Assessment of neuromuscular and haemodynamic effects of cisatracurium and vecuronium under sevoflurane-remifentanil anaesthesia in elderly patients

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dc.contributor.authorKeleş G.T.
dc.contributor.authorYentür A.
dc.contributor.authorÇavuş Z.
dc.contributor.authorSakarya M.
dc.date.accessioned2024-07-22T08:24:22Z
dc.date.available2024-07-22T08:24:22Z
dc.date.issued2004
dc.description.abstractBackground and objective: Neuromuscular block times, quality of muscle relaxation for tracheal tube insertion, and the haemodynamic effects after cisatracurium and vecuronium under sevoflurane-remifentanil anaesthesia were compared in elderly patients. Methods: The study was performed in 40 patients over 65 yr of age. Anaesthesia was induced with thiopental, and maintained with sevoflurane in N2O/O2 and remifentanil. Cisatracurium 0.15 mg kg-1 or vecuronium 0.1 mg kg-1 were administered after induction. Intubation was attempted when neuromuscular block was 95%. Onset time, clinical duration of action, recovery index, spontaneous recovery time and tracheal intubation conditions were assessed. Haemodynamic parameters were also monitored. Results: The average ages of the patients were 72.5 ± 5.1 and 73.6 ± 6.3 in the cisatracurium and vecuronium groups, respectively. Onset time was significantly shorter after vecuronium, 158 ± 34s vs. 200 ± 50s, respectively. Recovery index was significantly shorter after cisatracurium, 19.5 ± 7.5s vs. 33.7 ± 18.6s (P < 0.05). Clinical duration and spontaneous recovery time were similar in both groups as well as haemodynamic variables. Conclusions: In elderly patients, vecuronium has a faster onset time while cisatracurium has a shorter recovery index under sevoflurane-remifentanil anaesthesia.
dc.identifier.DOI-ID10.1017/S0265021504000225
dc.identifier.issn02650215
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19954
dc.language.isoEnglish
dc.subjectAged
dc.subjectAnesthesia Recovery Period
dc.subjectAnesthetics, Inhalation
dc.subjectAnesthetics, Intravenous
dc.subjectAtracurium
dc.subjectBlood Pressure
dc.subjectDouble-Blind Method
dc.subjectFemale
dc.subjectHeart Rate
dc.subjectHemodynamic Processes
dc.subjectHumans
dc.subjectIntubation, Intratracheal
dc.subjectMale
dc.subjectMethyl Ethers
dc.subjectMuscle Relaxation
dc.subjectNeuromuscular Blocking Agents
dc.subjectNeuromuscular Nondepolarizing Agents
dc.subjectPiperidines
dc.subjectTime Factors
dc.subjectVecuronium Bromide
dc.subjectcisatracurium
dc.subjectnitrous oxide
dc.subjectoxygen
dc.subjectremifentanil
dc.subjectsevoflurane
dc.subjectthiopental
dc.subjectvecuronium
dc.subjectaged
dc.subjectaging
dc.subjectanesthesia induction
dc.subjectarticle
dc.subjectclinical article
dc.subjectclinical trial
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectdisease course
dc.subjectdouble blind procedure
dc.subjectendotracheal intubation
dc.subjectgeneral anesthesia
dc.subjecthemodynamic monitoring
dc.subjecthemodynamic parameters
dc.subjecthemodynamics
dc.subjecthuman
dc.subjectmuscle relaxation
dc.subjectneuromuscular blocking
dc.subjectrandomized controlled trial
dc.titleAssessment of neuromuscular and haemodynamic effects of cisatracurium and vecuronium under sevoflurane-remifentanil anaesthesia in elderly patients
dc.typeArticle

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