Synthesis and cytotoxic activities of organometallic Ru(II) diamine complexes

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dc.contributor.authorKavukcu S.B.
dc.contributor.authorŞahin O.
dc.contributor.authorSeda Vatansever H.
dc.contributor.authorKurt F.O.
dc.contributor.authorKorkmaz M.
dc.contributor.authorKendirci R.
dc.contributor.authorPelit L.
dc.contributor.authorTürkmen H.
dc.date.accessioned2024-07-22T08:07:20Z
dc.date.available2024-07-22T08:07:20Z
dc.date.issued2020
dc.description.abstractA series of mono and bimetallic ruthenium(II) arene complexes bearing diamine (Ru1-6) were prepared and fully characterized by 1H, 13C, 19F, and 31P NMR spectroscopy and elemental analysis. The crystal structure of the bimetallic complex (Ru5) was determined by X-ray crystallography. Monometallic analogues (Ru1-3) were synthesized to investigate the contributions of ruthenium and the other organic groups (aren, ethylenediamine, butyl) to the activity. The electrochemical behaviors of mono and bimetallic complexes were obtained from the relationship between cyclic voltammetry (CV) and the biological activities of the compounds. The cytotoxic activities of the complexes (Ru1-6) were tested against wide-scale cancer cell lines, namely HeLa, MDA-MB-231, DU-145, LNCaP, Hep-G2, Saos-2, PC-3, and MCF-7, and normal cell lines 3T3-L1 and Vero. Diamine Ru(II) arene complexes have unique biological characteristics and they are promising models for new anticancer drug development. MTT analysis reveals that each synthesized Ru complex showed cytotoxic activity towards the different cancer cells. In particular, three Ru complexes (Ru3, Ru5 and Ru6) showed less toxic effects on the cancer cells than the others. These novel Ru complexes affected both cancer and normal cell lines. As they had a toxic effect on the cells, the dosage applied should be tested before being used for in vivo applications. Cytotoxicity tests have shown that the bimetallic complex Ru6 was effective on all cancer cells. The effect of bimetallic enhancement on cancer cell lines, the systematic variation of the intermetallic distance and the ligand donor properties of the mono and bimetallic complexes were explored based on the cytotoxic activity. The interaction with FS-DNA and the stability/aquation of the complexes (Ru3 and Ru6) were investigated with 1H NMR spectroscopy. The binding modes between the complexes (Ru3 and Ru6) and DNA were investigated via UV–Vis spectroscopy. © 2020 Elsevier Inc.
dc.identifier.DOI-ID10.1016/j.bioorg.2020.103793
dc.identifier.issn00452068
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13930
dc.language.isoEnglish
dc.publisherAcademic Press Inc.
dc.subject3T3-L1 Cells
dc.subjectAnimals
dc.subjectAntineoplastic Agents
dc.subjectCell Proliferation
dc.subjectCells, Cultured
dc.subjectChlorocebus aethiops
dc.subjectDiamines
dc.subjectDose-Response Relationship, Drug
dc.subjectDrug Screening Assays, Antitumor
dc.subjectHumans
dc.subjectMice
dc.subjectMolecular Structure
dc.subjectOrganometallic Compounds
dc.subjectRuthenium
dc.subjectStructure-Activity Relationship
dc.subjectVero Cells
dc.subjectcytotoxic agent
dc.subjectdiamine derivative
dc.subjectorganometallic compound
dc.subjectruthenium complex
dc.subjectantineoplastic agent
dc.subjectdiamine
dc.subjectorganometallic compound
dc.subjectruthenium
dc.subject3T3-L1 cell line
dc.subjectA-549 cell line
dc.subjectA2780 cell line
dc.subjectArticle
dc.subjectcarbon nuclear magnetic resonance
dc.subjectcontrolled study
dc.subjectcrystal structure
dc.subjectcyclic voltammetry
dc.subjectDNA binding
dc.subjectdrug cytotoxicity
dc.subjectdrug synthesis
dc.subjectDU145 cell line
dc.subjectelemental analysis
dc.subjectfemale
dc.subjectfluorine nuclear magnetic resonance
dc.subjectHeLa cell line
dc.subjectHep-G2 cell line
dc.subjecthuman
dc.subjecthuman cell
dc.subjectIC50
dc.subjectin vitro study
dc.subjectLNCaP cell line
dc.subjectmale
dc.subjectMCF-7 cell line
dc.subjectMDA-MB-231 cell line
dc.subjectMTT assay
dc.subjectoxidation reduction reaction
dc.subjectPC-3 [Human prostate carcinoma] cell line
dc.subjectphosphorus nuclear magnetic resonance
dc.subjectpriority journal
dc.subjectproton nuclear magnetic resonance
dc.subjectSaOS-2 cell line
dc.subjectultraviolet visible spectroscopy
dc.subjectVero cell line
dc.subjectX ray crystallography
dc.subjectanimal
dc.subjectcell culture
dc.subjectcell proliferation
dc.subjectchemical structure
dc.subjectchemistry
dc.subjectChlorocebus aethiops
dc.subjectdose response
dc.subjectdrug effect
dc.subjectdrug screening
dc.subjectmouse
dc.subjectstructure activity relation
dc.subjectsynthesis
dc.titleSynthesis and cytotoxic activities of organometallic Ru(II) diamine complexes
dc.typeArticle

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