Browsing by Subject "eye injury"
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Item Ofloxacin levels after intravitreal injection. Effects of trauma and inflammation(1999) Öztürk F.; Kortunay S.; Kurt E.; Inan Ü.Ü.; Ilker S.S.; Basci N.E.; Bozkurt A.; Kayaalp S.O.Purpose: This study was carried out to get an insight into the ofloxacin elimination after intravitreal injection in rabbits. We also studied the effects of trauma and inflammation on the vitreous ofloxacin levels after intravitreal injection of ofloxacin. Methods: A penetrating eye injury in the right eye was inflicted on 24 rabbits and another 12 animals were used as control. A standardized intraocular inflammation was induced by intravitreal injection of a suspension of Staphylococcus aureus in half of the traumatized eyes. Ofloxacin (200 μg/0.1 ml) was injected into the midvitreous cavity of both traumatized and control right eyes, and samples were obtained at 2, 8, 24 and 48 h after injection. Drug concentrations were measured using high-pressure liquid chromatography analysis. Results: Vitreous levels of ofloxacin were above the MIC90 at 2 and 8 h in all groups for most of the common microorganisms causing endophthalmitis and also at 24 h in traumatized-infected eyes. At the second hour, the mean vitreous concentrations of ofloxacin both in traumatized and traumatized-infected eyes were lower than that in the control eyes (p < 0.05). At 8 h, the mean vitreous concentrations of ofloxacin in the traumatized and in the traumatized-infected eyes were higher than that in the control eyes (p < 0.05). At 24 h, the mean ofloxacin concentration was higher in the traumatized-infected eyes than that in control (p < 0.01) and traumatized eyes (p < 0.05), and also higher in the traumatized eyes than that in the control eyes (p < 0.05). The mean ofloxacin concentrations in the traumatized and traumatized-infected eyes were significantly higher (p < 0.01) than those in the controls at 48 h. The elimination half-life of ofloxacin in the control eyes was 5.65 h and trauma and inflammation prolonged the half-life to 9.47 and 9.72 h, respectively. Conclusion: Clearance of ofloxacin is fast and appears to be reduced by trauma and inflammation. Therapeutic drug levels in traumatized-infected eyes were maintained up to 24 h. This may be an important pharmacokinetic advantage in treating endophthalmitis unless the dose used has local toxicity and allows a longer dose interval when the dose is repeated.Item Effects of trauma and infection on ciprofloxacin levels in the vitreous cavity(Lippincott Williams and Wilkins, 1999) Öztürk F.; Kortunay S.; Kurt E.; Ilker S.S.; Inan U.U.; Basci N.E.; Bozkurt A.; Kayaalp S.O.Objective: This study was designed to determine the effects of trauma and infection on vitreous ciprofloxacin levels after intravitreal injection of ciprofloxacin in rabbits. Methods: A penetrating injury was made in the right eyes of 24 rabbits. In the eyes of half of the traumatized animals, a standardized intraocular infection was induced by intravitreal injection of a suspension of Staphylococcus aureus. The intact left eyes of the traumatized group were maintained as controls. Ciprofloxacin (200 μg/0.1 mL) was injected into the midvitreous cavity of both eyes in all animals and samples were obtained at 2, 8, 24, and 48 hours after injection. Drug concentrations were measured using high-pressure liquid chromatography analysis. Results: At the second hour, the mean vitreous concentration of ciprofloxacin in the traumatized eyes was lower than that in control eyes (P < 0.05). The mean ciprofloxacin concentrations were significantly higher (P < 0.05) in the traumatized-infected eyes than were those in control or traumatized eyes at 24 and 48 hours. The elimination half-life of ciprofloxacin in control and traumatized eyes was 6.02 hours and 5.02 hours, respectively, and infection prolonged the half-life to 15.06 hours. Vitreous levels of ciprofloxacin were above the minimum inhibitory concentration (MIC90) for most of the common microorganisms causing endophthalmitis in all groups at 2 and 8 hours, but also at 24 and 48 hours in traumatized-infected eyes. Conclusion: Infection appears to decrease the clearance of ciprofloxacin. Therapeutic drug levels in traumatized-infected eyes were maintained up to 48 hours. Assuming that the animal model used may have a predictive value for the drug elimination in traumatized-infected human eyes, we suggest that local administration of ciprofloxacin every 2 days may be relevant from the therapeutic perspective.Item The effect of long-term use and inflammation on the ocular penetration of topical ofloxacin(Swets en Zeitlinger B.V., 1999) Öztürk F.; Kortunay S.; Kurt E.; Inan Ü.Ü.; Ilker S.S.; Basci N.; Bozkurt A.Purpose. To study the penetration of ofloxacin into the aqueous and vitreous humors after long-term topical administration and to investigate the effects of inflammation on drug penetration in rabbits. Methods. A standardized model of intraocular infection after penetrating injury was achieved in the right eyes of 16 rabbits. The animals were randomly and equally divided into two groups. The intact left eyes of the groups were maintained as the control. Ofloxacin eyedrops (0.3) were instilled into all eyes at a frequency of 2 drops every hour for 7 hours in the first group and for 14 hours in the second group. Half an hour after the last drop, samples of the aqueous and vitreous humors were taken and ofloxacin concentrations were measured by using HPLC. Results. The mean aqueous humor concentrations of ofloxacin in control eyes after 7 and 14 hours of instillation were: 1.45 ± 0.93 μg/ml and 2.48 ± 0.33 μg/ml, respectively; those in infected eyes 2.35 ± 1.84 μg/ml and 3.49 ± 1.47 μg/ml, respectively. However the differences among the groups were not significant (p > 0.05). The vitreous ofloxacin concentrations in the control eyes were similar after 7 and 14 hours of instillation (0.23 ± 0.14 μg/ml, 0.27 ± 0.10 μg/ml, respectively). In infected eyes, the mean vitreous ofloxacin concentration after 14 hour of instillation was significantly higher than that in control eyes (p < 0.05; 0.4 ± 0.09 μg/ml, 0.29 ± 0.11 μg/ml, respectively). The mean vitreous ofloxacin concentration in infected eyes after 14 hours instillation was not significantly higher than that after 7 hours instillation. Conclusions. Topical ofloxacin instillation for 7 or 14 hours yields aqueous concentrations above the MIC90 for common ocular pathogens. Prolonged application and the presence of inflammation increased the penetration of ofloxacin into the vitreous humor.Item Ocular findings in a measles epidemic among young adults(Swets en Zeitlinger B.V., 2000) Kayikçioǧlu Ö.; Kir E.; Söyler M.; Güler C.; Irkeç M.Purpose: To present ocular findings in a measles epidemic outbreak among young adults. Methods: Ophthalmic lesions in an unselected group of 61 young military personnel with measles were followed. Eighteen of the patients had symmetric keratitis in both eyes. They were treated with diclofenac sodium eyedrops qid in the right eye, while the left eye was observed untreated. The disappearance of the corneal lesions in both eyes was compared. Results: Forty patients (65.6%) had measles conjunctivitis with bulbar and tarsal conjunctival hyperemia. Five (8.2%) had increased mucous secretion. Thirty-five (57.4%) had superficial punctate conceal epithelial and subepithelial lesions which stained with fluorescein. Ten patients had corneal lesions without evident conjunctival pathology. Fourteen patients had subconjunctival hemorrhages, it of whom had bilateral lesions mostly in the superonasal quadrant. The time to disappearance of corneal lesions was 4.5 ± 3.2 days in the diclophenac-treated right eyes, and 4.1 ± 3.8 days in the left eyes. We did not observe a significant difference in the healing time between the two eyes (P = 0.75) Conclusion: Measles did not cause major ocular complications in healthy patients. Keratitis was unresponsive to diclophenac sodium eyedrops with respect to healing time and end result.Item Clinical results in patients with combined penetrating keratoplasty and vitreoretinal surgery using landers wide-field temporary keratoprosthesis(Turkish Ophthalmology Society, 2019) Mayalı H.; Kayıkçıoğlu Ö.; Altınışık M.; Bıçak F.; Kurt E.Objectives: To evaluate the clinical results of combined pars plana vitrectomy (PPV) with Landers wide-field temporary keratoprosthesis and penetrating keratoplasty (PK). Materials and Methods: From January 2016, traumatic eyes with coexisting corneal and vitreoretinal diseases that underwent combined keratoprosthesis/PPV/PK surgery were retrospectively evaluated. Demographic characteristics, visual acuity (VA), intraocular pressure (IOP) and clinical findings of the cornea, lens, and retina were recorded during the follow-up. Cases with clear corneal graft, attached retina, normotonic IOP, and improved or stable VA were considered successful. Results: Eight eyes were enrolled in the study. The mean follow-up time was 21.1±8.20 months. Surgery was performed a mean of 23 (10-40) days after trauma. Preoperative VA ranged from no light perception to counting fingers from 50 cm. Postoperatively, corneal graft was clear in 5 patients (62.5%) and retina was attached in 6 eyes (75%). Chronic hypotonia developed in 3 patients (37.5%). VA was unchanged in 3 patients and improved in 5 patients. A total of 5 cases (50%) were considered successful. Shorter interval between trauma and surgery was associated with higher likelihood of success (p=0.043). No significant difference was observed between the groups in terms of type or location of trauma (p=1; p=0.143). Conclusion: Although the functional results are not very satisfactory, the combined procedure provides a final opportunity for preserving remaining vision and anatomic reconstruction in eyes that will otherwise result in phthisis due to severe anterior and posterior segment pathologies. © 2019 by Turkish Ophthalmological Association.Item Pars Plana Vitrectomy for Central Retinal Artery Occlusion Without Emboli(Gazi Eye Foundation, 2023) Kayıkcıoğlu Ö.R.; Doğruya S.; Altınbay B.T.; Altınışık M.; Kurt E.Purpose: The results of patients who had 23-G pars plana vitrectomy (PPV) unresponsive to medical therapy for central retinal artery occlusion without visible embolization are presented. Materials and Methods: We operated on eight patients who were treated for acute central retinal artery occlusion without visible emboli in our clinic. We started emergency medical treatment following diagnosis which was unsuccessfull. Afterwards, the patient had PPV in six cases and PPV- trabeculectomy in two cases. During the operation we applied intraoperative hypotonia for ten minutes and we tried to restore retinal circulation with fluid turbulance on optic nerve head. While visual acuity remained at the basal level in five patients (hand movement positive), slight increase was observed in three patients (preop P (-), 20 cmFC, 2 mFC,; postop 30 cmFC, 30 cmFC, 0.1 respectively). Discussion and Conclusion: Primary pars plana vitrectomy and surgical hypotonia may be an early treatment option for central retinal artery occlusion without visible emboli, which should be evaluated in large scale studies. © 2023 Gazi Eye Foundation. All rights reserved.