Browsing by Subject "Hydrogels"

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    Flow Behavior and Drug Release Study of Injectable Pluronic F-127 Hydrogels containing Bioactive Glass and Carbon-Based Nanopowders
    (Springer, 2020) Deliormanlı A.M.; Türk M.
    Injectable biomaterials have gained significant attention in recent years since they can be delivered to the defect sites through minimally-invasive approaches. In this work, thermo-responsive injectable hydrogels containing borate-based bioactive glass particles and carbon-based nanopowders were designed for bone tissue engineering applications. For this purpose, mixtures of Pluronic F127 block-copolymer and 13-93B3 bioactive glass particles with different sizes (2.3 µm, 14 µm, 150 µm) were prepared in aqueous medium and their in situ gelation were investigated through rheological measurements as a function of temperature. Effects of graphene nanopowders and multi-walled carbon nanotubes on the flow behavior of the designed hydrogel system were also investigated. Results revealed that viscosity of the prepared hydrogel system was strongly dependent on the temperature and the bioactive glass particle size. Inclusion of graphene and multi-walled carbon nanotubes in this system caused a further increase in viscosity. All of the hydrogel compositions designed in the study showed shear thinning flow behavior which is a crucial parameter for injectability. Drug release studies showed that the addition of bioactive glass and carbon-based nanoparticles improved the drug release behavior of the prepared hydrogels. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
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    Effective removal of heavy metals from an aqueous solution with poly(N-vinylimidazole-acrylamide) hydrogels
    (Bellwether Publishing, Ltd., 2021) Tirtom V.; Dinçer A.
    In this study poly(N-vinylimidazole-acrylamide) p(N-VI-AAm) hydrogels were prepared as an adsorbent for adsorptive removal of lead (II) and copper (II) ions from aqueous solution. Adsorption studies showed that poly(N-vinylimidazole-acrylamide) p(N-VI-AAm) hydrogels can  be effectively used to remove heavy metals. Hydrogel characterization was done by FTIR and SEM. The effect of the removal conditions such as contact time, pH, temperature, and initial metal ion concentration on the Pb (II) and Cu (II) ions binding was also tested. Maximum adsorption was achieved at 30°C and 35°C for Pb (II) and Cu (II) after 24 h, respectively. Experimental capacities were calculated as 262 and 53 mg g−1 for lead and copper, respectively. The isotherms were analyzed with Langmuir and Freundlich models. Briefly, this economic and high adsorption performance poly(N-VI-AAm) hydrogel is a promising candidate for sewage disposal and metal pollution treatment. © 2020 Taylor & Francis Group, LLC.
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    Topical systems for the controlled release of antineoplastic Drugs: Oxidized Alginate-Gelatin Hydrogel/Unilamellar vesicles
    (Academic Press Inc., 2023) Stagnoli S.; Garro C.; Ertekin O.; Heid S.; Seyferth S.; Soria G.; Mariano Correa N.; Leal-Egaña A.; Boccaccini A.R.
    The efficacy of chemotherapeutic procedures relies on delivering proper concentrations of anti-cancer drugs in the tumor surroundings, so as to prevent potential side effects on healthy tissues. Novel drug carrier platforms should not just be able to deliver anticancer molecules, but also allow for adjustements in the way these drugs are administered to the patients. We developed a system for delivering water-insoluble drugs, based on the use of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), or bis(2-ethylhexyl) sulfosuccinate benzyl-n-hexadecyldimethylammonium (BHD-AOT), embedded into oxidized alginate-gelatin (ADA/Gel) hydrogel, emulating a patch for topic applications. After being loaded with curcumin, cancer cells such as human colorectal adenocarcinoma (HCT116 and DLD-1) and melanoma cell lines (MEL501), and non-malignant cells such as mammary epithelial cell lines (NMuMG) and embryonal fibroblasts (NIH 3T3 or NEO cells) were analyzed for biocompatibility and cytotoxic effects. The results show that the proposed system can load comparatively higher concentrations of the drug (with respect to other nano/microcarriers in the literature), and that it can enhance the likelihood of the drug being uptaken by cancer cells instead of non-malignant cells. These assays were complemented by diffusion studies across the stratum corneum of rat skin, with the aim of determining the system's efficiency during topical application. Finally, the stability of the patch was tested after lyophilization to determine its potential pharmaceutical use. As a whole, the combined system represents a highly reliable and robust method for embedding and delivering complex insoluble chemotherapeutical molecules, and it is less invasive than other alternative methods in the literature. © 2022 Elsevier Inc.