Thymosin in the treatment of HBeAG-negative chronic hepatitis B

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dc.contributor.authorSaruc M.
dc.contributor.authorOzden N.
dc.contributor.authorYuceyar H.
dc.date.accessioned2024-07-22T08:24:48Z
dc.date.available2024-07-22T08:24:48Z
dc.date.issued2003
dc.description.abstractChronic hepatitis B virus (HBV) infection, which can lead to cirrhosis and hepatocellular carcinoma, is a major health threat worldwide. Classic patients with chronic hepatitis B are positive for hepatitis Be-antigen (HBeAg) and HBV-DNA. In the Mediterranean basin, 30-80% of patients with chronic hepatitis B (CHB) are HBeAg-negative, in contrast to Northern European countries and the US, where only 10-40% of CHB patients are lacking HbeAg. HBeAg-negative CHB usually runs a progressive course. The greatest problem with the treatment of HBeAg-negative CHB is the high relapse rate. Their end treatment response rates are similar to those of classic CHB patients, but after discontinuation of treatment most of them relapse. All the data available in the literature show that more than 80% of patients with HBeAg-negative CHB do not respond to the current approved therapies. A literature review and our experience with thymosin indicate that the combination of IFN α2b and T-α1 is better tolerated and more likely to induce a sustained response in HbeAg-negative chronic hepatitis B patients when compared to other currently available therapies. As thymosin-α1 treatment is relatively free from adverse effects, future controlled trials are needed, with a longer follow-up, in order to fully evaluate the role of the combination therapy of thymosin-α1 with other emerging therapeutic agents.
dc.identifier.issn12341010
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20141
dc.language.isoEnglish
dc.subject2-Aminopurine
dc.subjectAntiviral Agents
dc.subjectDrug Therapy, Combination
dc.subjectHepatitis B e Antigens
dc.subjectHepatitis B, Chronic
dc.subjectHumans
dc.subjectInterferons
dc.subjectLamivudine
dc.subjectReverse Transcriptase Inhibitors
dc.subjectThymosin
dc.subjectalpha2 interferon
dc.subjectfamciclovir
dc.subjecthepatitis B(e) antigen
dc.subjectlamivudine
dc.subjectthymosin alpha1
dc.subjectvirus DNA
dc.subjectchronic hepatitis
dc.subjectdisease course
dc.subjectdose response
dc.subjectdrug tolerability
dc.subjecthepatitis B
dc.subjectHepatitis B virus
dc.subjecthuman
dc.subjectliver cell carcinoma
dc.subjectliver cirrhosis
dc.subjectrelapse
dc.subjectreview
dc.subjecttreatment outcome
dc.subjecttreatment planning
dc.titleThymosin in the treatment of HBeAG-negative chronic hepatitis B
dc.typeReview

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