Browsing by Subject "Homeostasis"

Now showing 1 - 4 of 4
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    Should children with infection be tested for lipid, lipoprotein and apolipoprotein?
    (1998) Işcan A.; Yiǧitoǧlu R.; Onaǧ A.; Vurgun N.; Ari Z.; Ertan P.; Şengil A.Z.
    The lipid profile is known to alter in patients with infection, but there has not been a study of the apolipoprotein levels in serum of otherwise healthy children during infection. Lipids, lipoproteins, apolipoproteins A-1 and B and lipoprotein (a) were evaluated prospectively in 31 consecutive children, aged 4-15 years, who were admitted to the hospital with bacterial pharyngitis. The degree of dyslipidemia associated with bacterial pharyngitis was assessed using each child as his/her own control and by comparison with 79 healthy children who had not had an infection during the past 3 months. Serum total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apolipoprotein A-1 and apolipoprotein B levels were significantly decreased during the symptomatic phase of the disease, whereas the serum triglyceride level was slightly elevated. Serum lipoprotein (a) concentration did not change significantly. In conclusion, it is suggested that serum lipids, lipoproteins and apolipoproteins should not be assessed during infection because of the possible transient changes of these parameters during infection or inflammation.
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    The association between insulin resistance and hepatic fibrosis in patients with chronic hepatitis C: An observational, multicenter study in Turkey
    (Turkish Society of Gastroenterology, 2014) Dökmeci A.; Üstündaʇ Y.; Hulagu S.; Tuncer I.; Akdoʇan M.; Demirsoy H.; Köklü S.; Güzelbulut F.; Doʇan I.; Demir A.; Akarsu M.; Yüceyar H.; Özdogan O.C.; Özdener F.; Erdoʇan S.
    Background/Aims: To evaluate the association between insulin resistance and hepatic fibrosis in patients with chronic hepatitis C.; Materials and Methods: A total of 104 chronic hepatitis C patients were included in this non-interventional, open-label, observational, multicenter, cross-sectional study conducted at 20 gastroenterology clinics in Turkey. The primary end point was the correlation between stage of hepatic fibrosis and insulin resistance evaluated via the homeostasis model of assessment-insulin resistance index. Confounders of hepatic fibrosis and insulin resistance were the secondary end points.; Results: The mean age of patients was 52.8 years; 65.4% were female. Type 2 diabetes was present in 6.8% and insulin resistance noted in 38.0% of patients. Further, 45.7% of the patients had mild (A0/A1) and the remaining had moderate/severe (A2/A3) hepatic necroinflammatory activity. Patient distribution according to Metavir fibrosis stage was as follows: F0/F1 (57.0%); F2 (6.5%); F3 (23.7%); and F4 (12.9%). A univariate analysis revealed significant positive correlations between Metavir fibrosis stage and insulin resistance (r=0.297; p=0.007). Logistic regression analysis showed that significant predictors of insulin resistance were high alanine transaminase levels (odds ratio, 0.97; 95% confidence interval, 0.944-0.997) and liver fibrosis stage (odds ratio, 0.114; 95% confidence interval, 0.021-0.607).; Conclusion: Our findings revealed significant associations between insulin resistance and hepatic fibrosis. © 2014 by The Turkish Society of Gastroenterology.
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    Simulation of glucose regulating mechanism with an agent-based software engineering tool
    (Balikesir University, 2019) Emek, Sevcan; Evren, Vedat; Bora, Şebnem; Emek, Sevcan; Fakülteler > Mühendislik Ve Doğa Bilimleri Fakültesi > Bilgisayar Mühendisliği Bölümü
    This study provides a detailed explanation of a regulating mechanism of the blood glucose levels by an agent-based software engineering tool. Repast Simphony which is used in implementation of this study is an agent-based software engineering tool based on the object-oriented programming using Java language. Agent-based modeling and simulation is a computational methodology for simulating and exploring phenomena that includes a large set of active components represented by agents. The agents are main components situated in space and time of agent-based simulation environment. In this study, we present hormonal regulation of blood glucose levels by our improved agent-based control mechanism. Hormonal regulation of blood glucose levels is an important process to maintain homeostasis inside the human body. We offer a negative feedback control mechanism with agent-based modeling approach to regulate the secretion of insulin hormone which is responsible for increasing the blood glucose levels. The negative feedback control mechanism run by three main agents that interact with each other to perform their local actions in the simulation environment. The result of this study shows the local behavior of the agents in the negative feedback loop and illustrates how to balance the blood glucose levels. Finally, this study which is thought a potential implementation of agent-based modeling and simulation may contribute to the exploration of other homeostatic control systems inside the human body.
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    Thiol/disulfide homeostasis in medication-naive children and adolescents with obsessive–compulsive disorder
    (Elsevier Ltd, 2021) Ozkan Y.; Kandemir H.; Yalın Sapmaz S.; Taneli F.; Ozdemir H.; Gozaçanlar Ozkan O.
    Obsessive–compulsive disorder (OCD) causes significant psychic distress and affects children's social and academic functioning. Approximately 80% of OCD cases begin in childhood. Earlier onset is associated with more severe OC symptoms, poorer treatment response, and a more unfavorable clinical course. A particular oxidative stress marker, thiol/disulfide homeostasis, using a new, comparatively inexpensive, easily calculated, easily accessible, repeatable, and fully automated method was investigated between pediatric patients diagnosed with OCD and a healthy control group in this study. This study is the first to address this subject in pediatric patients with OCD and aims to contribute to our knowledge of the etiopathogenesis and treatment of pediatric OCD. The study included children with OCD (n = 35, 52.2%) (drug free, comorbidity free) between 11 and 18 years of age and age- and sex-matched healthy controls (n = 32, 47.8%). The total thiol (p = 0.025) and disulfide (p = 0.001) levels and the disulfide/native thiol (p = 0.001) and disulfide/total thiol ratios (p = 0.001) were significantly different between the groups. Also, in the patient group, biochemical analysis revealed that the disulfide level (p = 0.05) and the disulfide/native thiol (p = 0.034) and disulfide/total thiol ratios (p = 0.039) differed significantly according to the presence of a family history of psychiatric disorders. Consequently, the results of our study show that thiol/disulfide homeostasis may affect the etiopathogenesis of pediatric OCD and can be utilized as a new method when evaluating oxidative stress. © 2021 Elsevier Ltd