Browsing by Subject "Positron Emission Tomography Computed Tomography"

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    Vulvar Cancer with Bilateral Axillary Lymph Node Metastasis
    (Taylor and Francis Ltd, 2016) Hasdemir P.S.; Aras F.; Solmaz U.; Guvenal T.
    [No abstract available]
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    Molecular subtypes of invasive breast cancer: Correlation between PET/computed tomography and MRI findings
    (Lippincott Williams and Wilkins, 2020) Akin M.; Orguc S.; Aras F.; Kandiloglu A.R.
    Objective The aim of the study was to investigate the diagnostic value of fluorodeoxyglucose-18 (FDG)-PET/computed tomography (CT) and MRI parameters in determining the molecular subtypes of invasive breast cancer. Methods Data from 55 primary invasive breast cancer masses in 51 female patients who underwent pre-treatment PET/CT and MRI scans, and histopathological diagnosis at the authors' center were retrospectively reviewed. The relationship between FDG-PET/CT and MRI parameters, including maximum and mean standard uptake values (SUVmax and SUVmean, respectively), mean metabolic index (MImean) and metabolic tumor volume (MTV) values obtained from FDG-PET, and shape, margin, internal contrast-enhancement characteristics, kinetic curve types, functional tumor volume (FTV), apparent diffusion coefficient (ADC) values obtained from MRI was evaluated. Subsequently, differences among molecular subtypes (i.e. luminal A, luminal B, c-erbB-2 positive, and triple-negative) in terms of PET/CT and MRI parameters were evaluated. Results The luminal B subtype of invasive breast cancer had higher SUVmax and SUVmean (P = 0.002 and P = 0.017, respectively) values than the luminal A subtype. In addition, the triple-negative subtype had a higher SUVmax (P = 0.028) than the luminal A subtype. There was a statistically significant positive correlation between pathological tumor volume (PTV) and SUVmean (P = 0.019, r = 0.720). SUVmax and ADC were negatively correlated (P = 0.001; r =-0.384). A very strong positive correlation was detected between MTV and FTV (P = 0.000; r = 0.857), and between MTV and PTV (P = 0.006, r = 0.796), and between FTV and PTV (P = 0.006, r = 0.921). Conclusion Results of the present study suggest that SUVmax was superior to MRI findings in predicting molecular subtypes and that MRI was superior to PET/CT in predicting PTV. © 2020 Lippincott Williams and Wilkins. All rights reserved.
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    Predictive value of quantitative metabolic tumor volume and metabolic index analysis in lung cancer stereotactic radiotherapy with F-18 FDG PET/CT
    (Verduci Editore s.r.l, 2022) Aras F.; Olmezoglu A.
    OBJECTIVE: The objective of this study was to investigate predictive value of quantitative metabolic tumor volume and metabolic index analysis in lung cancer stereotactic radiotherapy with F-18 FDG PET/CT. PATIENTS AND METHODS: Overall, 94 early-stage non-small cell lung cancer (NSCLC) patients who were administered stereotactic radiotherapy were included in the study. RESULTS: Most of the study patients were male (91.5%). Mean age of the patients was 68.5 ± 9.0 years. The primary lung tumor was located centrally and peripherally in 25 (26.6%) and 69 (73.4%) of the patients, respectively. The median gross tumor volume (GTV) was 16.2 cc [interquartile range (IQR): 7.1-32.9]. Whereas all patients who had peripheral tumors survived, 17 patients with central tumors (70.8%) died during the study period (p = 0.001). Biologically effective dose (BED10) values were significantly higher in patients who had peripheral tumors compared with patients with central tumors (p = 0.001). Significantly more patients died in patients who had BED values below 100 Gy compared to patients who had BED values over 100 Gy (p = 0.001). The survival distributions for the two groups were significantly different (p < 0.001). Only GTV and Pretreatment SUVmean appeared as significant predictors of mortality. BED10 values showed a significant and strong positive correlation with total radiation dose, whereas it showed a significant strong negative correlation with number of fractions. CONCLUSIONS: The use of repeated 18F-FDG PET to assess survival early during stereotactic radiotherapy is possible in patients with early-stage non-small cell lung cancer. A decrease in GTV and pretreatment SUVmean according to F-18 FDG PET/CT uptake by the primary tumor correlates with survival. © 2022 Verduci Editore s.r.l. All rights reserved.