In vitro anti-leishmanial activity of Sarcopoterium spinosum against Leishmania tropica; [Sarcopoterium spinosum’un Leishmania tropica’ya karşı in vitro anti-leishmanial etkisi]

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dc.contributor.authorCan H.
dc.contributor.authorKayalar H.
dc.contributor.authorBozkurt B.
dc.contributor.authorCan Ş.
dc.contributor.authorDöşkaya M.
dc.contributor.authorTöz S.
dc.date.accessioned2024-07-22T08:10:08Z
dc.date.available2024-07-22T08:10:08Z
dc.date.issued2018
dc.description.abstractComplex clinical symptoms such as ulcerative skin lesions, destructive mucosal inflammation, and disseminated visceral infection can reveal in leishmaniasis. The conventional drugs are toxic and expensive. In addition, patients receive a long treatment with these drugs which have adverse effects and unfortunately there are some limitations during the treatment. The aim of this study is to investigate the in vitro anti-leishmanial activities of four different extracts of Sarcopoterium spinosum against Leishmania tropica. Initially, different concentrations of ethanol, methanol, n-hexane, and water extracts of S. spinosum were incubated with L. tropica promastigotes. After 72 hours of incubation, the growth of L. tropica promastigotes was significantly inhibited and the percentage of inhibition ranged between 42.8 and 100 %. Among these extracts, the most efficient growth inhibition (100 %) was obtained with methanol extract (at a dose of 50 µg/ml). In conclusion, S. spinosum may be a potential source for the development of novel therapeutic agents to treat L. tropica infection. © 2018, Chartered Inst. of Building Services Engineers. All rights reserved.
dc.identifier.DOI-ID10.1501/Vetfak_0000002870
dc.identifier.issn13000861
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15083
dc.language.isoEnglish
dc.publisherChartered Inst. of Building Services Engineers
dc.rightsAll Open Access; Bronze Open Access
dc.subjectalcohol
dc.subjectalkaloid
dc.subjectantileishmanial agent
dc.subjectflavonoid
dc.subjecthexane
dc.subjectmethanol
dc.subjectsarcopoterium spinosum extract
dc.subjecttannin
dc.subjecttriterpenoid
dc.subjectunclassified drug
dc.subjectanalysis of variance
dc.subjectArticle
dc.subjectcontrolled study
dc.subjectgrowth inhibition
dc.subjectgrowth rate
dc.subjectIC50
dc.subjectin vitro study
dc.subjectincubation temperature
dc.subjectleishmaniasis
dc.subjectmorphology
dc.subjectnonhuman
dc.subjectphytochemistry
dc.subjectpromastigote
dc.subjectskin defect
dc.subjecttherapy effect
dc.subjecttoxicity testing
dc.subjectzone of inhibition
dc.titleIn vitro anti-leishmanial activity of Sarcopoterium spinosum against Leishmania tropica; [Sarcopoterium spinosum’un Leishmania tropica’ya karşı in vitro anti-leishmanial etkisi]
dc.typeArticle

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