Browsing by Subject "Nanocomposite fibers"

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    Preparation and mineralization of 13-93 bioactive glass-containing electrospun poly-epsilon-caprolactone composite nanofibrous mats
    (SAGE Publications Ltd, 2019) Konyalı R.; Deliormanlı A.M.
    In this study, silicate- based 13-93 bioactive glass (BG) /poly-ε-caprolactone (PCL) nanocomposite fiber mats were fabricated through electrospinning. To prepare composites, amorphous electrospun bioactive glass nanofibers (BGFs) or melt-derived microscale bioactive glass particles (BGPs) were incorporated into the PCL matrix. In vitro mineralization ability of the prepared fibrous mats was assessed in simulated body fluid under static conditions. The results revealed that it is possible to prepare bead-free continuous nanofibers using PCL-acetone solution at specified PCL concentrations (8 and 10 wt%). Nanofibers with almost uniform diameters were produced using 10 wt% PCL solution. Incorporation of BG in the form of particle or fiber into the PCL matrix was made between 1 wt% and 10 wt%. The results showed that the diameter of BGP-containing composite fibers was higher compared to BGF-containing composite scaffolds. The addition of BG to the PCL matrix both in the form of powder and fiber enhanced hydroxyapatite formation in the fibrous scaffolds. The amount of calcium phosphate–based material formation was higher in glass particle–containing samples compared to glass fiber–containing PCL scaffolds. Additionally, the degradation rate in phosphate buffer and silicium ion release amount of BGP-containing PCL fibers was higher compared to BGF-containing PCL fibers. It was concluded that fibrous composite scaffolds prepared in this study could have potential in tissue engineering applications. © The Author(s) 2018.
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    Bioactive glass/hydroxyapatite- containing electrospun poly (ε-Caprolactone) composite nanofibers for bone tissue engineering
    (Springer International Publishing, 2019) Deliormanlı A.M.; Konyalı R.
    In this study, bioactive glass and hydroxyapatite (HA)-containing poly(ε-caprolactone) (PCL) nanocomposite fiber mats were fabricated through electrospinning. For this purpose, microscale bioactive glass (silicate-based 45S5 and borate-based 13-93B3 compositions) or HA particles (at 10 wt%) were incorporated into the PCL matrix. The fabricated biocomposite fibers were investigated in terms of morphological and chemical properties. An in vitro mineralization assay in simulated body fluid was performed to understand the capability of the composite electrospun fibers to induce the formation of hydroxycarbonate apatite. Results showed that the diameter of the electrospun PCL-based fibrous scaffolds increased by the inclusion of bioactive glass or HA particles. All of the fibrous mats prepared in the study showed hydrophobic character. Relatively high contact angles (> 90°) obtained for fibrous scaffolds was attributed to the high porosity and surface roughness. Bioactive glass or HA addition to the PCL matrix enhanced the bioactivity of the fibrous scaffolds. The deposition rate of calcium phosphate-based material precipitates was higher on the surface of HA-containing samples compared to bioactive glass-containing PCL scaffolds. Additionally, mineralization ability of borate-based 13-93B3 glass-containing samples was higher compared to 45S5 glass-containing PCL fibers. The biocomposite fibrous scaffolds prepared in the study may find applications in wound healing as wound dressing and in bone tissue engineering. © 2018, Australian Ceramic Society.