Browsing by Subject "Wechsler Memory Scale"

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    Neurocognitive evaluation in children with occipital lobe epilepsy
    (2012) Polat M.; Gokben S.; Tosun A.; Serdaroglu G.; Tekgul H.
    Purpose: This study aimed to explore cognitive functions in patients with childhood epilepsy with occipital paroxysms (CEOP) and to compare the performance of these patients with that of patients with symptomatic occipital epilepsy (SOE) and healthy control subjects. Method: Twenty-eight patients with epilepsy (17 CEOP, 11 SOE) were enrolled. The control group had similar demographical characteristics. Cognitive functions evaluated with Wechsler Intelligence Scale for Children-revised edition (WISC-R), The Visual Aural Digit Span (VADS) and Bender Visual Motor Gestalt Test (BVMG). Results: The WISC-R showed lower performance IQ with WISC-R in patients with occipital epilepsy than in healthy controls. The VADS test only showed lower scores in children with symptomatic occipital epilepsy. Mean BVMG test scores were significantly abnormal in both subgroups of childhood epilepsy with occipital paroxysms (early-onset CEOP/late-onset CEOP) and the group with SOE. Conclusion: Patients with CEOP, especially the late-onset form, have significant problems in the domains of visuomotor coordination, memory and attention. The academic performance of these patients should be monitored carefully in follow-up and appropriate educational support should be given as necessary. © 2012 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
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    Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: An individual patient data meta-analysis
    (2013) Bourne C.; Aydemir O.; Balanzá-Martínez V.; Bora E.; Brissos S.; Cavanagh J.T.O.; Clark L.; Cubukcuoglu Z.; Dias V.V.; Dittmann S.; Ferrier I.N.; Fleck D.E.; Frangou S.; Gallagher P.; Jones L.; Kieseppä T.; Martínez-Aran A.; Melle I.; Moore P.B.; Mur M.; Pfennig A.; Raust A.; Senturk V.; Simonsen C.; Smith D.J.; Bio D.S.; Soeiro-de-Souza M.G.; Stoddart S.D.R.; Sundet K.; Szöke A.; Thompson J.M.; Torrent C.; Zalla T.; Craddock N.; Andreassen O.A.; Leboyer M.; Vieta E.; Bauer M.; Worhunsky P.D.; Tzagarakis C.; Rogers R.D.; Geddes J.R.; Goodwin G.M.
    Objective: An association between bipolar disorder and cognitive impairment has repeatedly been described, even for euthymic patients. Findings are inconsistent both across primary studies and previous meta-analyses. This study reanalysed 31 primary data sets as a single large sample (N = 2876) to provide a more definitive view. Method: Individual patient and control data were obtained from original authors for 11 measures from four common neuropsychological tests: California or Rey Verbal Learning Task (VLT), Trail Making Test (TMT), Digit Span and/or Wisconsin Card Sorting Task. Results: Impairments were found for all 11 test-measures in the bipolar group after controlling for age, IQ and gender (Ps ≤ 0.001, E.S. = 0.26-0.63). Residual mood symptoms confound this result but cannot account for the effect sizes found. Impairments also seem unrelated to drug treatment. Some test-measures were weakly correlated with illness severity measures suggesting that some impairments may track illness progression. Conclusion: This reanalysis supports VLT, Digit Span and TMT as robust measures of cognitive impairments in bipolar disorder patients. The heterogeneity of some test results explains previous differences in meta-analyses. Better controlling for confounds suggests deficits may be smaller than previously reported but should be tracked longitudinally across illness progression and treatment. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.