Low levels of urinary epidermal growth factor predict chronic kidney disease progression in children

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dc.contributor.authorAzukaitis K.
dc.contributor.authorJu W.
dc.contributor.authorKirchner M.
dc.contributor.authorNair V.
dc.contributor.authorSmith M.
dc.contributor.authorFang Z.
dc.contributor.authorThurn-Valsassina D.
dc.contributor.authorBayazit A.
dc.contributor.authorNiemirska A.
dc.contributor.authorCanpolat N.
dc.contributor.authorBulut I.K.
dc.contributor.authorYalcinkaya F.
dc.contributor.authorParipovic D.
dc.contributor.authorHarambat J.
dc.contributor.authorCakar N.
dc.contributor.authorAlpay H.
dc.contributor.authorLugani F.
dc.contributor.authorMencarelli F.
dc.contributor.authorCivilibal M.
dc.contributor.authorErdogan H.
dc.contributor.authorGellermann J.
dc.contributor.authorVidal E.
dc.contributor.authorTabel Y.
dc.contributor.authorGimpel C.
dc.contributor.authorErtan P.
dc.contributor.authorYavascan O.
dc.contributor.authorMelk A.
dc.contributor.authorQuerfeld U.
dc.contributor.authorWühl E.
dc.contributor.authorKretzler M.
dc.contributor.authorSchaefer F.
dc.contributor.authorArbeiter K.
dc.contributor.authorRosales A.
dc.contributor.authorDusek J.
dc.contributor.authorZaloszyc A.
dc.contributor.authorLiebau M.
dc.contributor.authorWeber L.
dc.contributor.authorMuschiol E.
dc.contributor.authorBüscher R.
dc.contributor.authorOh J.
dc.contributor.authorThurn-Valassina D.
dc.contributor.authorHaffner D.
dc.contributor.authorJohn U.
dc.contributor.authorWygoda S.
dc.contributor.authorJeck N.
dc.contributor.authorWigger M.
dc.contributor.authorTesta S.
dc.contributor.authorMurer L.
dc.contributor.authorMatteucci C.
dc.contributor.authorJankauskiene A.
dc.contributor.authorDrozdz D.
dc.contributor.authorZurowska A.
dc.contributor.authorZaniew M.
dc.contributor.authorLitwin M.
dc.contributor.authorNimierska A.
dc.contributor.authorTeixeira A.
dc.contributor.authorPeco-Antic A.
dc.contributor.authorLaube G.
dc.contributor.authorAnarat A.
dc.contributor.authorDuzova A.
dc.contributor.authorBilginer Y.
dc.contributor.authorCaliskan S.
dc.contributor.authorMir S.
dc.contributor.authorSözeri B.
dc.contributor.authorKranz B.
dc.contributor.authorDorn B.
dc.contributor.authorBaskin E.
dc.contributor.authorSoylemezoglu O.
dc.contributor.authorEmre S.
dc.contributor.authorCandan C.
dc.contributor.authorKiyak A.
dc.contributor.authorOzcelik G.
dc.contributor.authorShroff R.
dc.contributor.authorRachin B.
dc.contributor.authorSzczepanska M.
dc.contributor.authorDonmez O.
dc.contributor.authorBalat A.
dc.contributor.authorAksu N.
dc.contributor.authorYilmaz E.
dc.contributor.authorBakkaloglu A.
dc.contributor.authorOzaltin F.
dc.contributor.authorSallay P.
dc.contributor.authorBonzel K.-E.
dc.contributor.authorWingen A.-M.
dc.contributor.authorBalasz I.
dc.contributor.authorTrivelli A.
dc.contributor.authorPerfumo F.
dc.contributor.authorMüller-Wiefel D.-E.
dc.contributor.authorMöller K.
dc.contributor.authorOffner G.
dc.contributor.authorEnke B.
dc.contributor.authorHadtstein C.
dc.contributor.authorMehls O.
dc.contributor.authorHohbach-Hohenfellner K.
dc.contributor.authorJeck N.
dc.contributor.authorKlaus G.
dc.contributor.authorArdissino G.
dc.contributor.authorMontini G.
dc.contributor.authorCharbit M.
dc.contributor.authorNiaudet P.
dc.contributor.authorAfonso A.C.
dc.contributor.authorFernandes-Teixeira A.
dc.contributor.authorPicca S.
dc.contributor.authorBerg U.B.
dc.contributor.authorCelsi G.
dc.contributor.authorFischbach M.
dc.contributor.authorTerzic J.
dc.contributor.authorFydryk J.
dc.contributor.authorUrasinski T.
dc.contributor.authorCoppo R.
dc.contributor.authorPeruzzi L.
dc.contributor.authorGrenda R.
dc.contributor.authorNeuhaus T.J.
dc.date.accessioned2024-07-22T08:08:31Z
dc.date.available2024-07-22T08:08:31Z
dc.date.issued2019
dc.description.abstractUrinary epidermal growth factor (uEGF) has recently been identified as a promising biomarker of chronic kidney disease (CKD) progression in adults with glomerular disease. Low levels of uEGF predict CKD progression and appear to reflect the extent of tubulointerstitial damage. We investigated the relevance of uEGF in pediatric CKD. We performed a post hoc analysis of the Cardiovascular Comorbidity in Children with CKD (4C) study, which prospectively follows children aged 6–17 years with baseline estimated glomerular filtration rate (eGFR) of 10–60 ml/min/1.73 m2. uEGF levels were measured in archived urine collected within 6 months of enrollment. Congenital abnormalities of the kidney and urinary tract were the most common cause of CKD, with glomerular diseases accounting for <10% of cases. Median eGFR at baseline was 28 ml/min/1.73 m2, and 288 of 623 participants (46.3%) reached the composite endpoint of CKD progression (50% eGFR loss, eGFR < 10 ml/min/1.73 m2, or initiation of renal replacement therapy). In a Cox proportional hazards model, higher uEGF/Cr was associated with a decreased risk of CKD progression (HR 0.76; 95% CI 0.69–0.84) independent of age, sex, baseline eGFR, primary kidney disease, proteinuria, and systolic blood pressure. The addition of uEGF/Cr to a model containing these variables resulted in a significant improvement in C-statistics, indicating better prediction of the 1-, 2- and 3-year risk of CKD progression. External validation in a prospective cohort of 222 children with CKD demonstrated comparable results. Thus, uEGF may be a useful biomarker to predict CKD progression in children with CKD. © 2019 International Society of Nephrology
dc.identifier.DOI-ID10.1016/j.kint.2019.01.035
dc.identifier.issn00852538
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14430
dc.language.isoEnglish
dc.publisherElsevier B.V.
dc.rightsAll Open Access; Hybrid Gold Open Access
dc.subjectAdolescent
dc.subjectAge Factors
dc.subjectBiomarkers
dc.subjectChild
dc.subjectDisease Progression
dc.subjectEpidermal Growth Factor
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectGlomerular Filtration Rate
dc.subjectHumans
dc.subjectMale
dc.subjectPredictive Value of Tests
dc.subjectProspective Studies
dc.subjectRenal Insufficiency, Chronic
dc.subjectRenal Replacement Therapy
dc.subjectRisk Factors
dc.subjectepidermal growth factor
dc.subjectbiological marker
dc.subjectepidermal growth factor
dc.subjectadolescent
dc.subjectArticle
dc.subjectchild
dc.subjectchronic kidney failure
dc.subjectcohort analysis
dc.subjectcomorbidity
dc.subjectcontrolled study
dc.subjectdisease course
dc.subjectestimated glomerular filtration rate
dc.subjectfemale
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpost hoc analysis
dc.subjectprediction
dc.subjectpriority journal
dc.subjectprospective study
dc.subjectprotein function
dc.subjectproteinuria
dc.subjectrenal replacement therapy
dc.subjectrisk factor
dc.subjectsystolic blood pressure
dc.subjecturinalysis
dc.subjectage
dc.subjectchronic kidney failure
dc.subjectdisease exacerbation
dc.subjectfollow up
dc.subjectglomerulus filtration rate
dc.subjectpathology
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjectpredictive value
dc.subjecturine
dc.titleLow levels of urinary epidermal growth factor predict chronic kidney disease progression in children
dc.typeArticle

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