Browsing by Subject "INTERFERON"

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    Impact of Education Provided by Nurses on Quality of Life, Anxiety, and Depression in Patients Receiving Hepatitis C Virus Therapy
    (LIPPINCOTT WILLIAMS & WILKINS) Cinar, S; Ozdogan, OC; Alahdab, Y
    The aim of this study was to determine the impact of education provided by a nurse on quality of life, anxiety, and depression in patients receiving hepatitis C virus (HCV) therapy. The total number of patients receiving HCV treatment was 25 patients (18 females and 7 males). Organized patient lectures addressed transmission routes of HCV, effects of virus on the liver, interferon treatment, treatment complications and care, and psychosocial problems faced by patients with HCV and their families. Lectures were followed by interviews in small groups including 3-4 patients each and repeated 3 months after. Data were collected by patient surveys, Hospital Anxiety-Depression Scale, and Short Form (SF)-36 Health Survey (SF-36). There were no significant differences between pre- and posteducation for the SF-36 domains, namely role physical, health perception, social functioning, role emotion, and mental health, whereas there were significant differences between pre- and posteducation for the SF-36 domains, namely physical function, bodily pain, and vitality. Pre-education depression and anxiety scores were higher than posteducation depression and anxiety scores. Specific educational programs provided by nurses improved patients' quality of life and decreased anxiety and depression in patients receiving HCV therapy. These findings support the importance of educational programs provided by nurses for HCV patients.
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    Down-regulation of the auto-aggressive processes in patients with hypothyroid Hashimoto's thyroiditis following substitutive treatment with L-thyroxine
    (JOHN LIBBEY EUROTEXT LTD) Guclu, F; Ozmen, B; Kirmaz, C; Kafesciler, SO; Degirmenci, PB; Taneli, F; Hekimsoy, Z
    Background. Hashimoto's thyroiditis is a chronic, organ-specific autoimmune disease. It is the most common cause of primary hypothyroidism during the adolescent period, via autoimmune thyroid tissue destruction, affecting 2% of the population. The pathogenesis of Hashimoto's thyroiditis involves a complex interaction between predisposing genetic and environmental factors. Objective. In this study, we wanted to investigate the role of cytokines such as IL-2, IL-4, IL-12 and IFN-gamma in the pathogenesis of the disease, and the changes to cytokine levels brought about by treatment with L-thyroxine. Methods. Sixty five female patients, aged 18-73 years with Hashimoto's thyroiditis, referred to the Celal Bayar University Medical Faculty Endocrinology out-patients clinic, were included in this study. After a 10-12 week period of L-thyroxine treatment, all patients were restored to the euthyroid state. At the beginning and end of the treatment period, serum-free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), autoantibodies against thyroid peroxidase (anti-TPO), autoantibodies against thyroglobulin (anti-Tg) levels were measured using a chemiluminecent, immunometric method, and cytokine levels were measured using ELISA. Results. There was a statistically significant decrease in the serum levels of TSH (p < 0.0001) and a concomitant increase in FT4 serum levels (p < 0.0001). Also, during the post-treatment period, serum levels of anti-Tg (p < 0.01) and anti-TPO (p < 0.001) were significantly lower than during the pre-treatment period. A statistically significant decrease was shown for interleukin (IL)-12 serum levels during the post-treatment period (p < 0.001). However, the decrease in interferon (IFN)-gamma serum levels was not statistically significant (p = 0.276). On the other hand, no change was demonstrated in serum IL-2 and IL-4 levels (p = 0.953 and p = 0.313, respectively) after treatment with L-thyroxine. Conclusion. Considering that our study involved a 10-12 week period of treatment, the statistically significant decrease in serum IL-12 levels, and the statistically non-significant decrease in IFN-gamma levels, might indicate that a T helper type 1 inflammatory process had been halted or slowed down.