The relationship of pregnancy complications and AFP, HCG and estriol level detected in maternal serum; [Maternal kanda AFP, HCG ve ankonjuge östriol düzeylerinin gebelik komplikasyonlari i̇le i̇lişkisi]

Bülbül Baytur Y.; Ulman C.; Laçin S.; Özçakir H.T.; Taneli F.; Çelik T.; Uyar Y.

The relationship of pregnancy complications and AFP, HCG and estriol level detected in maternal serum; [Maternal kanda AFP, HCG ve ankonjuge östriol düzeylerinin gebelik komplikasyonlari i̇le i̇lişkisi]

Date

2004

Authors

Abstract

OBJECTIVE: The aim of the study was to determine the relationship of intrauterine death, prematurity, intrauterine growth retardation, surmaturation and preeclampsia with high and low AFP. high HCG and low estriol levels detected in maternal serum. STUDY DESING: 1020 patients who had undergone tripple test during pregnancy for intrauterine death, prematurity, surmaturation, intrauterine growth retardation and preeclampsia rates between 1999-2003 at Celal Bayar University Hospital were determined. The patients with high AFP levels (>2 MoM), high HCG levels (>2 MoM), low AFP levels (<0.5 MoM) and low estriol levels (<0.5 MoM) were compared to those with normal levels. The relationship of pregnancy complications and our findings examined. Statistical analysis were done with student t test and Chi square test by using SPSS for Windows version 10.0. RESULTS: Among 428 patients of whose files were useful for inclusion criteria, 30 of 31 patients of whom tripple test results were over the critical limit; 1/270 had undergone amniosynthesis. 4 of those 30 had Down syndrome. No other Down syndrome detected in other 26 patients who had a risky tripple test result neither with amniosynthesis nor in delivery. There were 14 patients with high AFP (>2 MoM). 55 patients with high HCG (>2 MoM), 13 patients with low AFP (<0.5 MoM) and 8 patients with low estriol levels (<0.5 MoM) among the patients those included to the study group. Those patients compared to the others with normal findings which consisted of 317 pregnants. There was statistically significant difference between low estriol levels and prematurity (p<0.05), however, there was no difference between high or low AFP levels and pregnancy complications. High HCG was significantly related with preeclampsia (p<0.05). CONCLUSION: Preeclampsia develoment with high HCG levels and the relation between low estriol and prematurity indicate that the patients with abnormal findings of tripple test are under the risk of obstetric complications. These patients should be consulted carefully for obstetric complications in addition to detection of cromozomal abnormality and malformation.