The long-term effect of mesh bioprosthesis in inguinal hernia repair on testicular nitric oxide metabolism and apoptosis in rat testis

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dc.contributor.authorTaneli F.
dc.contributor.authorAydede H.
dc.contributor.authorVatansever S.
dc.contributor.authorUlman C.
dc.contributor.authorAri Z.
dc.contributor.authorUyanik B.S.
dc.date.accessioned2024-07-22T08:23:47Z
dc.date.available2024-07-22T08:23:47Z
dc.date.issued2005
dc.description.abstractPolypropylene mesh is the most widely used material in inguinal hernia repair. Although polypropylene mesh is known as an inert material, it is experimentally proven that mesh generates a chronic inflammatory tissue reaction. The aim of the present study was to investigate the long-term effects of polypropylene mesh material used in inguinal hernia operations on testicular function, testicular nitric oxide (NO) metabolism and germ cell-specific apoptosis in rats. The study comprised 40 male rats that were randomly allocated into two groups. In group 1, the left spermatic cord was elevated and a 0.5 × 1 cm polypropylene mesh was placed behind the left inguinal spermatic cord and group 2 consisted of the sham-operated controls. Blood samples were taken at 6 months preoperatively and postoperatively after to assess luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels for hormonal evaluation. Testicular NO was evaluated by the Griess method, apoptosis by a TUNEL method and inducible nitric oxide synthase (iNOS) and endothelial NOS (eNOS) expressions by immunohistochemical staining. Mild (+) eNOS expression was observed in all specimens. Mild (+) iNOS expression was only detected in ipsilateral testis of the mesh-implanted study group. Apoptotic cells were not detected in any samples. We are of the opinion that long-term polypropylene mesh implantation has no effect on testicular hormonal function and only a limited effect on nitric oxide levels and this effect is not sufficient to cause apoptosis in testis that could lead to infertility. It seems that mesh implantation is a reliable method in inguinal hernia repair; however, further work is required by more sensitive methods to fully elucidate the potential testicular damage. Copyright © 2004 John Wiley & Sons, Ltd.
dc.identifier.DOI-ID10.1002/cbf.1139
dc.identifier.issn02636484
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19674
dc.language.isoEnglish
dc.subjectAnimals
dc.subjectApoptosis
dc.subjectHernia, Inguinal
dc.subjectInfertility, Male
dc.subjectIschemia
dc.subjectMale
dc.subjectNitric Oxide
dc.subjectPostoperative Complications
dc.subjectProstheses and Implants
dc.subjectRats
dc.subjectRats, Inbred Strains
dc.subjectSpermatogenesis
dc.subjectSurgical Mesh
dc.subjectTestis
dc.subjectbiomaterial
dc.subjectendothelial nitric oxide synthase
dc.subjectfollitropin
dc.subjectinducible nitric oxide synthase
dc.subjectluteinizing hormone
dc.subjectnitric oxide
dc.subjectpolypropylene
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectapoptosis
dc.subjectarticle
dc.subjectbioprosthesis
dc.subjectblood sampling
dc.subjectchronic inflammation
dc.subjectcontrolled study
dc.subjectgerm cell
dc.subjectimmunohistochemistry
dc.subjectinguinal hernia
dc.subjectmale
dc.subjectmale infertility
dc.subjectmetabolism
dc.subjectnick end labeling
dc.subjectnonhuman
dc.subjectpostoperative period
dc.subjectpreoperative period
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjectrat
dc.subjectspermatic cord
dc.subjectsurgical equipment
dc.subjectsurgical technique
dc.subjecttestis
dc.subjecttestis function
dc.titleThe long-term effect of mesh bioprosthesis in inguinal hernia repair on testicular nitric oxide metabolism and apoptosis in rat testis
dc.typeArticle

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