Histopathological and audiological effects of mechanical trauma associated with the placement of an intracochlear electrode, and the benefit of corticosteroid infusion: Prospective animal study

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dc.contributor.authorMalkoc G.
dc.contributor.authorDalgic A.
dc.contributor.authorKoc M.
dc.contributor.authorKandogan T.
dc.contributor.authorKorkmaz S.
dc.contributor.authorCeylan M.E.
dc.contributor.authorInan S.
dc.contributor.authorOlgun L.
dc.date.accessioned2024-07-22T08:16:15Z
dc.date.available2024-07-22T08:16:15Z
dc.date.issued2014
dc.description.abstractObjective: This study aimed to present the histopathological and audiological effects of mechanical trauma associated with the placement of a model electrode in the scala tympani in rats, and the effects of continuous topical corticosteroid application. Method: The study comprised three groups of rats. The round window membrane was perforated in all three groups and a model electrode was inserted in the round window. Group one received no further treatments. Groups two and three also had an intrathecal microcatheter compatible with a mini-osmotic pump inserted; in group two this was used to release normal saline and in group three the pump released 400 μg/ml dexamethasone. Results: Dexamethasone infusion given after implantation of the intracochlear model electrode was more effective for preventing hearing loss than the administration of just one dose of dexamethasone. Conclusion: The findings suggest that continuous dexamethasone infusion is beneficial for preventing the loss of hair cells and neurons associated with early and late periods of intracochlear electrode trauma. Copyright © JLO (1984) Limited 2014.
dc.identifier.DOI-ID10.1017/S002221511400156X
dc.identifier.issn00222151
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16817
dc.language.isoEnglish
dc.subjectAdministration, Topical
dc.subjectAdrenal Cortex Hormones
dc.subjectAnimals
dc.subjectAudiometry
dc.subjectCochlea
dc.subjectCochlear Implants
dc.subjectDexamethasone
dc.subjectFemale
dc.subjectRats
dc.subjectRound Window, Ear
dc.subjectdexamethasone
dc.subjectsodium chloride
dc.subjectcorticosteroid
dc.subjectdexamethasone
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectaudiology
dc.subjectcochlea fenestra
dc.subjectcontrolled study
dc.subjectcorticosteroid therapy
dc.subjectdrug infusion
dc.subjectear injury
dc.subjecteardrum perforation
dc.subjectfemale
dc.subjecthearing impairment
dc.subjecthistopathology
dc.subjectimplantation
dc.subjectintracochlear prosthesis
dc.subjectmicrocatheter
dc.subjectnonhuman
dc.subjectosmotic pump
dc.subjectprospective study
dc.subjectrat
dc.subjectscala tympani
dc.subjectsignal noise ratio
dc.subjecttopical treatment
dc.subjectadverse effects
dc.subjectanimal
dc.subjectaudiometry
dc.subjectcochlea
dc.subjectcochlea prosthesis
dc.subjectpathology
dc.subjectpathophysiology
dc.subjectsurgery
dc.subjecttopical drug administration
dc.titleHistopathological and audiological effects of mechanical trauma associated with the placement of an intracochlear electrode, and the benefit of corticosteroid infusion: Prospective animal study
dc.typeArticle

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