Browsing by Subject "clobetasol propionate"

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    Topical calcineurin inhibitors, pimecrolimus and tacrolimus
    (2007) Ermertcan A.T.; Öztürkcan S.
    Pinecrolimus and tacrolimus represent the first members of a new class of medications, calcineurin inhibitors. These topical macrolide immunomodulators have been successfully introduced in the treatment of atopic dermatitis. They inhibit T cell proliferation, mast cell degranulation, production and release of IL-2, IL-4, IF-γ and TNF-αa. They do not effect endothelial cells and fibroblasts, so they do not induce skin atrophy. In several studies, it has been shown that topical pimecrolimus and tacrolimus are effective, well tolerated and safe in both adults and children with atopic dermatitis. Picmecrolimus permeates less through the skin than tacrolimus and much lessthan corticosteroids. It has a lower potential for transcutaneous absorption resulting in a lower risk of systemic effects. In addition, they have been used in other inflammatory skin diseases including psoriasis, lichen planus, seborrheic dermatitis, allergic contact dermatitis, vitiligo, pyoderma gangrenosum, alopecia areata, graft versus host disease, akne rosacea, etc. In this review article mechanism of action, efficacy, safety of pimecrolimus and tacrolimus, and future directions of these immunomodulators were discussed. © 2007 Bentham Science Publishers Ltd.
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    Amlodipine-induced generalized fixed drug eruption clinically mimicking mycosis fungoides
    (Blackwell Publishing Inc., 2021) Çetinarslan T.; Ermertcan A.T.; Temiz P.
    [No abstract available]
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    Efficacy of treatment with excimer phototherapy in nail dystrophy secondary to lichen striatus.
    (Dermatologia Pediatrica, 2023) Sezer E.; Kayahan S.
    Nail dystrophy secondary to lichen striatus is rare and difficult to treat. A 4-year-old girl with this problem, who has not responded to topical treatment with clobetasol propionate, is treated with excimer phototherapy which leads to rapid improvement. This treatment, which as far as we know has never been described in the literature, constitutes an effective and safe therapeutic option in cases that do not respond to other topical therapies. © 2023 Dermatologia Pediatrica. All rights reserved.