Browsing by Subject "eosinophil cationic protein"

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    Correlation of quality of life with clinical parameters and eosinophilic cation protein levels in children with allergic rhinoconjunctivitis
    (2008) Yuksel H.; Yilmaz O.; Sogut A.; Ertan P.; Onur E.
    Background: Systemic and mucosal roles of eosinophils in the pathogenesis of allergic rhinoconjunctivitis (AR) are known. The aim of this study was to investigate the relationship of clinical parameters and quality of life with eosinophilic cationic protein (ECP) in grass pollen-sensitive children with seasonal AR. Methods: This study included 31 children with AR and 18 healthy controls aged between 5 and 15 years. ECP levels in nasal lavage fluid and serum were measured. AR symptom scores were calculated and the pediatric rhinoconjunctivitis quality of life questionnaire (PRQLQ) was filled in for all patients. Results: Mean serum and nasal ECP levels (ng/ml) were significantly higher in the patient group (p < 0.05 for both). In the AR group, the mean clinical symptom score was 7.3 ± 2.2, while the total PRQLQ score, activity limitation, symptoms and emotional function domains were 2.5 ± 0.9, 3.0 ± 1.1, 2.5 ± 1.2 and 2.6 ± 1.1, respectively. The total clinical symptom score and disease duration showed a significant correlation with the total PRQLQ score (p = 0.00 and 0.003, respectively). However, neither nasal lavage nor serum ECP levels were significantly correlated with symptom score, duration of disease, PRQLQ total score or domains (p > 0.05 for all). Conclusion: These results may indicate the absence of a correlation between clinical status and quality of life and levels of ECP in tissues with allergic inflammation. Copyright © 2008 S. Karger AG.
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    Bronchiolitis in childhood: Updates on etiopathogenesis and immunologic lung injury; [Çocukluk çaǧinda bronşiyolitler: Etiopatojenez ve immünolojik akciǧer hasarindaki yenilikler]
    (Kare Publishing, 2010) Yüksel H.; Türkeli A.; Yilmaz Ö.; Güler S.
    Acute bronchiolitis is a disease characterized with bronchiolar inflammation due to viral infections in children younger than two years that is associated with wheezing, cough, tachypnea, retractions and prolonged expiration. Many pathogens, among which respiratory syncytial virus is the most common, play role in the etiology. Cellular damage due to viral pathogens and anatomic and immunological factors of the host play a role in the development of lower respiratory tract infections only in some children exposed to respiratory syncytial virus and other viruses. Viral infections in children may change Th1/Th2 immune response pattern. Severity of disease changes with the degree of inflammation due to the immune response. Moreover, an increase in disease severity may be observed due to the activation of the non-adrenergic non-cholinergic neurogenic system. Severe RSV infections may develop in children with genetic predisposition. We explained the role of environmental factors, genetic and structural susceptibility of the host, and contribution of immunologic response in this susceptibility, in addition to the role of responsible infectious agents, in the development and severe progression of bronchiolitis.