Preparation of hollow pcl microspheres by o/w single emulsion-solvent evaporation method in the presence of graphene nanopowders

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dc.contributor.authorDeliormanlı A.M.
dc.contributor.authorYenice A.C.
dc.date.accessioned2024-07-22T08:06:36Z
dc.date.available2024-07-22T08:06:36Z
dc.date.issued2021
dc.description.abstractPoly-ε-caprolactone (PCL) microspheres containing graphene nanopowders were prepared by oil-in-water (o/w) emulsion solvent-evaporation technique. For the emulsification study, an oil phase (PCL solution in dichloromethane or chloroform) and a water phase (3 wt% aqueous polyvinyl alcohol solution) was utilized. Effect of solvent type, stirring speed, and graphene addition on the structural and morphological properties of the prepared microspheres was investigated. Results showed that stable emulsification of oil in water (o/w) was achieved with a 5 wt% PCL. A decrease in particle size was observed for the PCL microspheres prepared by chloroform (19.02±6.41 μm) compared to the microspheres obtained by dichloromethane (59.81±23 μm) under the same conditions. Results also revealed that the addition of graphene changed the morphology and particle size of the microspheres significantly. Hollow PCL microspheres were obtained in the presence of graphene nanopowders when chloroform was utilized as the solvent. Drug release experiments indicated that hollow PCL-graphene composite microspheres have improved release behavior compared to bare solid PCL microspheres. The particles prepared in the study have the potential to be used in drug delivery and tissue engineering applications. © BME-PT.
dc.identifier.DOI-ID10.3144/EXPRESSPOLYMLETT.2021.54
dc.identifier.issn1788618X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13606
dc.language.isoEnglish
dc.publisherBME-PT and GTE
dc.rightsAll Open Access; Bronze Open Access
dc.subjectControlled drug delivery
dc.subjectDichloromethane
dc.subjectEmulsification
dc.subjectEvaporation
dc.subjectGraphene
dc.subjectNanostructured materials
dc.subjectOrganic solvents
dc.subjectParticle size
dc.subjectTargeted drug delivery
dc.subjectTissue engineering
dc.subjectEffect of solvents
dc.subjectGraphene composites
dc.subjectOil-in-water (o/w) emulsion
dc.subjectPolyvinyl alcohol solution
dc.subjectRelease behaviors
dc.subjectSingle emulsions
dc.subjectStructural and morphological properties
dc.subjectTissue engineering applications
dc.subjectMicrospheres
dc.titlePreparation of hollow pcl microspheres by o/w single emulsion-solvent evaporation method in the presence of graphene nanopowders
dc.typeArticle

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