Comparison of Nephron-protective Effects of Enalapril and GLP Analogues (Exenatide) in Diabetic Nephropathy
| dc.contributor.author | Çavusoglu, T | |
| dc.contributor.author | Erbas, O | |
| dc.contributor.author | Karadeniz, T | |
| dc.contributor.author | Akdemir, O | |
| dc.contributor.author | Acikgoz, E | |
| dc.contributor.author | Karadeniz, M | |
| dc.contributor.author | Tuglu, MI | |
| dc.contributor.author | Ates, U | |
| dc.date.accessioned | 2025-04-10T10:36:25Z | |
| dc.date.available | 2025-04-10T10:36:25Z | |
| dc.description.abstract | Background: One of the major concerns is a nephropathy in diabetes, which applies many different kinds of medicines. However, required level of the treatment of renal disease has not been achieved. Aim: To investigate and compare the effect of the enalapril and the exenatide on diabetic nephropathy in rats developed diabetes by streptozosin. Material and Methods: 32 male Sprague Dawley rats were divided into 4 groups: (1) Control, (2) Diabetic (DM), (3) DM + Enalapril, and (4) DM + exenatide groups. Then, the animals were euthanized and their blood samples were collected by cardiac puncture for blood glucose; blood urea nitrogen (BUN), creatinin, and nephrectomy were performed for histopathologic examination, and urine samples were taken on stick for proteinuria. Results: Administration of the enalapril or the exenatide in diabetic rats resulted in a significant reduction both fibronectin, induced nitric oxide synthase (i-NOS) expression in glomerular area and urine protein levels. It was shown that both of enalapril and exenatide protected the renal glomerulus more than diabetic group in the nephropathy histopathologically. Conclusion: The beneficial effects of enalapril and exenatide which reduces fibronectin, i-NOS expression and urine protein levels or increases recovery of glomerules, might be used for preventing the harmful effects of diabetic nephropathy. | |
| dc.identifier.e-issn | 1439-3646 | |
| dc.identifier.issn | 0947-7349 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/42264 | |
| dc.language.iso | English | |
| dc.title | Comparison of Nephron-protective Effects of Enalapril and GLP Analogues (Exenatide) in Diabetic Nephropathy | |
| dc.type | Article |