Browsing by Subject "IRON-OXIDE NANOPARTICLES"

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    Synthesis and in vitro characterization of superparamagnetic γ-Fe2O3-containing 13-93 bioactive glasses for bone cancer therapy
    (ELSEVIER SCI LTD) Saatci, M; Deliormanli, AM; Atmaca, H
    Osteosarcoma is one of the most common types of bone cancer, which generally starts in the long bones. In this study, superparamagnetic maghemite-containing (2, 5, 10, 20 wt%) bioactive glass powders were prepared for the treatment of osteosarcoma. For this purpose, maghemite nanoparticles were synthesized using the co -precipitation technique, and maghemite-containing bioactive glass-ceramic composites were fabricated through the sol-gel process. The structural, morphological, thermal, and magnetic properties and the in vitro bioactivity of the prepared bioactive glasses were investigated. In vitro cytotoxicity was examined using SaOS-2 and MC3T3-E1 cells. The fluorouracil (5-FU) release behavior of the studied bioactive glass powders was also monitored in phosphate-buffered saline as a function of time. Results revealed that synthesized maghemite nanoparticles as well as the maghemite-containing bioactive glass-ceramic composites have superparamagnetic properties. They have high bioactivity, with up to 5 wt% maghemite content. Prepared bioactive glass com-posites have no cytotoxicity against osteosarcoma and pre-osteoblast cells at low concentrations. Drug-loaded bioactive glass powder showed sustained release behavior. Overall results indicated that prepared glass com-posites have a high potential to be used in magnetic hyperthermia and anticancer drug release applications for the treatment of bone cancer.
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    A novel radiolabeled graft polymer: Investigation of the radiopharmaceutical potential using Albino Wistar rats
    (PERGAMON-ELSEVIER SCIENCE LTD) Avcibasi, U; Ates, B; Ünak, P; Gümüser, FG; Gülcemal, S; Ol, KK; Akgöl, S; Tekin, V
    Fe3O4 magnetic graft-Lys-poly(HEMA) was synthesized, labeled with Tc-99m for the first time and its radiopharmaceutical potential was investigated using animal models in this study. Quality control procedures were carried out using thin layer radiochromatography. The labeling yield of radiolabeled polymer was found to be about 100%. Then, stability and lipophilicity were determined. The lipophilicity of Tc-99m labeled Fe3O4 graft-Lys-poly(HEMA) was found to be 3.77. The serum stability experiments demonstrated that approximately 100% of radiolabeled polymer existed as an intact complex in the rat serum within 240 min. Biodistribution of radiolabeled magnetic graft-Lys-poly(HEMA) was performed on female Albino Wistar rats by scintigraphy and biodistribution studies. High uptake was seen in the stomach, the pancreas, brain, ovarian, intestines and the breast.
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    Fabrication and characterization of novel multifunctional superparamagnetic and fluorescent bioactive glasses for biomedical applications
    (ELSEVIER SCIENCE SA) Deliormanli, AM; Rahman, B
    Magnetic-fluorescent nanosystems have wide applications in the biomedical field due to their dual ability of unique biomolecular fluorescent recognition and magnetic modes. In this study fabrication of superparamagnetic-fluorescent bioactive glasses in the form of particle, nanofiber, and 3D scaffold was performed by the inclusion of maghemite (& gamma;-Fe2O3) nanoparticle and photoluminescent rare earth element ions (Eu3+, Gd3+, and Yb3+). Bioactive glasses in the form of particle, nanofiber, and 3D scaffolds were manufactured using sol-gel, electrospinning, and robocasting techniques, respectively. Morphological, structural, magnetic, and luminescence properties of the fabricated bioactive glasses have been investigated comprehensively using electron microscopy, x-ray diffractometer, vibrating sample magnetometer, Fourier transform infrared, and fluorescence spectrometers. The compressive strength of the robocast 3D glass scaffolds was measured. In vitro hydroxyapatite deposition on the surface of the bioactive glasses soaked in simulated body fluid for various times up to 28 days was also examined. Results showed that all of the bioactive glasses prepared in the study with different morphological characteristics have superparamagnetic properties. Saturation magnetization (Ms) values of the glasses were in the range of 7.20-12.50 emu/g. Additionally, all of the studied glass samples showed fluorescence behavior. The highest photoluminescence emission peak intensity was recorded for the Eu3+-doped robocast 3D glass scaffolds which is followed by nanofibrous and particulate forms of bioactive glass. Results of the in vitro bioactivity experiments showed that hydroxyapatite formation occurred on all of the bioactive glass samples and the highest hydroxyapatite formation rates were obtained for the fibrous glass samples due to their higher surface area.
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    Synthesis, characterization, and 5-fluorouracil release behavior of superparamagnetic ?-Fe2O3/ZnO hetero-nanostructures for biomedical applications
    (ELSEVIER SCI LTD) Saatci, M; Deliormanli, AM
    In this study, superparamagnetic maghemite (gamma-Fe2O3) nanosystems in the form of nanoparticles were fabricated through the co-precipitation method at different processing conditions. Additionally, novel gamma-Fe2O3/ZnO het-erostructures were fabricated using zinc acetate as the zinc source and polyvinyl pyrrolidone (PVP), and eth-ylenediaminetetraacetic acid (EDTA) as the capping agents. The results revealed that the size of the crystallites of the prepared maghemite nanopowders was between 6 nm and 7.8 nm depending on the synthesis temperature. The saturation magnetization value of maghemite nanopowders synthesized at 90 degrees C was measured to be 51.58 emu/g without hysteresis with negligible coercivity. FTIR analysis results proved the presence of ZnO in the maghemite core-based nanosystem. The formation of a ZnO coating using zinc acetate in the presence of PVP and EDTA as a capping agent caused a decrease in magnetization value to 12 emu/g. A ZnO coating provided better dispersion of maghemite nanoparticles and it also affected the drug (5-FU) delivery behavior. ZnO-coated nanoparticles showed prolonged and sustained drug release additionally, they continue to release the drug after 410 h. The 5-FU release kinetics of the prepared heterogeneous nanostructures fitted well with the Korsmeyer-Peppas model.
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    NANOMATERIALS: PROMISING STRUCTURES FOR THE MANAGEMENT OF ORAL CANCER
    (ELSEVIER SCIENCE BV) Eskiizmir, G; Ermertcan, AT; Yapici, K