Oxidative status of colitis-associated cancer model induced by azoxymethane/dextran sulfate sodium and the effects of COX-2 inhibitor in mice; [Farelerde azoksimetan/dekstran sülfat sodyum ile oluşturulan kolit ile ilişkili kanser modelinde oksidatif durum ve COX-2 inhibitörünün etkileri]

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dc.contributor.authorKismali G.
dc.contributor.authorÜner A.G.
dc.contributor.authorMeral Ö.
dc.contributor.authorAlpay M.
dc.contributor.authorSalmanoğlu B.
dc.contributor.authorÜlker Çakir D.
dc.contributor.authorKosova F.
dc.contributor.authorSel T.
dc.date.accessioned2024-07-22T08:09:01Z
dc.date.available2024-07-22T08:09:01Z
dc.date.issued2019
dc.description.abstractNatural products and anti-inflammatory agents including cyclooxygenase-2 (COX-2) inhibitors which is a type of nonsteroidal anti-inflammatory drugs (NSAIDs) are highly considerable interest for the prevention of carcinogenesis. The objective of this study is to evaluate the oxidative status of colitis-associated cancer induced by azoxymethane (AOM)/dextran sulfate sodium (DSS), and the effects of COX-2 inhibitor in mice. Totally 40 mice were randomized and divided to four groups. All animals except control and Cox-2 inhibitor alone group received AOM/DSS to establish colitis-associated cancer model as reported elsewhere. COX-2 preferential inhibitor meloxicam was used to minimize side effects such as gastrointestinal hemorrhage. Meloxicam were used (5mg/kg, intraperitoneal) three times a week with meloxicam alone and AOM/DSS + meloxicam group. Superoxide dismutase (SOD), Glutathione peroxidase (GPx), Malondialdehyde (MDA) and Advanced Oxidation Protein Products (AOPP) which all of them are oxidative stress markers were measured by spectrophotometrically. The combination treatment of Meloxicam and AOM/DSS significantly increased (P< 0.05) SOD activities in mice. GPx activities were found significantly increased (P< 0.05) in Meloxicam and AOM/DSS combinations or alone. There were no differences between the control and treatment groups of MDA levels. AOPP levels of Meloxicam and AOM/DSS combination group were found higher than the other groups. Meloxicam and/or AOM/DSS treatment not caused lipid peroxidations, but increased the antioxidant enzymes and Advanced Oxidation Protein Products levels. © 2019, Chartered Inst. of Building Services Engineers. All rights reserved.
dc.identifier.DOI-ID10.33988/auvfd.521040
dc.identifier.issn13000861
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14631
dc.language.isoEnglish
dc.publisherChartered Inst. of Building Services Engineers
dc.rightsAll Open Access; Gold Open Access
dc.subjectadvanced oxidation protein product
dc.subjectazoxymethane
dc.subjectcyclooxygenase 2 inhibitor
dc.subjectdextran sulfate
dc.subjectglutathione peroxidase
dc.subjectmalonaldehyde
dc.subjectmeloxicam
dc.subjectsuperoxide dismutase
dc.subjectthiobarbituric acid reactive substance
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectcancer model
dc.subjectclinical assessment
dc.subjectcolitis
dc.subjectcolon carcinogenesis
dc.subjectcolorimetry
dc.subjectcontrolled study
dc.subjectenzyme activity
dc.subjectfemale
dc.subjectgastrointestinal hemorrhage
dc.subjectlipid peroxidation
dc.subjectmouse
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectspectrophotometry
dc.titleOxidative status of colitis-associated cancer model induced by azoxymethane/dextran sulfate sodium and the effects of COX-2 inhibitor in mice; [Farelerde azoksimetan/dekstran sülfat sodyum ile oluşturulan kolit ile ilişkili kanser modelinde oksidatif durum ve COX-2 inhibitörünün etkileri]
dc.typeArticle

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