Browsing by Subject "hypoplasia"

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    Congenital midline cervical cleft: A rare embryo pathogenic disorder
    (2002) Genç A.; Taneli C.; Arslan O.A.; Daǧlar Z.; Mir E.
    Congenital midline cervical cleft (CMCC) is a rare disorder of the ventral neck. The cleft consists of an epithelium-covered, longitudinal central depression with a protuberance at the cervical end. The adjacent skin is tethered by scar tissue forming a depression, which ends in a blind sinus at the caudal end. Although a variety of embryological mechanisms are proposed, its etiology is obscure. Up to the present time, fewer than 50 cases have been reported in the English literature. CMCC can be seen in association with several midline anomalies related to the branchial arches, including median cleft of the lower lip and mandible, and hypoplasia or absence of other midline neck structures. We present a 36-day-old boy with CMCC to illustrate its clinical presentation and the result at 24 months postoperatively. © Springer-Verlag 2002.
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    Immunohistochemical staining of IGF-I, IGF-binding proteins-1 and -3, and transforming growth factor beta-3 in the umbilical cords of preeclamptic patients
    (2002) Inan S.; Vatansever S.; Kuscu N.K.; Laçin S.; Ozbilgin K.; Koyuncu F.
    Background. To detect the immunoreactivity of insulin-like growth factor-I, insulin-like growth factor-binding proteins-1 and -3 and transforming growth factor beta-3 in the umbilical cords of normal and preeclamptic patients. Methods. Umbilical cords were obtained from 15 normal and 15 preeclamptic patients. Immunoreactivities were determined using either indirect immunofluorescence or immunoperoxidase techniques on formalin-fixed, paraffin-embedded sections. Staining intensity was graded by a semiquantitative scoring method. The results were compared by Mann-Whitney U-test. Results. The umbilical cords were thinner and the vessels were hypoplastic in the preeclamptic group. Moderate staining intensity for insulin-like growth factor-I, insulin-like growth factor binding protein-1 and -3 and transforming growth factor-beta 3 was observed in normal patients. The preeclamptic group had mild and strong intensities for insulin-like growth factor-I and insulin-like growth factor binding protein-1, respectively, and intensity for insulin-like growth factor binding protein-3 did not change, but diffuse and increased intensity was observed for transforming growth factor-beta 3. Conclusion. Changes in the intensity of insulin-like growth factor-I and its major binding protein and the transformation of growth factor-beta 3 may play a role in the pathogenesis of preeclampsia by altering the structure and responsiveness of the umbilical cord.
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    Outcomes and management strategies in pregnancies with early onset oligohydramnios
    (S.O.G. CANADA Inc., 2015) Ulkumen B.A.; Pala H.G.; Baytur Y.B.; Koyuncu F.M.
    Objective: To evaluate the outcomes and management options in pregnancies with early onset oligohydramnios. Materials and Methods: The file datas of all pregnancies diagnosed as oligohydramnios or anhydramnios before 27 gestational weeks between January 2006 and September 2013 were evaluated retrospectively. The underlying pathology and associated anomalies, karyotype analysis, the outcome of the pregnancy (either termination or labour), and gestational week at the time of diagnosis were analyzed. Results: A total of 54 pregnancies were evaluated; mean gestational week at the time of the diagnosis was 19.8 ± 4.6. Mean maternal age was 27.28 ± 6.03. Thirty-seven pregnancies were anhydramniotic, 13 fetuses had associated anomalies, five of them had multicyctic dysplastic kidney, five had bilateral renal agenesis, one had hypoplastic right heart syndrome, one had clubfoot, and one had ventricular septal defect and cleft palate. Karyotyping was normal regarding the fetuses with structural anomalies. Nineteen patients had premature preterm rupture of membranes and 39 patients had termination of pregnancy. Conclusion: The prognosis of early onset oligohydramnios is poor. Main determinant is gestational week at the time of the diagnosis.