Syntheses of 1,2,3-triazole-bridged pyranose sugars with purine and pyrimidine nucleobases and evaluation of their anticancer potential
| dc.contributor.author | Halay, E | |
| dc.contributor.author | Ay, E | |
| dc.contributor.author | Salva, E | |
| dc.contributor.author | Ay, K | |
| dc.contributor.author | Karayildirim, T | |
| dc.date.accessioned | 2025-04-10T10:36:26Z | |
| dc.date.available | 2025-04-10T10:36:26Z | |
| dc.description.abstract | With the aim to create a library of compounds with potential bioactivities by combining special characteristics of two important groups such as nucleobases and carbohydrates, twenty 1,4-disubstituted-triazole nucleosides were synthesized in good yields (80-94%) using the copper catalyzed Click' reaction between azido-modified pento- or hexopyranoses and alkyne-bearing pyrimidine or purine nucleobases. Structural elucidation was made with the assistance of spectroscopic techniques such as FTIR, 1D-, 2D-NMR, and ESI-TOFMS. All the synthesized triazole nucleosides were evaluated for their cytotoxic activity against three human cancer cell lines (MDA-MB-231, Hep3B, PC-3) by using the MTT assay. Particularly, compounds 3a and 1b were identified as potential hits against Hep3B cell. | |
| dc.identifier.e-issn | 1532-2335 | |
| dc.identifier.issn | 1525-7770 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/42289 | |
| dc.language.iso | English | |
| dc.title | Syntheses of 1,2,3-triazole-bridged pyranose sugars with purine and pyrimidine nucleobases and evaluation of their anticancer potential | |
| dc.type | Article |