Assessment of PSA-Age volume score in predicting positive prostate biopsy findings in Turkey

Uçer O.; Yücetas U.; Çelen I.; Toktas G.; Müezzinoglu T.

Assessment of PSA-Age volume score in predicting positive prostate biopsy findings in Turkey

Date

2015

Authors

Publisher

Brazilian Society of Urology

Abstract

Objectives: To evaluate PSA-age volume (AV) scores in predicting positive prostate biopsy findings in Turkey. Materials and Methods: PSA-AV was calculated by multiplying the patient's age by the prostate volume and dividing it by the PSA level. Sensitivities and specificities of the PSA-AV were assessed by retrospective analysis of findings from 4,717 prostate biopsies. Results: The population's average age was 63.71±7.63 years, the mean PSA level was 9.73±17.01ng/mL, the mean prostate volume was 44.46±23.88 cm3. Of the 4,717 prostate biopsies, 1,171 biopsy specimens (24.8%) were positive for prostate cancer. A PSA- -AV score of 700 had a sensitivity and specificity of 95% and 15%, respectively. These values were similar to the sensitivity and specificity for a PSA cut-offof 4ng/mL (94% and 13%, respectively). Although the sensitivity of a PSA-AV cut-offof 700 in patients over 60 years was similar to the PSA cut-offof 4ng/mL and the age-adjusted PSA, in patients <60 years, its sensitivity was higher. While the sensitivities of a PSA-AV cut- -offof 700 in patients with low prostate volume was higher than a PSA cut-offof 4ng/mL, the sensitivities of both methods with moderate prostate volumes were similar. Conclusions: Considering all the biopsies, the sensitivity and specificity of a PSA-AV of 700 for predicting positive biopsy findings were similar to a PSA of 4ng/mL. We suggest the PSA-AV cut-offof 700 should only be used in patients younger than 60 with low prostate volumes (<20cm3).