Low levels of pro-resolving lipid mediators lipoxin-A4, resolvin-D1 and resolvin-E1 in patients with rheumatoid arthritis
No Thumbnail Available
Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier B.V.
Abstract
Rheumatoid arthritis (RA) is a disease in which joint inflammation is at the forefront but the whole body is affected, and prevention of inflammation is the main treatment approach. Lipoxins (LXs) and resolvins (Rvs) are critical molecules in the resolution of inflammation. In this study, we aimed to investigate the role of LXs and Rvs in the RA pathogenesis. To this end, we measured the LXA 4, RvD 1, RvE 1 levels, and inflammatory cytokines and chemokines IL-6, IL-8, IL-10, IL-17a, IL-22 and MCP-1 in patients with RA and healthy individuals. We found that the LXA4, RvD1, RvE1 levels of the active RA cases were significantly lower than in remission RA and healthy individuals, but the levels of inflammatory cytokines and chemokines were significantly higher. The decreases in LXs and Rvs were independent of disease activity, suggesting that there might be an impairment of LX and Rvs synthesis or catabolism in patients with RA. © 2020 European Federation of Immunological Societies
Description
Keywords
Adult, Aged, Arthritis, Rheumatoid, Cytokines, Disease Progression, Docosahexaenoic Acids, Eicosapentaenoic Acid, Female, Humans, Inflammation, Inflammation Mediators, Lipid Metabolism, Lipoxins, Male, Middle Aged, hydroxy fatty acid, interleukin 10, interleukin 17, interleukin 22, interleukin 6, interleukin 8, lipoxin A, monocyte chemotactic protein 1, resolvin D1, resolvin E1, unclassified drug, 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid, autacoid, cytokine, docosahexaenoic acid, icosapentaenoic acid, lipoxin, lipoxin A, resolvin D1, adult, Article, controlled study, disease activity, fatty acid metabolism, fatty acid synthesis, female, human, major clinical study, male, middle aged, pathogenesis, predictive value, priority journal, protein blood level, receiver operating characteristic, remission, rheumatoid arthritis, sensitivity and specificity, aged, disease exacerbation, inflammation, lipid metabolism, metabolism, rheumatoid arthritis