Browsing by Subject "cytokeratin 7"

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    Urachal urothelial carcinoma diagnosed at a radical prostatectomy operation: A case report
    (2010) Nese N.; Kesici G.; Lekili M.; Isisag A.
    BACKGROUND: Urachal carcinomas are rare tumors, and the majority of them are adenocarcinomas. Up to now, only 21 urachal urothelial carcinomas (UCas) have been reported. Here, we describe a case of high grade UCa arising from the urachal remnants. CASE: A 66-year-old man presented with voiding difficulties. Prostate specific antigen (PSA) was 5.46 ng/mL. Prostatic adenocarcinoma (PCa) (Gleason score 6) was diagnosed by needle biopsies. After the diagnosis of high grade, muscle invasive UCa with intact mucosa on frozen examination of the dome of bladder wall during the radical prostatectomy operation (RPO), partial cystectomy was performed. Microscopically, among the tumoral islands, cystic structures lined by cells with a benign appearance, which are considered urachal remnants, were noted. Cytokeratin 7 and high-molecular-weight cytokeratin were strongly positive, PSA and carcinoembryonic antigen were negative. Radiotherapy was given for both UCa and PCa. Six months after the diagnosis, an undifferentiated tumor was detected in a bladder transurethral resection specimen; thus, chemotherapy was given. After 1 course of chemotherapy, the patient was doing well. CONCLUSION: The origin of urachal carcinomas is usually obscured as it is a highly invasive carcinoma. The patient presented here was diagnosed incidentally during RPO. Although the stage was advanced, the tumor was detected before urachal remnants were destroyed. The treatment choice for urachal carcinomas is cystectomy. Adjuvant chemotherapy and radiotherapy are controversial. © Science Printers and Publishers, Inc.
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    Gastric carcinoma demonstrating rhabdoid features
    (2010) Karadeniz T.; Ayhan S.; Turna A.; Tireli M.
    Rhabdoid tumor, first described as an aggressive kidney tumor in infants and children and also observed less commonly in extra-renal locations, is seen very exceptionally in the gastrointestinal system. Gastrointestinal tumors with rhabdoid features are also extremely rare. A 59-year-old man with a long history of nausea, vomiting and weakness had been diagnosed as "diffuse-type gastric carcinoma" by the evaluation of endoscopic biopsy specimen at an other hospital. The total gastrectomy specimen showed an ulcerated mass measuring 7x4x4 cm located at the lesser curvature. The tumor penetrated the entire gastric wall and invaded the perigastric fat. The histopathological and immunohistochemical evaluation revealed a gastric carcinoma with rhabdoid features. The tumor was presented to emphasize the importance of clinical, morphological and immunohistochemical differential diagnosis from diffuse type gastric carcinoma as it has a very poor prognosis and is rarely seen in the gastrointestinal system.
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    Primary squamous cell carcinoma of the breast: A case report and immunohistochemical features for differential diagnosis; [Memenin primer skuamöz hücreli karsinomu: Olgu sunumu ve Ayırıcı tanı açı;sından İmmunohistokimyasal özellikleri]
    (Ekin Tibbi Yayincilik, 2010) Temiz P.; Kandiloǧlu A.R.; Şimşek G.; Coşkun T.; Göktan C.
    We present a 68-year-old postmenopausal woman with a rapidly growing right breast mass. It was diagnosed as "invasive ductal carcinoma" on tru-cut biopsy owing to infiltrative pattern and c-erbB-2 (HER2/neu) and progesterone receptor positivities. Partial response was obtained after four cure chemotherapy (adriamycin and cyclophosphamide). Then, she underwent a modified radical mastectomy with axillary lymph node dissection (level III). Grossly, a white-tan, solid, ill-defined tumor with 5 cm diameter located in the upper inner and outer quadrant of the breast was detected. Central portion of the tumor showed necrotic and hemorrhagic changes. Microscopic examination revealed poorly differentiated squamous cell carcinoma (SCC) having intraductal epithelial hyperplasia with squamous cell metaplasia and multiple small tumor foci at the periphery. The tumor had patchy necrotic, hemorrhagic and fibrotic areas representing regressive changes due to chemotherapy effect. Immunohistochemically, the tumor stained diffusely with CK7, CK8, CK19, HMW-CK and E-cadherin, whereas focally with CEA. Estrogenand progesterone receptors and c-erbB-2 were negative in the tumor. Five out of 20 lymph nodes dissected from the specimen were metastatic. Clinically, other organs were ruled out as the originating site of the tumor. She had taken oral chemotherapy (capecitabine) after surgery and has been living healthy for one year. © Medical Journal of Trakya University.