Browsing by Subject "Staphylococcus epidermidis"
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Item Is skin disinfection with 10% povidone iodine sufficient to prevent epidural needle and catheter contamination?(W.B. Saunders, 2003) Yentur E.A.; Luleci N.; Topcu I.; Degerli K.; Surucuoglu S.Background and Objectives: Epidural space infection is a potential complication of epidural catheter placement. In this study, we investigated the incidence of epidural needle and catheter contamination after skin surface disinfection with 10% povidone-iodine (PI). Methods: Sixty seven patients having surgery under epidural anesthesia were enrolled in this prospective study. After preparation with 10% PI, skin swab cultures were taken from the site of catheter insertion. Epidural needles were cultured immediately after epidural catheters were placed. Catheters were removed at 48 hours and 2 to 3 cm of the distal tips were cultured as well. Results: Fifty-six skin swabs, 52 epidural needles, and 48 catheters were cultured. Although only 3.5% (2) colonization was observed on skin surface cultures, 34.6% (18) of the epidural needles and 45.8% (22) of the catheters were colonized. No systemic or local infection was observed. Conclusion: Our results suggest that despite skin surface disinfection with PI, there is still significant risk for contamination of needles and catheters during epidural catheterization.Item Antimicrobial screening of some Turkish medicinal plants(2007) Oskay M.; Sari D.Ethanol extracts of 19 Turkish medicinal plants, used in the traditional system of medicine, were investigated for their antimicrobial activity against 14 pathogenic bacterial species and a yeast, Candida albicans, using the agar well diffusion method. Anticandidal activity was detected in 10 plant extracts. Extracts of Eucalyptus camuldulensis (leaves), Rosmarinus officinalis (leaves), Ecballium elaterium (leaves, fruits; 2:1, v/v), Liquidambar orientalis (leaves), Cornus sanguinea (leaves, flowers, stems; 2:1:1, v/v/v), Vitis vinifera (leaves, raw fruits, young branches; 2:1:1, v/v/v), Inula viscosa (leaves), Hypericum perforatum (leaves, flowers, stems; 2:1:1, v/v/v), and Punica granatum (leaves, flowers; (2:1, v/v) showed broad-spectrum antimicrobial activity with inhibition zones ranging from 4 to 34 mm. The most resistant organisms were Escherichia coli, Candida albicans, Pseudomonas fluorescens, Bacillus subtilis ATCC 6683, and Enterobacter faecalis ATCC 29212, and the most susceptible species were Proteus vulgaris ATCC 6997, Salmonella typhimurium CCM 5445, Staphylococcus epidermidis ATCC 12228, and Serratia marcescens CCM 583, respectively. The minimum inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) were determined for the seven highly active plants that showed antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 95047 (MRSA), E. coli, and C. albicans. The MICs of active extracts ranged from 8 to 14.2 mg/mL while the MBCs were 14.2 to 24.4 mg/mL. © 2007 Informa Healthcare.Item Apolar constituents of some biologically active dianthus species from Western Anatolia(Springer New York, 2009) Durucasu I.; Mutlu K.; Sik L.; Yasa I.; Arda N.; Kirmizigul S.The apolar constituents of four Dianthus (Caryophyllaceae) species were determined by GC-MS. Palmitic, linoleic, and oleic acids were detected as dominant components in all species. D. elegans d'Urv. var. elegans had the highest antioxidant activity. All four species also showed considerable antimicrobial activity against S. epidermidis and C. albicans. © 2009 Springer Science+Business Media, Inc.Item Inhibitor activities of some seaweeds from the Aegean coast of Turkey(2011) Taşkin E.; Taşkin E.; Öztürk M.In this study methanolic extracts of four seaweeds belong to Phaeophyceae (Petalonia fascia, Stypocaulon scoparium) and Chlorophyceae (Cladophora prolifera, Codium fragile) that were collected from the Aegean coast of Turkey have been studied for their inhibitor activity against pathogenic microbes (Staphylococcus aureus, Staphylococcus epidermidis, Salmonella typhimurium, Enterobacter aerogenes, Escherichia coli, Enterococcus faecalis and Escherichia coli O157:H7), in vitro. Against the extracts of all the tested marine algae, S. aureus was the most sensitive bacteria since it was inhibited by most of the extracts. On the other hand, the highest inhibitor activity was shown to Enterobacter faecalis by the extract of Codium fragile. Whereas, the growth of Salmonella typhimurium and Enterobacter aerogenes were not inhibited by any of the extracts.Item Surface chemistry dependent toxicity of inorganic nanostructure glycoconjugates on bacterial cells and cancer cell lines(Editions de Sante, 2023) Sancak S.; Yazgan İ.; Bayarslan A.U.; Ayna A.; Evecen S.; Taşdelen Z.; Gümüş A.; Sönmez H.A.; Demir M.A.; Demir S.; Bakar F.; Dilek-Tepe H.; Kasemets K.; Otsus M.; Çeter T.Surface functionalized nanostructures have outstanding potential in biological applications owing to their target-specific design. In this study, we utilized laboratory synthesized carbohydrate-derivatives (i.e., galactose, mannose, lactose, and cellobiose derivatives) for aqueous one-pot synthesis of gold (Au) and silver (Ag) nanostructure glycoconjugates (NSs), and iron metal-organic framework glycoconjugates (FeMOFs). This work aims to test whether differences in the surface chemistry of the inorganic nanostructures play roles in revealing their toxicities towards bacterial cells and cancerous cell lines. As of the first step, biological activity of AuNSs, AgNSs, and FeMOFs were tested against a variety of gram (−) and gram (+) bacterial strains, where AgNSs possessed moderate to high antibacterial activities against all the tested bacterial strains, while AuNSs and FeMOFs showed their bacterial toxicity mostly depending on the strain. Minimum inhibitory concentration (MIC) and Minimum bactericidal concentration (MBC) determination studies were performed for the nanostructure glycoconjugates, for which μg/mL MBC values were obtained such as (Cellobiose p-aminobenzoic acid_AgNS) CBpAB_AgNS gave 50 μg/mL MBC value for P.aeruginosa and S.kentucy. The activity of selected sugar ligands and corresponding glycoconjugates were further tested on MDA-MB-231 breast cancer and A549 lung cancer cell lines, where selective anticancer activity was observed depending on the surface chemistry as well. Besides, D-penicillamine was introduced to galectin specific sugar ligand coated AuNS glycoconjugates, which showed very strong anticancer activities even at low doses. Overall, the importance of this work is that the surface chemistry of the inorganic nanostructures can be critical to reveal their toxicity towards bacterial cells and cancerous cell lines. © 2022 Elsevier B.V.