Browsing by Subject "vancomycin"
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Item Antimicrobial resistance in streptococcus pneumoniae; [Streptococcus pneumoniae da antimikrobiyal direnc](1999) Surucuoglu S.The increasing rates of penicillin resistance in Streptococcus pneumoniae strains have been reported from various countries of the world, recently, and this process is due to the chromosomal changes of the genes coding penicillin binding proteins. The rates of resistance to penicillin are found 13-56% in different regions of our country. In order to investigate the penicillin susceptibility, oxacillin disc diffusion test is recommended by NCCLS. The difference between intermediate resistance and resistance of the strains should be evaluated by dilution tests or E-test. The most effective antibiotics to penicillin resistant pneumococci are cefotaxime, ceftriaxone, imipenem and vancomycin. As minimizing of penicillin resistance in pneumococci is very important, the prevalence of resistance rates should be determined by surveillance programs in each center, clinicians must be informed about the susceptibility results, and the rational use of antibiotics must be emphasized. Vaccination of the risk groups is also one of the most effective preventive methods.Item In vitro susceptibility of Staphylococcus aureus and coagulase-negative Staphylococcus strains to fusidic acid(2001) Tünger O.; Arsoy A.; Kurutepe S.; Akçal S.; Özbakkalolu B.[No abstract available]Item Trends in antimicrobial resistant staphylococci in an university hospital over a 6-year period(Elsevier, 2001) Tünger O.; Özbakkalolu B.; Aksoy H.[No abstract available]Item Septic pulmonary emboli presenting with deep venous thrombosis secondary to acute osteomyelitis(2004) Yüksel H.; Özgüven A.A.; Akil I.; Ergüder I.; Yilmaz D.; Çabuk M.[No abstract available]Item Antimicrobial screening of some Turkish medicinal plants(2007) Oskay M.; Sari D.Ethanol extracts of 19 Turkish medicinal plants, used in the traditional system of medicine, were investigated for their antimicrobial activity against 14 pathogenic bacterial species and a yeast, Candida albicans, using the agar well diffusion method. Anticandidal activity was detected in 10 plant extracts. Extracts of Eucalyptus camuldulensis (leaves), Rosmarinus officinalis (leaves), Ecballium elaterium (leaves, fruits; 2:1, v/v), Liquidambar orientalis (leaves), Cornus sanguinea (leaves, flowers, stems; 2:1:1, v/v/v), Vitis vinifera (leaves, raw fruits, young branches; 2:1:1, v/v/v), Inula viscosa (leaves), Hypericum perforatum (leaves, flowers, stems; 2:1:1, v/v/v), and Punica granatum (leaves, flowers; (2:1, v/v) showed broad-spectrum antimicrobial activity with inhibition zones ranging from 4 to 34 mm. The most resistant organisms were Escherichia coli, Candida albicans, Pseudomonas fluorescens, Bacillus subtilis ATCC 6683, and Enterobacter faecalis ATCC 29212, and the most susceptible species were Proteus vulgaris ATCC 6997, Salmonella typhimurium CCM 5445, Staphylococcus epidermidis ATCC 12228, and Serratia marcescens CCM 583, respectively. The minimum inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) were determined for the seven highly active plants that showed antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 95047 (MRSA), E. coli, and C. albicans. The MICs of active extracts ranged from 8 to 14.2 mg/mL while the MBCs were 14.2 to 24.4 mg/mL. © 2007 Informa Healthcare.Item Antifungal and antibacterial compounds from Streptomyces strains(2009) Oskay M.Sixteen antibiotic-producing Streptomyces sp. isolated from the North Cyprus soils were evaluated for their ability to inhibit in vitro against six filamentous fungi including human and plant pathogens. One promising strain, designed as KEH23 with strong antifungal activity, was selected for further studies. This isolate was identified as Streptomyces sp. based on a great variety of morphological, cultural, physiological and biochemical characteristics. Its antifungal activity was confirmed in batch culture. In order to standardize the antibiotic production some cultural conditions like different incubation temperatures (20.0, 25.0, 30.0 and 37.0°C), carbon sources (glucose, glycerol, starch and sucrose), pH (6.0, 7.0, 7.5, 8.0 and 9.0) and incubation time in hours (24, 48, 72, 96 and 120) were determined. During fermentation, growth, pH and antibiotic production were monitored at 12 h intervals. Penicillium sp. was most sensitive to the produced compound(s) followed by Candida albicans, Cladosporium oxysporum and Alternaria alternata with an inhibition zone 28.0, 20.0, 16.0 and 15.0 mm, respectively. In addition, antibacterial activity of this strain was determined against human pathogenic bacteria such as Staphylococcus aureus, Klebsiella pneumoniae, Kocuria rhizophila, Escherichia coli, Salmonella typhimurium and methicillin-resistant Staphylococcus aureus (MRSA). The present results indicate that isolate KEH23 is a potential antibiotic producer agent for the biocontrol of plant and human pathogens. © 2009 Academic Journals.Item Native valve endocarditis caused by streptococcus bovis following colonoscopy; [Kolonoskopi̇ sonrasi görülen streptococcus bovise baǧli doǧal kapak endokardi̇ti̇](2010) Kahraman N.; Iskesen I.; Kurdal A.T.; Ozbakkaloglu A.; Hayrettin B.The strongest relationship focuses on Streptococcus bovis. All types of Streptococcus bovis infection have been related to the presence of a gastrointestinal neoplasia, which in most cases is colonic adenoma or carcinoma. We report the case of a patient who was diagnosed with villous adenoma of the colon and underwent aortic valve replacement because of a large vegetation on the aortic valve caused by Streptococcus Bovis endocarditis.48 years old male patient with a history of abdominal pain and weight loss for the last 1.5 months was diagnosed with villous adenoma. 1 week after his colonoscopy the patient presented to our clinic with tachycardia, fever, fatique, and swelling of the feet. In echocardiographic evaluation a 4.5x1.1 cm mobile mass filling the aortic lumen almost totally and reaching the mitral valve region and 3rd degree aortic regurgitation was found. The postoperative course was uneventful. After the first postoperative month the patient was transferred to general surgery clinic. Streptococcus Bovis endocarditis is normaly very uncommon. Since Streptococcus Bovis endocarditis is strongly associated with emboli, urgent operation should be planned and the vegetation should be removed.Item Antimicrobial susceptibility and resistance mechanisms of methicillin resistant Staphylococcus aureus isolated from 12 Hospitals in Turkey(BioMed Central Ltd., 2014) Yildiz T.; Çoban A.Y.; Şener A.G.; Coşkuner S.A.; Bayramoğlu G.; Güdücüoğlu H.; Özyurt M.; Tatman-Otkun M.; Karabiber N.; Özkütük N.; Aktepe O.; Öncü S.; Arslan U.; Bozdoğan B.Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most important nosocomial pathogens and is also emerging in Turkish hospitals. The aim of this study was to determine the antimicrobial susceptibility profiles of MRSA isolated from Turkish hospitals. Materials and methods: A total of 397 MRSA strains isolated from 12 hospitals in Turkey were included to present study. Antimicrobial susceptibilities were tested using agar dilution method. Presence of ermA, ermB, ermC, msrA, tetM, tetK, linA and aac-aph genes were studied by PCR. Results: All strains were susceptible to vancomycin and linezolid. The susceptibility rates for fusidic acid, lincomycin, erythromycin, tetracyclin, gentamycin, kanamycin, and, ciprofloxacin were 91.9%, 41.1%, 27.2%, 11.8%, 8.5%, 8.3% and 6.8%, respectively. Lincomycin inactivation was positive for 3 isolates. Of 225 erythromycin resistant isolates 48 had ermA, 20 had ermC, and 128 had ermA-C. PCR was negative for 15 strains. Of 3 isolates with lincomycin inactivation one had linA and msrA. Of 358 gentamycin resistant isolates 334 had aac-aph and 24 were negatives. Among 350 tetracyclin resistant isolates 314 had tetM. Of 36 tetM negative isolates 10 had tetK. Conclusion: MRSA isolates from Turkish hospitals were multiresistant to antimicrobials. Quinolone and gentamycin resistance levels were high and macrolide and lincosamide resistance were relatively low. Susceptibility rates for fusidic asid were high. Linezolide and vancomycin resistance are not emerged. The most common resistance genes were ermA, tetM and aac-aph. Evolution of antimicrobial susceptibilities and resistance genes profiles of MRSA isolates should be surveyed at regional and national level for accurate treatment of patients and to control dissemination of resistance genes. © 2014 Yildiz et al.; licensee BioMed Central Ltd.Item Variables determining mortality in patients with Acinetobacter baumannii meningitis/ventriculitis treated with intrathecal colistin(Elsevier B.V., 2017) Ceylan B.; Arslan F.; Sipahi O.R.; Sunbul M.; Ormen B.; Hakyemez İ.N.; Turunc T.; Yıldız Y.; Karsen H.; Karagoz G.; Tekin R.; Hizarci B.; Turhan V.; Senol S.; Oztoprak N.; Yılmaz M.; Ozdemir K.; Mermer S.; Kokoglu O.F.; Mert A.Aim To examine the variables associated with mortality in patients with Acinetobacter baumannii-related central nervous system infections treated with intrathecal colistin. Materials and methods This multi-centre retrospective case control study included patients from 11 centres in Turkey, as well as cases found during a literature review. Only patients with CNS infections caused by multidrug-resistant or extensively drug-resistant Acinetobacter baumannii treated with intrathecal colistin were included in this study. The variables associated with mortality were determined by dividing the patients into groups who died or survived during hospitalisation, and who died or survived from Acinetobacter meningitis. Results Among the 77 cases enrolled in the study, 35 were found through a literature review and 42 were cases from our centres. Forty-four cases (57.1%) were male and the median age was 48 years (range: 20–78 years). Thirty-seven patients (48%) died during hospitalisation. The variables associated with increased all-cause mortality during hospitalisation included old age (odds ratio, 1.035; 95% confidence interval (CI), 1.004–1.067; p = 0.026) and failure to provide cerebrospinal fluid sterilisation (odds ratio, 0.264; 95% confidence interval, 0.097–0.724; p = 0.01). There is a trend (P = 0.062) towards higher mortality with using of meropenem during meningitis treatment. Fifteen cases (19%) died from meningitis. There were no significant predictors of meningitis-related mortality. Conclusions The mortality rate for central nervous system infections caused by multidrug-resistant or extensively drug-resistant Acinetobacter baumannii is high. Old age and failure to provide CSF sterilisation are associated with increased mortality during hospitalisation. © 2016Item Aortic Injury by Thoracic Pedicle Screw. When Is Aortic Repair Required? Literature Review and Three New Cases(Elsevier Inc., 2019) Kayacı S.; Cakir T.; Dolgun M.; Cakir E.; Bozok Ş.; Temiz C.; Caglar Y.S.Purpose: Aortic injury by pedicle screw is rare but can cause serious complications. It has not been clearly determined when aortic repair is necessary in cases of screw impingement without perforation of the aortic wall. In this article, we review the treatment and clinical course of pedicle screw aortic impingement and attempt to clarify this issue. Methods: Cases of aortic injury during thoracic screw procedures were found using a MEDLINE search and analyzed together with 3 new cases that we present. Results: Nineteen cases collected from the literature and 3 new cases were included in the study. In 7 of the cases, aortic impingement by the pedicle screw was detected during postoperative follow-up (day 1) radiologic examinations. In the other cases, time to presentation of aortic impingement ranged between 2 weeks and 60 months after fixation. The main indications for thoracic spinal fixation were post-traumatic vertebral fracture and kyphoscoliosis/scoliosis. Repair of the aortic damage ranged from primary repair to stent and tube graft placement by the thoracic endovascular aortic repair method. Conclusions: In cases in which the screw impinges less than 5 mm into the aortic wall, hardware revision without aortic repair may be sufficient if recognized early and there are no sign of aortic leakage in vascular imaging. However, cases with more than 5 mm of screw impingement should undergo aortic repair first, even in the absence of aortic leakage, following by screw revision. © 2019Item Serum Vitamin D Levels in Relation to Development of Multisystem Inflammatory Syndrome in Pediatric COVID-19(Georg Thieme Verlag, 2022) Zengin N.; Bal A.; Goren T.A.; Bayturan S.S.; Alkan F.; Akcali S.Objective The aim of the study is to evaluate vitamin D (vit D) levels in children with and without development of multisystem inflammatory syndrome in children (MIS-C) after coronavirus disease 2019 (COVID-19) and also between those with severe and moderate MIS-C. Methods This comprises retrospective data of 68 patients including 34 patients with MIS-C and admitted into the pediatric intensive care unit (MIS-C group) and 34 patients without MIS-C (non-MIS-C group) were analyzed for their presenting characteristics, serum vit D levels, ventilatory needs, and prognostic scores. Results Vit D levels were significantly lower in patients with versus without MIS-C [9 (2-18) vs. 19 (10-43) ng/mL, p <0.001], and also in patients with severe versus moderate MIS-C [7.5 (2-17) vs. 9 (5-18) ng/mL, p = 0.024]. Vit D deficiency (levels <12 ng/mL) was more common in the MIS-C versus non-MIS-C group (79.4 vs. 11.8%, p <0.001) and in severe versus moderate MIS-C (92.9 vs. 70.0%, p <0.001). The severe versus moderate MIS-C was associated with significantly higher levels of procalcitonin [7.6 (0.9-82) vs. 1.7 (0.2-42) ng/mL, p = 0.030] and troponin [211 (4.8-4,545) vs. 14.2 (2.4-3,065) ng/L, p = 0.008] and higher likelihood of reduced ejection fraction (75.0 vs. 15.4%, p = 0.004). Conclusion Our findings indicate the higher prevalence of vit D deficiency in pediatric COVID-19 patients with versus without MIS-C, as well as in those with severe versus moderate MIS-C. Higher troponin and procalcitonin levels and dyspnea at presentation seem also to be risk factors for severe MIS-C, more pronounced cardiac dysfunction, and poorer prognosis. © 2022 Georg Thieme Verlag. All rights reserved.Item Acute kidney disease beyond day 7 after major surgery: a secondary analysis of the EPIS-AKI trial(Springer Science and Business Media Deutschland GmbH, 2024) Meersch M.; Weiss R.; Strauß C.; Albert F.; Booke H.; Forni L.; Pittet J.; Kellum J.A.; Rosner M.; Mehta R.; Bellomo R.; Rosenberger P.; Zarbock A.; Makhloufi H.; Sakhraoui R.; Ouyahia A.; Rais M.; Kouicem A.T.; Derwish K.; Abdoun M.; Ouahab I.; Bouaoud S.; Tidjane A.; Pérez Rivera C.J.; García J.P.; Peng K.; Ji F.-H.; Ma Z.-M.; Elbahnasawy M.G.; Elsalhawy S.; Nafea A.M.; Osman N.A.; Emara M.M.; Bonna M.M.; Abdehaleem I.A.; Abbas A.M.; Abbas M.S.; Esmaeil H.M.; Joannes-Boyau O.; Legros V.; Floch T.; Muccio S.; Menage-Innocenti L.; Brochet B.; Leclercq-Rouget M.; Geneve C.; Mocarquer B.V.; Aveline C.; Vautier P.; Nadaud J.; Rimmelé T.; Cerro V.; Suria S.; Elmawieh J.; El-Jawiche R.; Cirenei C.; Lebuffe G.; Ponsonnard S.; Egreteau P.-Y.; Ichai C.; Jean-Michel V.; Léger M.; Lasocki S.; Masson C.; Rineau E.; Cassisa V.; Verrier P.; Atchade E.; Rochon C.-E.; Quentin V.; Queixalos N.; Braun T.; Grand H.; Mayeur N.; Pasquie M.; Garçon P.; Bruckert V.; Pradel G.; Ramorasata A.; Ravry C.; Mottard N.; von Groote T.; Dörr C.; Küllmar M.; Massoth C.; Motekallemi A.; Saadat-Gilani K.; Kerschke L.; Storck M.; Varghese J.; Wempe C.; Grüßer L.; Kowark A.; Brandenburger T.; Hohn A.; Häberle H.; Hofmann P.; Kuhle J.; Calov S.; Bernard A.M.; Mirakaj V.; Weber K.; Pfister K.; Stetz L.; Müller S.D.; Klaus S.; Sadlo M.; Sengelhoff C.; Stenger C.-K.; Göbel U.; Heringlake M.; Arnaoutoglou E.; Stratigopoulou P.; Danai P.; Dimakopoulou A.; Menis A.-A.; Ioannidis O.; Jalaawiy H.; Anwar A.; Hashim H.T.; Rasheed Aldawoody H.I.; Cortegiani A.; Ippolito M.; Marino C.; Presti G.; Fricano D.C.; De Rosa S.; Bianchin A.; Paternoster G.; Fasciano U.; Cutuli S.L.; Savino S.; Enrico B.; Marco P.; Alberto V.C.; Tripodi V.F.; Fiume D.; Iuorio A.; Santorsola C.; Abu-Hussein B.; Hasanein K.; Shin S.; Baek J.; Kim S.; Elhadi M.; Aldressi W.; Abuzeid I.A.; Albaraesi M.N.; Moftah M.A.; Aldressi S.; Khalel W.; Abdulwahed E.; Ali Alshareea E.A.; Abujrad Reem Ghmagh A.A.A.; Biala M.I.; Benjouira R.A.I.; Aliwa M.; Msherghi A.; Tuwaib A.; Mustafa T.; Zriba H.; Agilla H.M.; Sadek Ben Hamida B.T.; Mohamed Otman R.H.; Mijovska M.M.; Podesta A.M.C.; Gasca López G.A.; Amro S.; de Freitas Regufe R.; Grigoryev E.; Ivkin A.; Balakhnin D.; Shukevich D.; Yaroustovsky M.; Barmou A.; Kaserer A.; Castellucci C.; Akbas S.; Petrun A.M.; Gregorcic I.; Sok V.; Links A.; Barreto E.B.; Melchor J.R.; Becerra-Bolaños Á.; Rodríguez-Pérez A.; Estévez J.M.; Matas J.M.; Palao S.P.; Álvarez M.G.; Albadalejo A.B.; González A.B.; Caro A.M.G.; Blanco I.H.; Fernandez D.T.; Perez G.H.; Ejea M.L.; de la Rosa Ruiz N.; Abasolo M.G.; Ferreira L.; Lobato F.; Sevilla M.A.; Erazo A.; Paulis B.C.; de la Calle Gil I.; Adamove P.; Blasco F.M.B.; García-Sánchez J.I.; Zamorano S.G.; Herreros N.G.; Callejas R.; Gómez M.E.; Candela-Toha A.M.; Claros-Llamas E.; Cobeta-Orduña P.; Crespo-Aliseda P.; Dorado-Díaz T.; Gómez-Rojo M.; Mané-Ruiz M.N.; González M.C.M.; Martínez-Pérez A.; Tiscar C.; Menéndez P.G.; Calvo V.E.; Espí L.L.; Aldeán Y.S.L.; Ariza V.M.; Vila L.V.; García-Miguel F.J.; Suliman E.S.M.; Ibrahim A.M.; Fadlalmola H.A.; Swed S.; Wu V.-C.; Orhan-Sungur M.; Altun D.; Canbolat N.; Dinçer M.B.; Yildirim S.A.; Iyigun M.; Yapıcı D.; Özdemir L.; Sagün A.; Boztug N.; Gündüz E.; Lafli-Tunay D.; Karakaya D.; Dost B.; Komurcu O.; Dilmen O.K.; Akcil E.F.; Tunali Y.; Ok G.; Tok-Alsina E.; Polat C.; Kızılcık N.; Şen Ö.; Darçın K.; Uğur S.; Gürkan Y.; Saracoglu K.T.; Yıldız-Koyuncu Ö.; Demir Z.A.; Postacı N.A.; Özgök A.; Karadeniz Ü.; Özay H.Y.; Balcı E.; Salman N.; Girgin B.; Sagir O.; Demir H.F.; Ugun F.; Toprak H.İ.; Özcan M.S.; Alkaya-Solmaz F.; Yilmaz M.; Karaca U.; Şahin S.H.; Erkoç S.K.; Alkış N.; Baytaş V.; Erturk E.; Saylan S.; Akdogan A.; Yeşil B.B.; Boran O.F.; Orak Y.; Çalişir F.; Büyükçoban S.; Kuvaki B.; Cansabuncu S.; Akesen S.; Gören S.; Yeniocak T.; Orman O.; Karka Ö.E.; Sahin T.; Momot N.; Panchenko A.; Rutledge K.Purpose: Acute kidney disease (AKD) is a significant health care burden worldwide. However, little is known about this complication after major surgery. Methods: We conducted an international prospective, observational, multi-center study among patients undergoing major surgery. The primary study endpoint was the incidence of AKD (defined as new onset of estimated glomerular filtration rate (eCFR) < 60 ml/min/1.73 m2 present on day 7 or later) among survivors. Secondary endpoints included the relationship between early postoperative acute kidney injury (AKI) (within 72 h after major surgery) and subsequent AKD, the identification of risk factors for AKD, and the rate of chronic kidney disease (CKD) progression in patients with pre-existing CKD. Results: We studied 9510 patients without pre-existing CKD. Of these, 940 (9.9%) developed AKD after 7 days of whom 34.1% experiencing an episode of early postoperative-AKI. Rates of AKD after 7 days significantly increased with the severity (19.1% Kidney Disease Improving Global Outcomes [KDIGO] 1, 24.5% KDIGO2, 34.3% KDIGO3; P < 0.001) and duration (15.5% transient vs 38.3% persistent AKI; P < 0.001) of early postoperative-AKI. Independent risk factors for AKD included early postoperative-AKI, exposure to perioperative nephrotoxic agents, and postoperative pneumonia. Early postoperative-AKI carried an independent odds ratio for AKD of 2.64 (95% confidence interval [CI] 2.21–3.15). Of 663 patients with pre-existing CKD, 42 (6.3%) had worsening CKD at day 90. In patients with CKD and an episode of early AKI, CKD progression occurred in 11.6%. Conclusion: One in ten major surgery patients developed AKD beyond 7 days after surgery, in most cases without an episode of early postoperative-AKI. However, early postoperative-AKI severity and duration were associated with an increased rate of AKD and early postoperative-AKI was strongly associated with AKD independent of all other potential risk factors. © The Author(s) 2024.