Does Second Trimester Maternal Serum Zonulin Level Predict Gestational Diabetes Mellitus?

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dc.contributor.authorTonyalı N.V.
dc.contributor.authorArslan B.
dc.contributor.authorSucu S.T.
dc.contributor.authorSarsmaz K.
dc.contributor.authorİbanoğlu M.C.
dc.contributor.authorÖrgül G.
dc.contributor.authorAktemur G.
dc.contributor.authorYücel A.
dc.contributor.authorŞahin D.
dc.date.accessioned2024-07-22T08:01:50Z
dc.date.available2024-07-22T08:01:50Z
dc.date.issued2024
dc.description.abstractZonulin, a protein that regulates intestinal permeability, has attracted attention as a potential biomarker for GDM. Therefore, this study aims to investigate whether there are differences in zonulin levels between the GDM group and control groups, especially between those receiving different treatments (diet and insulin). Based on this idea, we included 90 patients with a gestational age between 24 and 28 weeks in our study. While GDM was not detected in 33 of these patients, as a result of OGTT, 57 patients were diagnosed with GDM and these patients were followed throughout their pregnancy. Gestational diabetes was diagnosed by an OGTT performed between 24 and 28 weeks of gestation according to American Diabetes Association (ADA) standards. During follow-up, GDM patients were divided into two groups according to whether they required insulin treatment. Plasma zonulin levels were determined using enzyme-linked immunosorbent assay (ELISA) techniques. The GDM group had significantly higher plasma zonulin levels than the control group (p < 0.005). According to our research, zonulin may be a non-invasive biomarker involved in the etiology of GDM. Large-scale research on this topic is still needed. © 2024 by the authors.
dc.identifier.DOI-ID10.3390/jcm13020394
dc.identifier.issn20770383
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11596
dc.language.isoEnglish
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.rightsAll Open Access; Gold Open Access
dc.subjectinsulin
dc.subjectprotein
dc.subjectunclassified drug
dc.subjectzonulin
dc.subjectadult
dc.subjectApgar score
dc.subjectArticle
dc.subjectbody mass
dc.subjectclinical feature
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectdemographics
dc.subjectdiabetes mellitus
dc.subjectdiet
dc.subjectfamily history
dc.subjectfemale
dc.subjectfollow up
dc.subjectgestational age
dc.subjectgestational diabetes
dc.subjecthuman
dc.subjectinsulin treatment
dc.subjectmajor clinical study
dc.subjectmaternal age
dc.subjectoral glucose tolerance test
dc.subjectpolyhydramnios
dc.subjectpregnant woman
dc.subjectpremature labor
dc.subjectsecond trimester pregnancy
dc.subjectsensitivity and specificity
dc.titleDoes Second Trimester Maternal Serum Zonulin Level Predict Gestational Diabetes Mellitus?
dc.typeArticle

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