Browsing by Subject "sex difference"
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Item Psychiatric disorders in patients attending a dermatology outpatient clinic(1998) Aktan Ş.; Özmen E.; Şanli B.Background: Psychiatric comorbidity in patients with skin disorders has been reported. Objective: To find out the prevalence of psychiatric disorders in dermatology outpatients and to investigate the factors that affect the psychiatric symptoms. Methods: 256 patients attending our dermatology outpatient clinic completed a 12-item General Health Questionnaire (GHQ) following their dermatologic examination. A standardized personal interview was performed to establish a psychiatric diagnosis in patients sampled by using a stratified random sampling method. Results: The prevalence of psychiatric disorders was found to be 33.4% in the study group. The mean of the total GHQ scores of the sample group (n = 256 patients) was 3.656. The duration of the dermatologic complaints, sex of the subjects, localization of the lesions, and dermatologic diagnosis did not affect the total GHQ scores of the patients. Conclusion: Psychiatric comorbidity in 33.4% of the dermatology outpatients indicates the need for considering emotional factors for an effective management of the cutaneous disorders.Item Age and gender dependent alterations in the activities of glutathione related enzymes in healthy subjects(2001) Habif S.; Mutaf I.; Turgan N.; Onur E.; Duman C.; Özmen D.; Bayindir O.Objectives: Oxidative stress as a result of increased free radical production is implicated in the pathogenesis of several diseases. Specific antioxidant enzymes have a crucial role in the prevention of these deleterious effects. Since the activities of these enzymes differ significantly in different populations and seem to be affected by various environmental factors, in this study we aimed to determine the reference values of glutathione related antioxidant enzyme activities in the erythrocytes of healthy subjects and to investigate the possible variations as a function of age and gender in a healthy Turkish Mediterranean population. Design and methods: 130 healthy subjects (12-90 yr, 82 females, 48 males) were divided into six different age groups. Erythrocyte glutathione peroxidase (GSH-PX), glutathione reductase (GR) and glutathione-s-transferase (GST) activities were measured on a Hitachi 704 autoanalyser by the modification of previously described manual UV spectrophotometric methods. Results: No significant differences were observed in erythrocyte GSH-PX, GR and GST activities between different age groups. Overall, GST activities were significantly higher in females compared with males (8.08 ± 1.39, 6.88 ± 1.51 U/g Hb respectively, mean ± SD, p < 0.001). A significant positive correlation between GSH-PX and GR activities was observed (r = 0.49, p < 0.001). Conclusion: The results of this study suggested that the activities of GSH-PX, GR and GST did not depend. GST activities overall were higher in females. The reference values that we obtained were different than the previous reports. This situation implies that each population should determine its own reference values and should investigate the influence of environmental factors and life style habits on the activities of these enzymes that constitute a major part of the antioxidant defense system in the human organism. © 2002 The Canadian Society of Clinical Chemists. All rights reserved.Item Left ventricular aneurysm formation after anterior myocardial infarction: Clinical and angiographic determinants in 809 patients(2002) Tikiz H.; Atak R.; Balbay Y.; Genç Y.; Kütük E.Background: Previous studies have reported controversial results regarding the clinical and angiographic factors involved in the left ventricular aneurysm (LVA) formation after myocardial infarction (MI). Objective: This study was performed to determine the clinical and angiographic factors that are priori predictors of LVA following anterior myocardial infarction and so to provide a paradigm which may identify patients who were candidates for aneurysm formation. Methods: Of the patients who underwent coronary angiography during the interval between 1995 and 2000 in our clinic, 809 were found to have anterior MI and LVA (aneurysm group) (677 men, 132 women, mean age 53.3±11.4 years). The clinical and the angiographic data of these patients were compared with those of 446 patients (399 men, 47 women, mean age 55.2±10.5 years) with previous anterior MI and without LVA (control group). Results: LVA was found to occur more frequently in females (16.3% in women and 10.4%, in men, P=0.03) and in patients without previous angina (23.5 vs. 8.2%, P<0.0001). Major cardiovascular risk factors, previous anti-anginal medication and thrombolytic therapy did not show a significant difference between the two groups. Angiographic examination revealed that single-vessel disease, proximal left anterior descending artery (LAD) stenosis, total LAD occlusion, mean stenosis in LAD artery, end-diastolic pressure and left ventricular score were all higher in the aneurysm group compared to control group. After adjustment for other clinical and angiographic variables, single-vessel disease [odds ratio (OR) 5.89, 95% confidence interval (CI)=3.68-9.28, P<0.0001), absence of previous angina (OR=4.21, 95% CI=2.1-7.48, P=0.0003), total LAD occlusion (OR=2.63, 95% CI=1.97-3.53, P<0.0017) and female gender (OR=1.60, 95% CI=1.20-2.28, P=0.043) remained the independent determinants of LVA formation after anterior MI. Conclusion: In patients with LVA, logistic regression analysis revealed that (1) single-vessel disease, (2) absence of previous angina, (3) total LAD occlusion and (4) female gender were independent determinants in the formation of LVA after anterior MI. Coronary collateral status and risk factors, such as hypertension, diabetes mellitus, hypercholesterolemia, smoking and family history of CAD were not found to be important determinants in the aneurysm formation. © 2002 Elsevier Science Ireland Ltd. All rights reserved.Item Meckel's diverticulum: Incidence and complications in childhood; [Meckel divertikülü: Siklik ve çocukluk çaǧindaki komplikasyonlar](2003) Günşar C.; Ceylan H.; Munis N.; Karaca I.; Mir E.Aim: Meckel's diverticulum is the most commonly seen congenital anomaly of the gastrointestinal system. Many complications related with this diverticulum could be seen in childhood. The aim of this study is to investigate the incidence of Meckel's diverticulum in our population and to evaluate the features of the complications originating from it. Method: The data about 1685 patients who underwent laparotomy in İzmir Behcet Uz Children's Hospital between 1990-1996 were investigated. The patients with Meckel's diverticula were classified as symptomatic or asymptomatic. The parameters evaluated were age, sex, clinical presentation, associated anomalies, type of complications related with Meckel's diverticulum, ectopic mucosa, surgical treatment and complications. Results: 25 patients were classified as asymptomatic whereas 35 were classified as symptomatic in a group of 60 patients with Meckel's diverticulitis. The average age was 4.7 years. The incidence was calculated as 1.51 %. The male female ratio (m/f) was 2.5/l and 2.6/l for symptomatic and for asymptomatic patients respectively. Intestinal obstruction (18 cases) was the most common clinical finding presented with vomiting and abdominal pain which were the primary symptoms. Fifteen diverticulum in the asymptomatic group, and all of them in the symptomatic group were excised. The ratio of ectopic mucosa was found as 16 % for the asymptomatic, and 51 % for the symptomatic cases. Symptomatic group had a 16 % complication rate. Conclusion: Meckel's diverticulum is a congenital structure, which is frequently encountered with the clinical presentation of intestinal obstruction in childhood causing life-threatening complications it should be investigated in the laparotomies performed for acute abdomen and where appendices were found innocent.Item Intra-articular fractures of the tibial plafond. A comparison of the results using articulated and ring external fixators(2004) Okcu G.; Aktuglu K.We retrospectively reviewed 60 fractures of the tibial plafond treated by either an ankle-sparing diaphyseal-epiphyseal technique using the Ilizarov ring fixator or by an ankle-spanning technique using a monolateral articulated external fixator. The Ilizarov ring fixator was applied in 24 fractures and the monolateral articulated transarticular external fixator in 20. Both techniques were combined with limited open reduction and internal fixation of the articular surface if necessary. Between three and nine years after the injury, all patients returned for clinical and radiological assessment and evaluation of ankle function using the modified Mazur score. There were no significant differences between the two groups in terms of age, gender, mechanism of injury, type of fracture or length of follow-up. The mean functional ankle score was 86 points for the Ilizarov group and 82 points for the articulated fixator group. The difference was not significant (p = 0.07). There were no significant differences between the groups with regard to the radiographic score and late complications. Patients treated with the Ilizarov ring fixator had significantly better ankle and subtalar movement. We conclude that both techniques of external fixation are satisfactory methods of treatment for fractures of the tibial plafond, but that the total arc of movement of the joint is preserved better without bridging the ankle. © 2004 British Editorial Society of Bone and Joint Surgery.Item Some biological properties of mosquitofish populations (Gambusia affinis) living in inland waters of the Western Mediterranean Region of Turkey(2004) Öztürk Ş.; Ikiz R.Gambusia affinis, Baird & Girard, 1853, originally comes from North America and has been distributed all over the world for the biological control of mosquitoes. This study aimed to determine some biological properties, such as structure, age, growth and reproduction of the populations of G. affinis in Turkey. For this purpose, between November 1998 and October 1999, 2026 mosquitofish were caught in the wetlands of Fethiye-Akgöl, Dalaman and Ortaca in Muǧla province in the western Mediterranean region of Turkey and the data found were compared. In the Fethiye-Akgöl population the percentage of the 0+ age group was 97.59%, and of the 1+ age group was 2.41%; in the Dalaman population percentage of the 0+ age group was 99.71%, and of the 1+ age group was 0.29%; in the Ortaca population percentage of the 0+ age group was 94.37%, and of the 1+ age group was 5.63%. The mosquitofish population in Fethiye was 81.42% female and 18.58% male, in Dalaman 71.55% female and 28.45% male, and in Ortaca 70.42% female and 29.58% male. Total length (TL) in the Fethiye-Akgöl population was 1.3-5.5 cm. in Dalaman 1.7-5.5 cm and in Ortaca 1.3-5.8 cm; and total weight (W) in Fethiye-Akgöl was 0.02-2.31 g, in Dalaman 0.06-2.58 g and in Ortaca 0.02-5.83 g. In each population the gonadosomatic index (GSI) increased in March and April, had a slight decrease in May and increased again in mid May. At the beginning of January the GSI of the Fethiye population started to decrease again and the GSI decreased in Dalaman and Ortaca populations beginning in mid July. This shows that the mosquitofish is a bivoltine species. The average number of eggs belonging to each age group was 21.90 (0+) and 52.81 (1+) in Fethiye, 27.11 (0+) and 91.0 (1+) in Dalaman, and 28.24 (0+) and 81.78 (1+) in Ortaca. Average fecundity per gram was between 27.71 (0+) and 31.71 (1+) in Fethiye-Akgöl, between 42.97 (0+) and 39.99 (1+) in Dalaman, and between 35.28 (0+) and 37.39 (1+) in Ortaca.Item Basic life support skills of doctors in a hospital resuscitation team(2004) Tok D.; Tezcan Keleş G.; Taşyüz T.; Yentür E.A.; Toprak V.The aim of the present study was to evaluate the basic life support skills of doctors in a hospital resuscitation team and to identify potential factors affecting those skills. Twelve anesthesiology residents were induced in this study. Each doctor was asked to perform mouth-to-mouth ventilation for 10 minutes and then chest compression for another 10 minutes on a Laerdal Skillmeter Resusci-Anne manikin during the day (10 am) and at night (10 pm). The rates of correct ventilation, correct chest compression, ventilation errors (i.e., excessive inflation, stomach insufflation, insufficient ventilation), and compression errors (i.e., insufficient chest compression/decompression, excessive chest compression, incorrect hand placement) were determined for each 2-min interval up to 10 min. In addition, effects of sex, seniority, CPR duration, and time of day (day vs night) on those skills were assessed. The mean rates of correct ventilation were 53.3±23.9% (day) and 60.4±16% (night); the mean rates of correct chest compression, 76.9±15% (day) and 76.5±14.7% (night). During the first 2-minutes period of testing at night, men doctors more frequently achieved correct ventilation than did women doctors (p<0.05). Overall, the practical CPR skills of the study participants were not influenced by sex, seniority, CPR duration, or time of day; however, the participants' skills were poor. This suggests that all medical staff, especially members of in-hospital resuscitation teams, should undergo regular, periodic CPR training. © 2004 Tohoku University Medical Press.Item The effect of chronic antidepressant treatment on serum brain-derived neurotrophic factor levels in depressed patients: A preliminary study(Elsevier Inc., 2005) Aydemir O.; Deveci A.; Taneli F.Recent studies suggested a role of brain-derived neurotrophic factor (BDNF) in depression. While BDNF levels are lower in depressed patients, antidepressant treatment increases serum BDNF levels of depressed patients. Our study aims to test the effect of chronic venlafaxine treatment on serum BDNF levels in patients with a major depressive disorder. Ten patients diagnosed as major depressive disorder according to DSM-IV are included in the study. Two of the patients had their first episode and were drug-naive, the other eight patients were drug-free for at least 4 weeks. The severity of depression was assessed with Hamilton Depression Rating Scale (HDRS). The control group consisted of ten age- and sex-matched subjects without any psychiatric disorder. Blood samples were collected at the baseline and after 12 weeks of antidepressant treatment (during remission). At the baseline the mean serum BDNF level was 17.9±9.1 ng/ml and the mean HDRS score was 23.2±4.6. Serum BDNF levels of the study group were significantly lower than in the control group (31.6±8.6 ng/ml). At the end of the study, the mean serum BDNF level was 34.6±7.1 ng/ml whereas the mean HDRS score was 8.2±3.9. From the baseline to the remission after 12 weeks of treatment, the increase in serum BDNF level and the decrease in HDRS score were statistically significant, respectively. When we compared the serum BDNF level of depressed patients at remission to that of the controls, there was no statistically significant difference. This study shows that venlafaxine treatment of depression improves serum BDNF level which may be considered as a nonspecific peripheral marker of depression. © 2004 Elsevier Inc. All rights reserved.Item The effects of gender and menopause on serum lidocaine levels in smokers(Editions Medecine et Hygiene, 2005) Oztekin S.; Mavioglu O.; Elar Z.; Guven H.; Kalkan Ş.; Gurpinar T.It has been established that human cytochrome P450 (CYP) enzymatic activity is affected by gender, or by hormonal factors such as the menopause in women. Gender differences have a more pronounced effect on cytochrome (CYP) 3A4 isoenzyme activity, whereas cytochrome (CYP) 1A2 isoenzyme activity is mainly induced by chronic smoking. Lidocaine is frequently used in the treatment of hemodynamic changes following laryngoscopy and tracheal intubation during general anesthesia, and is metabolized by CYP3A4 and CYP1A2 isoenzymes in the liver. The aim of this study was investigate the effects of gender and menopause on serum lidocaine levels in smokers under general anesthesia. Six men, six premenopausal women and six postmenopausal women were enrolled in the study and received i.v. lidocaine (1 mg/kg) 1 minute before they underwent general anesthesia. Serum lidocaine concentrations were measured using the EMIT® method at 1, 5, 10, 20, 40 and 60 minutes post-administration. Statistical analyses were performed using the Mann-Whitney U-test. No statistically significant differences were found regarding the area under curve (AUC (0-60) μg/mL/min), elimination half-life (t1/2 [min]) of lidocaine and in the measured levels of serum lidocaine at any time point between the study groups (p>0.05). These results suggest that gender and menopause may have no significant effect on serum lidocaine levels in smokers.Item Drug-resistant pulmonary tuberculosis in western Turkey: Prevalence, clinical characteristics and treatment outcome(King Faisal Specialist Hospital and Research Centre, 2005) Surucuoglu S.; Ozkutuk N.; Celik P.; Gazi H.; Dinc G.; Kurutepe S.; Koroglu G.; Havlucu Y.; Tuncay G.Background: Although high antituberculosis (anti-TB) drug resistance rates have been reported in Turkey, the clinical characteristics and implications for the outcome of anti-TB treatment have not been fully investigated. We determined the prevalence of anti-TB drug resistance and examined demographic data, clinical characteristics and treatment outcome in relation to patterns of resistance. Methods: From the TB case registry of a university hospital and the two largest dispensaries in Manisa city, we identified all pulmonary TB cases with a culture-proven definitive diagnosis and antimicrobial susceptibility results for a 7-year period. We collected and analyzed demographic and clinical data and information on treatment outcome for those cases in relationship to anti-TB drug resistance. Results: Of 355 M. tuberculosis strains, 71.5% were susceptible to streptomycin, isoniazid, rifampicin and ethambutol. Any drug resistance and multi-drug resistance (MDR) rates were 21.1% and 7.3% and were higher in males (53% and 9%, respectively) than in females (22% and 1%, respectively). Drug resistance was significantly higher in old cases (acquired drug resistance) vs new cases (primary drug resistance), and was associated with treatment failure (P<0.001). The prevalence of MDR was significantly higher in the old cases (22.4%) than in the new cases (4.4%) (P<0.001). Symptoms, radiographic findings, associated diseases, and sputum smear positivity were unrelated to the development of resistance. The prevalence of any drug resistance and MDR was significantly higher in those with treatment failure than in patients with treatment success. Conclusion: High resistance rates, particularly for acquired MDR, indicate a need for improvement in the TB control programme in our region.Item The impact of co-morbid conditions on the SF-36: A primary-care-based study among hypertensives(Elsevier Inc., 2005) Aydemir O.; Ozdemir C.; Koroglu E.Background. Comorbidities in hypertension complicate the course causing more symptoms and deterioration in a patient's daily life. The aim of this present study is to describe the effect of comorbid conditions on health-related quality of life (HRQL) in hypertensive patients. Methods. The study was carried out in four different regions of Turkey by 156 general practitioners between October 1999 and April 2000. In addition to cardiological evaluation, SF-36 health survey questionnaire was used for quality of life measurement. Diagnosis of comorbid conditions were anamnesis based. Results. The mean age of the group (n = 938) was 58.1 ± 11.2, and 58.6% (n = 550) of the group was female. Total scores of the eight domains of SF-36 were lower than the normal population scores. Age and gender affected every domain of SF-36 scale negatively. Heart failure affected four of the domains, primarily physical domains. Previous transient ischemic attack was responsible for low HRQL in emotional role difficulties, vitality, and mental health, but previous stroke had an impact on physical functioning and emotional role. Previous myocardial infarction affected emotional role difficulties negatively whereas previous CABG surgery had a positive impact on the same domain. Obesity and angina pectoris affected physical functioning negatively, whereas peripheral arterial disease caused low general health perception. Nephropathy, retinopathy and diabetes had no impact on HRQL in hypertension. Conclusions. When the contribution of comorbid conditions is taken into consideration, it can be noticed that the impact of every other condition is similar to the same condition when it is pure. Hypertension per se seems to cause less impairment than expected in HRQL. © 2005 IMSS. Published by Elsevier Inc.Item Variations in sphenoid sinus anatomy with special emphasis on pneumatization and endoscopic anatomic distances(2005) Kayalioglu G.; Erturk M.; Varol T.Objectives: The purpose of this study was to present the morphometry and pneumatization of the sphenoid sinus in detail for the neurosurgeon for transnasal approach to the hypophyseal tumors and especially for functional endoscopic sinus surgery. Methods: One hundred and eighty midsagittal magnetic resonance images, 48 bones and 29 hemi-sectioned cadaveric heads obtained from Ege University, Faculty of Medicine, Departments of Anatomy and Radiology were used in 2003. The sphenoid sinuses were classified into sellar, pre-sellar, conchal and post-sellar types according to the extent of their posterior limits. Different measurements based on the surgical approach and sinus size were performed. Results: Conchal type sinus was observed in 1.9%, pre-sellar type 9%, sellar type 52.9% and post-sellar type 36.2% of the specimens. Conchal type sphenoid sinus was not observed in males, but in 1.7% of females. Pre-sellar type was observed in 5.6% of males and 2.8% of females. Sellar type was found in 24.4% of males and 23.9% females, and post-sellar type in 19.5% of males and 22.2% of females. The sphenoid sinus length at the upper and lower parts was 13.51±3.25mm and 24.57±6.65mm. The sphenoid sinus height at the anterior and posterior parts was 21.27±4.25mm and 14.5±4.07mm. Distance from the ostium to limen was 56.6±5.6mm and from ostium to sill was 64.6±6.11mm in cadaveric specimens. In MR images, distance from the ostium to the sill was 68.7±5.9mm and from sella to sill 82.8±6.2mm. Conclusion: Sphenoid sinus variations observed in pneumatization, size, localization and shape are important in providing a better surgical approach and avoiding surgical complications.Item Infant and adolescent deaths in Istanbul due to home accidents(2005) Aşirdizer M.; Yavuz M.S.; Albek E.; Cantürk G.Adolescent and infant deaths due to home accidents pose an important social problem and can be prevented significantly by appropriate measures. The aims of this study about adolescent deaths under the age of 18 and infant deaths due to home accidents were assessment of risk factors and proposals for protective measures. Toward these aims, 414 autopsy reports (Provided by Mortuary Section, Council of Forensic Medicine, Istanbul Turkey, 1996-2000) were reviewed, as well as scene investigation data and information from eyewitnesses. Determination of risk factors, appropriate education, as well as legal regulations for manufacturers of household articles may significantly reduce the number of infant and adolescent deaths due to home accidents.Item Comparative morphometry of the lower lumbar vertebrae: Osteometry in dry bones and computed tomography images of patients wtih and without low back pain(SAGE Publications Ltd, 2006) Varol T.; Iyem C.; Cezayirli E.; Erturk M.; Kayalioglu G.; Hayretdag C.Various factors affect the development of the vertebral canal. The dimensions of the vertebral canal and the intervertebral foramen can be altered by these factors before or after birth. Sex differences in dimensions have also been reported. When there is a stenosis of the vertebral canal or the intervertebral foramen, neural structures confined within them can be affected easily, resulting in symptoms. Using computed tomography images, we compared vertebral canal dimensions in 100 patients with low back pain and/or radiculopathy with those in 40 healthy, non-symptomatic controls. We also measured the dimensions of 275 dry bones. We found significant correlations among the variables in the live subjects. We found significant differences between patients and controls in the variables that were measured. Stenoses were more prevalent in females. Dry bone measurements showed some sex differences, and stenosis mainly in vertebrae L4, L5 and S1. Copyright © 2006 Cambridge Medical Publications.Item Increased serum leptin concentrations in patients with chronic stable angina pectoris and ST-elevated myocardial infarction(2006) Taneli F.; Yegane S.; Ulman C.; Tikiz H.; Bilge A.R.; Ari Z.; Uyanik B.S.Leptin is an adipocytokine that is produced mainly by adipose tissue; it is also identified in atherosclerotic lesions in human coronary atherosclerosis. However, the relation of serum leptin concentrations to ischemic heart disease (IHD) is still obscure. The aims of the present study were to investigate serum leptin concentrations in patients with ST-elevated myocardial infarction (STEMI) and with chronic stable angina pectoris (CSAP) and to evaluate the possible correlations of leptin to other atherosclerotic risk factors; including serum high sensitive C-reactive protein (Hs-CRP), serum homocysteine, and fibrinogen concentrations. For this purpose, 35 patients with CSAP, 40 with acute STEMI, and 30 control subjects with normal findings from coronary angiography were taken into the study prospectively. Serum leptin concentrations were significantly higher in patients with CSAP and STEMI compared to the control group (7.74 ± 1.34 vs 6.37 ± 1.85 ng/mL, p = 0.021 and 8.22 ± 3.13 vs 6.37 ± 1.85 ng/mL, p = 0.023, respectively). In addition, serum homocysteine concentrations were significantly increased in patients with CSAP (15.23 ± 5.96 vs 11.40 ± 2.11 μmol/L, p = 0.025) and patients with STEMI (15.90 ±5.02 vs 11.40 ±2.11 μmol/L, p = 0.012) compared to the control group. Serum fibrinogen concentrations were significantly increased only in the CSAP group as compared to controls (4.15 ± 1.39 vs 3.45 ± 1.19 g/L, p = 0.025). No significant correlation was found between leptin levels and selected risk factors. In conclusion, serum leptin concentrations were significantly higher in both the CSAP and STEMI groups. However, owing to the lack of correlation between the leptin levels and selected classical coronary risk factors, it may be considered that leptin can be evaluated as one of the independent risk factors for IHD. Further randomized and controlled studies will be required to determine the pathophysiological meaning of the increased leptin levels and the central role between adipocyte function and atherosclerosis. ©2006 Westminster Publications, Inc.Item The validity and reliability of the Turkish version of Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) in patients with mild and moderate Alzheimer's disease and normal subjects(2006) Mavioglu H.; Gedizlioglu M.; Akyel S.; Aslaner T.; Eser E.Objectives: The cognitive subscale of the Alzheimer's Disease Assesment Scale (ADAS-Cog) is the most widely used test clinical trials dealing with Alzheimer's disease (AD). The aim of this study was to investigate the validity and reliability of the Turkish version of ADAS-Cog. Methods: Twenty-nine patients with AD, fullfilling NINCDS-ADRDA criteria of probable AD, who were in stage 3-5 according to the Global Deterioration Scale (GDS), and 27 non-demented control subjects with similar age, gender and educational status were recruited for the study. The Turkish version of ADAS-Cog, Standardized Mini Mental Status Examination (MMSE) and Short Orientation-Memory-Concentration Test (SOMCT) were applied to both of the groups. Interrater reliability, internal consistency, test-retest reliability; face validity, differential validity and convergent validity were statistically analyzed. Results: Both MMSE and ADAS-Cog have significantly differentiated patients with AD and control subjects (p < 0.001). A significant correlation was established between MMSE and ADAS-Cog scores in AD group (r: -0.739). ADAS-Cog was also highly significantly correlated with GDS (r: 0.720) and SOMCT (r: 0.738). For the group with AD, control and whole cohort coefficients of internal consistency, Cronbach's α: 0.800, 0.515, 0.873 were found respectively. Inter-rater reliability for total ADAS-Cog score was found as ICC: 0.99 and 0.98 and test-retest reliability was found as ICC: 0.91 and 0.95 for demented and nondemented subjects, respectively. Conclusion: The Turkish version of ADAS-Cog has been found to be highly reliable and valid in differentiating patients with mild and moderate AD from nondemented subjects. Copyright © 2006 John Wiley & Sons, Ltd.Item Hypertension prevalence among elderly people: A sample from Manisa; [Yaşlilarda hipertansiyon prevalansi: Manisa örneǧi](2006) Altiparmak S.; Karadeniz G.; Altiparmak O.; Ataseven M.; Şahin R.Background: Hypertension is a social health problem prevalence of which increases with ageing. It is a serious disease that must not be underestimated, causing mortal complications like ischemic hearth diseases, cerebrovascular diseases etc. or organ handicaps. This study aimed to determine, with cross sectional analytic method, the prevalence of hypertension, risk factors and their interrelationships in the population above 64 years old in Manisa. Materials and Methods: Arterial blood pressures of 340 participants who are registered in the region systematic sampling method were measured and a questionnaire interrogating demographic features and was conducted by means of face-to-face interviews. Results: According to questionnaire results, the hypertension prevalence, which is actually 49.7%, was found to be 61.8% in all individuals above 65 years old. Out of elderly people 26.2% were normotensive, 27.1% were systolic hypertension, 8.6% were diastolic hypertension, 26.2% were systolo-diastolic hypertension. Hypertensive individuals have been compared in respect of age, gender, educational level, marital status was not statistically different between the groups. Body Mass Index made increase on risk score. Conclusion: Consequently, the hypertension prevalence among elderly in the study region was high. This result draws the attention once again to the fact that the screening for hypertension among the elderly people and adequate and equal nutrition is necessary.Item Prevalence of pseudoneurologic conversion disorder in an urban community in Manisa, Turkey(2007) Deveci A.; Taskin O.; Dinc G.; Yilmaz H.; Demet M.M.; Erbay-Dundar P.; Kaya E.; Ozmen E.Background: There is not a wide agreement upon rate of conversion disorder within Turkish population. The aim of this study was to determine the prevalence of conversion disorder with pseudoneurological symptoms or deficits and related risk factors in a city. Method: In total, 1,086 people, aged 15-65 years old, were selected from the city of Manisa, Turkey to take part in the study. We applied sociodemographic and health information questionnaires and the Composite International Diagnostic Interview (CIDI) Somatization Subscales to the samples. Results: The likelihood that an individual might have conversion disorder with pseudoneurological symptoms or deficits was found to be 5.6% (n = 61). The prevalence of conversion disorder with pseudoneurological symptoms or deficits was significantly higher among women (p < 0.0001), 15-24 year old women (p = 0.011) and 25-34 year old women (p = 0.003), people who live as squatters (p = 0.03), those with a history of psychiatric disorder (p < 0.0001) and those having a mother with a psychiatric disorder (p = 0.04). Conclusion: This study has shown the conversion disorder with pseudoneurological symptoms or deficits is inadequately frequent in the population. © Springer-Verlag 2007.Item Effect of severity of asthma on quality of life(2007) Şakar A.; Yorgancioǧlu A.; Aydemir Ö.; Sepit L.; Çelik P.This study is aimed to evaluate the health related quality of life (HRQL) in asthmatics and the probable association between HRQL and disease severity and also other demographic factors by using a generic scale, SF-36 questionnaire. One-hundred and two asthmatics were enrolled. The scores of the 8 domains of SF-36 questionnaire were evaluated according to age, gender, status of education and compared with the severity of asthma. The mean age of 84 (83%) female and 18 (17%) male patients was 42.86 ± 11.15. Fifty-two of them was well educated (51%) and 50 was poorly educated (49%). Atopy ratio was 81%. Mild intermittent, mild persistent and moderate-severe persistent groups were 27 (26%), 46 (45%) and 29 (29%) respectively. Female gender were worse in physical functioning (p= 0.000), physical role difficulties (p= 0.0049), vitality (p= 0.045) and social functioning (p= 0.025). Poorly educated group were worse in physical functioning (p= 0.001), physical role difficulties (p= 0.039), vitality (p= 0.045), emotional role difficulties (p= 0.046), general health (p= 0.030) and mental health (p= 0.044). Mental health was worse in the presence of atopy (p= 0.035). Physical functioning was better in mild intermittent group than moderate and severe persistent group (p= 0.024). General health was better in mild intermittent group than mild persistent group (p= 0.018), moderate and severe persistent group (p= 0.015). Vitality and emotional role difficulties was better in mild intermittent than mild persistent group (p= 0.042, p= 0.007). The HRQL scores and severity of asthma is well correlated like other objective parameters. So one of the primary goals in management of asthma should also improve QOL as well as functional parameters.Item Accident frequency of elderly in Manisa Muradiye Village Clinic and factors related to the accidents; [Manisa muradiye saǧlik ocaǧi bölgesinde yaşlilarda kaza sikliǧi ve kaza ile ilişkili factörler](2007) Cihan Atman Ü.; Dinç G.; Oruçoǧlu A.; Oǧurlu H.; Ecebay A.Introduction: Accidents of old age is an important health problem for the cases of morbidity and mortality. This study is planned to determine the frequency of accidents and related risk factors of people at the age of 65 or over in Manisa Muradiye Village Clinic. Materials and Method: The study is a cross sectional type of research. By the sistematic random sampling method, it is aimed to attain 327 people that are chosen among 652 people over 65, living in the region. 328 (98.7%) of these people are reached to gather data with the heip, of a questionnaire that is done by face-to-face interviews. Data are evaluated in SPSS for Windows 10.0 package programme, Odds Ratio and 95% confidence interval were used in statistical analysises. Results: 31.6% of the people in the research have had an accident during the last one year. According to the type of the accidents, most frequent type of accident is falling with 49.2%, second is injuries with 22.2 %, and third is clashing with 17.5 %. Accidents mostly happen at home in winter. Being a woman, living alone, not having any disability, forgetfulness are the factors related to accidents. It is seen that there aren't any interventions for half of the accidents, for 23% of the accidents a health institution is referred or a health personnel is asked for help, for the rest of the accidents there are inproper interventions. Conclusion: It is concluded that; accidents happen frequently at old ages; because of the reason that most of the accidents are happening at home, the house conditions must be arranged to prevent accidents; especialiy women and people living alone must be followed and educated about accidents.