Synthesis and biodistribution of novel magnetic-poly(HEMA-APH) nanopolymer radiolabeled with iodine-131 and investigation its fate in vivo for cancer therapy

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dc.contributor.authorAvcibaşi U.
dc.contributor.authorAvcibaşi N.
dc.contributor.authorAkalin H.A.
dc.contributor.authorEdiz M.
dc.contributor.authorDemiroǧlu H.
dc.contributor.authorGümüşer F.G.
dc.contributor.authorÖzçalişkan E.
dc.contributor.authorTürkcan C.
dc.contributor.authorUygun D.A.
dc.contributor.authorAkgöl S.
dc.date.accessioned2024-07-22T08:18:08Z
dc.date.available2024-07-22T08:18:08Z
dc.date.issued2013
dc.description.abstractHerein, we investigated the biological uptake, distribution, and radiopharmaceutical potential of a novel molecule based on 2-hydroxyethyl methacrylate (HEMA) and anilinephtalein (APH) in the metabolism of Albino Wistar rats. In order to achieve this, we synthesized APH using organic synthesis methods and copolymerized APH with HEMA using a common polymerization method, surfactant-free emulsion polymerization. In the presence of Fe3O 4 particles, we obtained a new generation magnetic-nano-scale polymer, magnetic-poly(HEMA-APH). This new molecule was chemically identified and approved by several characterization methods using Fourier transform infrared spectroscopy, scanning electron microscope, energy dispersive X-ray spectroscopy, electron spin resonance, atomic force microscope, and Zeta particle-size analysis. To evaluate the biological activity in live metabolism and anti-cancer potential of mag-poly(HEMA-APH), molecule was radioiodinated by a widely used labeling technique, iodogen method, with a gamma diffuser radionuclide, 131I. Thin-layer radiochromatography experiments demonstrated that 131I binded to nanopolymer with the labeling yield of 90 %. Lipophilicity and stability experiments were conducted to determine the condition of cold and labeled mag-poly(HEMA-APH) in rat blood and lipid medium. Results demonstrated that radioiodinated molecule stayed as an intact complex in rat metabolism for 24 h and experimental lipophilicity was determined as 0.12 ± 0.02. In vivo results obtained by imaging and biological distribution experiments indicated that mag-poly(HEMA-APH) labeled with 131I [131I-mag-poly(HEMA-APH)] highly incorporated into tissues of the uterus, the ovarian, the prostate, and the lungs in rat metabolism. Based on these results, it may be evaluated that novel mag-poly(HEMA-APH) molecule labeled with 131I is a compound which has a significant potential for being used as an anti-cancer agent. Certain results can only be obtained whether this molecule is applied to adenocarcinoma cell models and tumor-bearing animals. © 2013 Springer Science+Business Media Dordrecht.
dc.identifier.DOI-ID10.1007/s11051-013-2021-7
dc.identifier.issn13880764
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17209
dc.language.isoEnglish
dc.publisherKluwer Academic Publishers
dc.subjectAniline
dc.subjectAtomic force microscopy
dc.subjectBioactivity
dc.subjectChromatography
dc.subjectDiseases
dc.subjectDrug delivery
dc.subjectEmulsification
dc.subjectEmulsion polymerization
dc.subjectEnergy dispersive spectroscopy
dc.subjectFourier transform infrared spectroscopy
dc.subjectIodine
dc.subjectIron oxides
dc.subjectMagnetic moments
dc.subjectMagnetite
dc.subjectMedical nanotechnology
dc.subjectMetabolism
dc.subjectMolecules
dc.subjectNanomagnetics
dc.subjectParticle size
dc.subjectParticle size analysis
dc.subjectRats
dc.subjectScanning electron microscopy
dc.subjectmagnetic poly 2 hydroxyethyl methacrylate anilinephtalein i 131
dc.subjectradiopharmaceutical agent
dc.subjectunclassified drug
dc.subjectAnilinephtalein
dc.subjectCancer therapeutics
dc.subjectIodine-131
dc.subjectNano polymers
dc.subjectPoly(HEMA)
dc.subjectanimal experiment
dc.subjectantineoplastic activity
dc.subjectarticle
dc.subjectbiological activity
dc.subjectcancer chemotherapy
dc.subjectdrug distribution
dc.subjectdrug metabolism
dc.subjectdrug synthesis
dc.subjectdrug uptake
dc.subjectelectron microscope
dc.subjectelectron spin resonance
dc.subjectfemale
dc.subjectin vivo study
dc.subjectinfrared spectroscopy
dc.subjectisotope labeling
dc.subjectlipophilicity
dc.subjectmale
dc.subjectnonhuman
dc.subjectparticle size
dc.subjectpriority journal
dc.subjectradiochromatography
dc.subjectrat
dc.subjectzeta potential
dc.subjectElectron spin resonance spectroscopy
dc.titleSynthesis and biodistribution of novel magnetic-poly(HEMA-APH) nanopolymer radiolabeled with iodine-131 and investigation its fate in vivo for cancer therapy
dc.typeArticle

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