Browsing by Subject "glaucoma"
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Item Evaluation of intraocular pressure and cataract formation following the long-term use of nasal corticosteroids(Medquest Communications LLC, 1998) Öztürk F.; Yücetürk A.V.; Kurt E.; Ünlü H.H.; Ilker S.S.It is possible that corticosteroids administered via nasal spray might reach ocular structures in levels sufficient to provoke an ocular hypertensive response and cause posterior subcapsular cataracts (PSCs) in susceptible individuals. In the present study, 26 patients who had undergone endoscopic sinus surgery were evaluated prospectively with respect to intraocular pressure and PSC formation following the use of nasal steroids for at least three months. Eighteen patients (69%) self-administered 200 μg/day of budesonide nasal spray twice daily, and eight patients (31%) self- administered 200 μg/day of beclomethasone dipropionate nasal spray twice daily, for a period of three to 19 months (mean 8.8 ± 3.6 months). Ophthalmologic examination, tonometry, visual field testing and biomicroscopic studies revealed no evidence of ocular hypertension or PSCs during postoperative follow-up. We conclude that intranasal corticosteroids can be used safely for prolonged periods without increasing the risk of ocular hypertension or PSCs.Item Ophthalmic findings in GAPO syndrome(1999) Ilker S.S.; Öztürk F.; Kurt E.; Temel M.; Gül D.; Sayli B.S.Background: The main manifestations of GAPO syndrome are growth retardation (G), alopecia (A), pseudoanodontia (P), and optic atrophy (O). Cases: This syndrome has been described in 21 patients from 16 different families. Four cases are from Turkey and have been presented by Sayli and Gul. The purpose of our study is to document the cases from Turkey and discuss the ophthalmological and neuro-ophthalmolgical findings of these and other reported GAPO cases. Observations: All patients in the literature and our 4 cases have severe growth retardation with delayed bone age in infancy, characteristic facial appearance (high and bossed forehead, midface hypoplasia), alopecia or severe hypotrichosis, and pseudoanodontia. Optic atrophy was present in 1 of our cases and in 5 previous cases. Glaucoma was present in 5 cases, including 2 of ours. Buphthalmia and keratopathy secondary to glaucoma were also observed. White eyelashes, seen only in our cases, may be a sign of 'early senility.' Conclusions: Optic atrophy is not a constant finding in GAPO syndrome. Glaucoma may accompany the ocular findings. This syndrome has been attributed to either ectodermal dysplasia or the accumulation of extracellular connective tissue matrix, due to an enzyme deficiency involved in its metabolism. Current studies show that an elastin defect and secondary changes in collagen may be important in the pathogenesis of the disease.Item Cross-validation of the Turkish version of the 25-item National Eye Institute Visual Functioning Questionnaire (NEI-VFQ 25)(2005) Toprak A.B.; Eser E.; Guler C.; Baser F.E.; Mayali H.Purpose: To test the validity and reliability of the Turkish version of the self-administered form of the National Eye Institute Visual Functioning Questionnaire (NEI-VFQ 25). Methods: Patients with no limitations to respond to a health status interview and affected by a chronic eye disease were enrolled. The Turkish versions of the abbreviated form of World Health Organization Quality of Life (WHOQOL-BREF) and the NEI-VFQ 25 instruments were administered to all participants. Results: The mean (SD) age of the participants was 60.9 (14.5) years. There were 61 patients with one of the following conditions: Cataract (57.4%), diabetic retinopathy (13.2%), age related macular degeneration (ARMD) (11.4%), glaucoma (9.8%) and degenerative myopia (8.2%). The Cronbach alpha of the overall scale was 0.97; the Cronbach alpha ranged from 0.94 to 0.78 for the subscales. The physical, psychological, environmental and social domains of the WHOQOL-BREF had fair to good correlations with the NEI-VFO 25 (r = 0.68 to r = 0.26), which indicated a sufficient convergent validity. Patients with lower visual acuity (VA) had lower index scores than those with higher VA (p = 0.001), which showed a sufficient responsiveness. Conclusion: Statistical analysis showed that Turkish version of the NEI-VFQ is a valid and reliable instrument to measure vision-related quality of life in patients with chronic eye diseases. Copyright © Taylor & Francis Inc.Item Effects of latanoprost and betaxolol on cardiovascular and respiratory status of newly diagnosed glaucoma patients(2006) Erkin E.F.; Çelik P.; Kayikçioǧlu Ö.; Deveci H.M.; Şakar A.Aims: To investigate the cardiovascular and respiratory effects of topical latanoprost 0.005% and topical betaxolol 0.25% monotherapy in newly diagnosed glaucoma patients. Methods: Forty newly diagnosed glaucoma patients were enrolled in this prospective, observer-masked, randomized, parallel study. Patients received either latanoprost 0.005% or betaxolol 0.25% for a duration of 3 months. Baseline evaluation included intraocular pressure (IOP) measurement and cardiorespiratory examinations including pulse rate, systolic and diastolic blood pressure measurements and spirometry. These measurements were repeated after 3 months. Results: Both latanoprost and betaxolol reduced IOP significantly (p = 0.001). After 3 months of therapy, the mean pulse rate, systolic and diastolic blood pressure values of the betaxolol group were reduced (p = 0.027, p = 0.07 and p = 0.016, respectively). No significant changes occurred in the cardiovascular measurements of the latanoprost group (p > 0.05). There were no significant changes in any of the spirometric measurements tested for both groups (p > 0.05). Conclusion: Both latanoprost and betaxolol are safe concerning respiratory functions. Betaxolol may cause small changes in the cardiovascular system, suggesting that blood pressure and pulse rates should be checked before and in regular intervals after prescribing it for the elderly. Latanoprost seems to be a safe medication in view of absence of systemic cardiovascular and respiratory side effects. Copyright © 2006 S. Karger AG.Item Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA2LEN and AllerGen)(Blackwell Publishing Ltd, 2008) Bousquet J.; Khaltaev N.; Cruz A.A.; Denburg J.; Fokkens W.J.; Togias A.; Zuberbier T.; Baena-Cagnani C.E.; Canonica G.W.; Van Weel C.; Agache I.; Aït-Khaled N.; Bachert C.; Blaiss M.S.; Bonini S.; Boulet L.-P.; Bousquet P.-J.; Camargos P.; Carlsen K.-H.; Chen Y.; Custovic A.; Dahl R.; Demoly P.; Douagui H.; Durham S.R.; Van Wijk R.G.; Kalayci O.; Kaliner M.A.; Kim Y.-Y.; Kowalski M.L.; Kuna P.; Le L.T.T.; Lemiere C.; Li J.; Lockey R.F.; Mavale-Manuel S.; Meltzer E.O.; Mohammad Y.; Mullol J.; Naclerio R.; O'Hehir R.E.; Ohta K.; Ouedraogo S.; Palkonen S.; Papadopoulos N.; Passalacqua G.; Pawankar R.; Popov T.A.; Rabe K.F.; Rosado-Pinto J.; Scadding G.K.; Simons F.E.R.; Toskala E.; Valovirta E.; Van Cauwenberge P.; Wang D.-Y.; Wickman M.; Yawn B.P.; Yorgancioglu A.; Yusuf O.M.; Zar H.; Annesi-Maesano I.; Bateman E.D.; Kheder A.B.; Boakye D.A.; Bouchard J.; Burney P.; Busse W.W.; Chan-Yeung M.; Chavannes N.H.; Chuchalin A.; Dolen W.K.; Emuzyte R.; Grouse L.; Humbert M.; Jackson C.; Johnston S.L.; Keith P.K.; Kemp J.P.; Klossek J.-M.; Larenas-Linnemann D.; Lipworth B.; Malo J.-L.; Marshall G.D.; Naspitz C.; Nekam K.; Niggemann B.; Nizankowska-Mogilnicka E.; Okamoto Y.; Orru M.P.; Potter P.; Price D.; Stoloff S.W.; Vandenplas O.; Viegi G.; Williams D.[No abstract available]Item Management of pseudophakic malignant glaucoma and ultrasound biomicroscopic features(Elsevier B.V., 2009) Seymenoglu R.G.; Baser E.F.[No abstract available]Item Selective laser trabeculoplasty for the treatment of intraocular pressure elevation after intravitreal triamcinolone injection(Elsevier B.V., 2009) Baser E.; Seymenoglu R.[No abstract available]Item Trabeculectomy for advanced glaucoma.(2011) Baser E.F.; Seymenoglu G.; Mayali H.The objective of this study is to evaluate the visual prognosis and postoperative course in advanced glaucoma patients who underwent trabeculectomy. The records of 30 patients with advanced visual field (VF) defects undergoing trabeculectomy were retrospectively reviewed. Severe VF defects were defined as those with a sensitivity of ≤5 dB either in more than 85% of test points, excluding the central four points, or in >75% of test points, including three of the central four points with threshold automated perimetry. Main outcome measures were intraocular pressure (IOP), corrected visual acuity (VA) and mean deviation (MD) of VF tests. Mean preoperative IOP, VA and MD values were compared with their respective postoperative values. The latest examination of each patient was used to determine postoperative outcome measures. In addition, any complications encountered were recorded. A total of 34 trabeculectomies were performed. The mean age was 59.3 years (13-80 years). The mean follow-up time was 41.1 months (3-120 months). Preoperatively the mean IOP was 28.4 ± 13.1 mmHg, and the mean postoperative IOP was 14.8 ± 5.0 mmHg (P = 0.001). Preoperatively the mean VA was 0.87 ± 80, and the mean value of the MD was -24.5 ± 6.7 dB. At the latest follow-up there was no significant difference in VA (0.89 ± 79, P = 0.699) and MD (-23.9 ± 6.7, P = 0.244) values. Transient hypotony occured in five eyes while one eye with mitomycin C trabeculectomy experienced extended hypotony. Ten eyes showed reduction of VA between 1 and 5 lines due to cataracts and five eyes had late bleb failure with uncontrolled IOP. One patient had late endophthalmitis and one patient presented with blebitis, both of which were successfully treated. No patients experienced wipe-out phenomenon. In conclusion, our study of advanced glaucoma patients undergoing trabeculectomy, vision was preserved with no cases of unexplained loss of central vision. IOP was largely controllable, with cataract being the leading factor decreasing VA at late term.Item Congenital iris ectropion associated with juvenile glaucoma(2011) Seymenoǧlu G.; Başer E.Congenital iris ectropion is an uncommon malformation of the anterior segment of the eye. The authors describe a case of bilateral congenital iris ectropion associated with juvenile glaucoma in an otherwise healthy 9-year-old girl. Intra-ocular pressure (IOP) measured by Goldmann applanation tonometry was 40 mmHg in the right eye and 32 mmHg in the left eye. Despite maximum IOP lowering therapy, the desired IOP levels needed to prevent further progression of the glaucoma could not be achieved. Visual field testing and confocal scanning laser tomography showed glaucomatous neuropathy. Trabeculectomy with antimetabolites (mitomycin C 0.2 mg/ml) was performed in both eyes and IOP was normalized without IOP lowering medications during a follow-up of 4 years. The authors point out the importance of recognizing congenital iris ectropion early to prevent blindness in young patients and improve their prognosis. © 2010 Springer Science+Business Media B.V.Item Comparison of spectral-domain optical coherence tomography and heidelberg retina tomograph III optic nerve head parameters in glaucoma(2013) Seymenoǧlu G.; Başer E.; Öztürk B.Background: To evaluate the agreement between the optic nerve head (ONH) measurements obtained by spectral-domain optical coherence tomography/scanning laser ophthalmoscope (SD-OCT/SLO) and the Heidelberg retinal tomograph III (HRT-III), and to compare the ONH measurements of both devices in different glaucoma types. Methods: In a prospective study, 30 patients with primary open-angle glaucoma (POAG) and 30 patients with pseudoexfoliation glaucoma (PXG) were enrolled. All patients underwent SD-OCT/SLO and HRT-III evaluation of the ONH during the same visit. Agreement between measurements of SD-OCT/SLO and HRT-III were evaluated by determination of intraclass correlation coeficients. In addition, mean ONH measurements obtained with both devices were compared between POAG and PXG patient groups. Results: Mean SD-OCT/SLO measurements were greater than those of HRT-III, except for mean and maximum cup depth. Intraclass correlation coefficient values for disc area, rim area, cup area, cup/disc area ratio, mean cup depth and maximum cup depth were 0.367, 0.213, 0.632, 0.681, 0.775 and 0.661, respectively. No significant differences were found between ONH parameters of POAG and PXG patients as measured with both devices (p > 0.01). Conclusion: ONH measurements with SD-OCT/SLO and HRT-III did not show clinically acceptable agreement in glaucoma patients. This precludes interchangeable use of these measurements in clinical practice. PXG and POAG patient groups displayed similar ONH measurements with both devices. Copyright © 2012 S. Karger AG, Basel.Item Comparison of diagnostic accuracy of MRA and GPS algorithms using HR III device in glaucoma patients; [Glokom hastalari{dotless}nda hrt iii cihazi{dotless}nda mra ve gps algoritmalari{dotless}ni{dotless}n tani{dotless}sal deǧerlerinin karşi{dotless}laşti{dotless}ri{dotless}lmasi{dotless}](Turkish Ophthalmology Society, 2014) Oǧuz Ulusoy M.; Fatma Başer E.; Göktuǧ Seymenoǧlu R.; Özcan Kayikçioǧlu R.Objectives: The aim of this study is to evaluate the diagnostic accuracy of Moorfields regression analysis (MRA) and glaucoma probability score (GPS) and to measure the agreement between these two programs in classifying eyes as normal or abnormal. Materials and Methods: The study included 150 glaucoma patients followed in our glaucoma unit and 120 control subjects without glaucoma. All subjects underwent total ophthalmological examination, standard achromatic perimetry, and imaging of the optic nerve head with the Heidelberg Retina Tomograph II (HRT), using HRT III software, Version 3.0. The HRT parameters were compared between the two groups. The diagnostic accuracies of the two classifications were measured when the borderline was taken as either normal (highest specificity criteria) or abnormal (highest sensitivity criteria). The agreement between them was calculated using the kappa (κ) coefficient. Results: All HRT parameters except height variation contour in our study showed statistically differences between the control and glaucoma groups (p=0.000). The parameters with the highest area under curves were GPS global score (0.817), vertical cup/disc ratio (0.816), cup/disc area (0.808), and cup area (0.783). According to the highest specificity criteria, MRA had a sensitivity of 66% and specificity of 89.1% and GPS had a sensitivity of 62.7% and specificity of 81.6%. According to the highest sensitivity criteria, MRA had a sensitivity of 85.3% and specificity of 68.3% and GPS had a sensitivity of 90% and specificity of 60.8%. A moderate agreement of 65.9% (178 eyes) with a κ coefficient of 0.47 was found between MRA and GPS. Conclusion: In conclusion, GPS and MRA had a similar sensitivity, but the specificity of MRA was found to be higher than that of GPS. A moderate agreement was found between these analysis programs.Item Comparison of icare pro tonometry and icare one tonometry measurements in healthy eyes(Turkish Ophthalmology Society, 2019) Mayalı H.; Sarıgül Ç.; Kurt E.; Kayıkçıoğlu Ö.R.; İlker S.S.Objectives: To compare intraocular pressure (IOP) measurements obtained with the Icare Pro tonometer used in clinical practice and the Icare One self-tonometer. Materials and Methods: Fifty-two eyes of 52 healthy, right-handed individuals with no prior intraocular surgery or ocular trauma, structural ocular pathology, or systemic disease were evaluated. IOP was first measured using the Icare Pro tonometer. The participants were then told how to use the Icare One tonometer and asked to measure their own IOP. The results were analyzed statistically using SPSS v.24. Results: Of the 52 healthy participants, 16 (30.7%) were male and 36 (69.3%) were female. Their mean age was 31.6±6.3 (23-47) years. Mean IOP measured with the Icare Pro was 17.10±6.2 (11.5-25.2) mmHg, and the mean self-measured IOP with Icare One was 14.01±3.4 (7-24) mmHg. When the two methods were compared using Levene’s t-test, there was a significant mean difference of -3.08±0.6 (95% confidence interval: -4.39 -1.78; p<0.001). Conclusion: In this study, there was a significant difference between the IOP measurements we made using the Icare Pro and the participants’ self-measured IOP using the Icare One, with the latter being relatively lower. This may be related to the fact that the participants were unfamiliar with using the Icare One. Although the Icare One is a promising tool for glaucoma patients to self-monitor their IOP, further studies are needed. © 2019 by Turkish Ophthalmological Association.Item Evaluation of the effect of body position on intraocular pressure measured with rebound tonometer(Turkish Ophthalmology Society, 2019) Mayalı H.; Tekin B.; Kayıkçıoğlu Ö.R.; Kurt E.; İlker S.S.Objectives: It is important to determine variables that influence intraocular pressure (IOP) measurement. This study aimed to evaluate the effect of body position on IOP. Materials and Methods: The study included 52 right eyes of 52 patients who presented to the ophthalmology department of our hospital and had no ocular disease except refractive errors. IOP was measured with an Icare PRO tonometer while patients were in sitting, standing, and supine positions, with intervals of 10 minutes between the positions. Correlations between the results were evaluated using Spearman’s correlation analysis and Wilcoxon tests. Results: Thirty-six of the 52 patients were female, 16 were male. Mean age was 31.65±6.30 (23-47) years. Mean IOP values in the sitting, standing, and lying positions were 17.76±3.41 (12.70-25.60) mmHg, 17.10±3.27 (11.50-25.20) mmHg, and 18.46±4.67 (10.50-29.40) mmHg, respectively. There were no statistically significant differences between measurements taken in the different positions (p=0.112, p=0.472, p=0.071). We observed that there was no relationship between age and body position (p>0.45, p>0.79, p>0.77) or between gender and position (p>0.59, p>0.69, p>0.54). Conclusion: Gender and age had no effect on IOP measured in different body positions. There were also no significant differences between IOP values measured in the different positions. Therefore, we believe the portable Icare PRO tonometer can be used for patients who are confined to bed and will provide IOP measurements that are concordant with values obtained while sitting. © 2019 by Turkish Ophthalmological Association.Item Changes in optic nerve head and macula optical coherence tomography angiography parameters before and after trabeculectomy(Springer Japan, 2022) Güngör D.; Kayıkçıoğlu Ö.R.; Altınışık M.; Doğruya S.Purpose: To evaluate the effects of lowering intraocular pressure (IOP) on foveal avascular zone (FAZ), peripapillary and macular vessel density (VD) by optical coherence tomography angiography (OCTA) in patients with open angle glaucoma after trabeculectomy. Study design: Prospective study Methods: Twenty eyes of 20 patients with primary open angle glaucoma (POAG) or exfoliation glaucoma (EG) who were followed up to six months and underwent trabeculectomy were included in our study. OCTA, AngioVue (Optovue Inc.) software was used to analyse the FAZ, peripapillary VD, macular superficial capillary plexus (SCP) and deep capillary plexus (DCP) VD. The parameters of the preoperative and postoperative controls were compared statistically. Results: Twelve of the patients (60%) had POAG and eight (40%) had EG. Mean IOP measured was 22.4±2.4 mmHg preoperatively and 14.9±2.4 mmHg in the postoperative sixth month (p <0.001). There were no significant changes in OCTA optic disc and macular SCP VD values at the end of the sixth month. In macular DCP parameters; whole image VD (WI-VD), foveal VD (F-VD), parafoveal VD (PAF-VD) and perifoveal VD (PEF-VD) values increased statistically (p=0.003; p=0.026; p=0.006; p=0.004). There was a statistically significant decrease in FAZ area (FAZ-A) and FAZ perimeter (FAZ-P); and a significant increase was found in foveal density values (FD) (p=0.026; p=0.049; p=0.005). Conclusions: We found that reducing IOP by trabeculectomy did not affect the microcirculation of the peripapillary region and macular SCP, while there was a significant increase in the DCP parameters of the macular region. © 2022, Japanese Ophthalmological Society.Item Pars Plana Vitrectomy for Central Retinal Artery Occlusion Without Emboli(Gazi Eye Foundation, 2023) Kayıkcıoğlu Ö.R.; Doğruya S.; Altınbay B.T.; Altınışık M.; Kurt E.Purpose: The results of patients who had 23-G pars plana vitrectomy (PPV) unresponsive to medical therapy for central retinal artery occlusion without visible embolization are presented. Materials and Methods: We operated on eight patients who were treated for acute central retinal artery occlusion without visible emboli in our clinic. We started emergency medical treatment following diagnosis which was unsuccessfull. Afterwards, the patient had PPV in six cases and PPV- trabeculectomy in two cases. During the operation we applied intraoperative hypotonia for ten minutes and we tried to restore retinal circulation with fluid turbulance on optic nerve head. While visual acuity remained at the basal level in five patients (hand movement positive), slight increase was observed in three patients (preop P (-), 20 cmFC, 2 mFC,; postop 30 cmFC, 30 cmFC, 0.1 respectively). Discussion and Conclusion: Primary pars plana vitrectomy and surgical hypotonia may be an early treatment option for central retinal artery occlusion without visible emboli, which should be evaluated in large scale studies. © 2023 Gazi Eye Foundation. All rights reserved.