing two different surface areas (150 and 750 m2/g) in different concentrations between 400 and 3.125 μg/mL, and the cytotoxic and genotoxic effects were investigated. Both sizes of graphene have shown increased cell viability in decreasing concentrations. Cell damage increased with higher surface area. Lactate dehydrogenase (LDH) results have concluded that the viability loss of the cells is not through membrane damage. Neither of the two graphene types showed damage through lipid peroxidation (MDA) oxidative stress pathway. Glutathione (GSH) values increased within the first 24 and 48 h for both types of graphene. This increase suggests that graphene has an antioxidant effect on the SH-SY5Y model neurons. Comet analysis shows that graphene does not show genotoxicity on either surface area. Although there are many studies on graphene and its derivatives on their use with different cells in the literature, there are conflicting results in these studies, and most of the literature is focused on graphene oxide. Among these studies, no study examining the effect of graphene surface areas on the cell was found. Our study contributes to the literature in terms of examining the cytotoxic and genotoxic behavior of graphene with different surface areas. © 2023 American Chemical Society. All rights reserved.
  • No Thumbnail Available
    Item
    Design and production of dye-synthesized solar cells with FTO/TiO2/ferroelectric dye/electrolyte/Pt/FTO architecture
    (Springer, 2023) Coban Ozkan D.; Turk A.; Celik E.
    A new approach for the application of dye-synthesized solar cells is realized by using perovskite and single oxide micro/nanopowders. With respect to the literature, the desired energy efficiency of dye-synthesized solar cells is a priori established as perovskite and single oxide micro/nanopowders in a composite structure. In the present work, in order to produce dye-synthesized solar cells with FTO/TiO2/ferroelectric/dye/electrolyte/Pt/FTO architecture, their precursor solutions were prepared by using nitrate-based salts, solvents, and chelating agents. The obtained gel films were dried at 200 °C for 2 h and then annealed at temperatures of 500 °C and 850 °C for 2 h in the air. TiO2 and LaFeO3 powders were characterized through DTA-TGA, FTIR, XRD, SEM, and UV-Vis spectrometer machines. In line with the results obtained, dye-sensitized solar cell production, which can also be called ferroelectric photovoltaic cells with a combination of TiO2, was produced. It was found that the production of continuously applicable and sustainable dye-sensitive solar cells using LaFeO3 with together TiO2 powders can be useful as innovative and futuristic approaches. © 2023, The Author(s) under exclusive licence to Australian Ceramic Society.