Predictive and prognostic factors for patients with locoregionally advanced laryngeal carcinoma treated with surgical multimodality protocol

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dc.contributor.authorEskiizmir G.
dc.contributor.authorTanyeri Toker G.
dc.contributor.authorCelik O.
dc.contributor.authorGunhan K.
dc.contributor.authorTan A.
dc.contributor.authorEllidokuz H.
dc.date.accessioned2024-07-22T08:10:51Z
dc.date.available2024-07-22T08:10:51Z
dc.date.issued2017
dc.description.abstractThe prognosis is suboptimal in patients with locoregionally advanced laryngeal carcinoma even after multimodality protocols. The purpose of this study was to determine the potential influential factors that have an impact on the development of locoregional recurrence, distant metastasis, and oncological outcomes in patients with locoregionally advanced laryngeal carcinoma who had surgical multimodality protocols. A sample size of 85 cases was determined based on a power of 90% and an effect size of α2 = 0.05. A retrospective analysis of 357 patients with a diagnosis of laryngeal cancer between 2002 and 2015 was performed. Eighteen variables based on sociodemographic, clinical, histopathological and treatment data were analyzed. Medical records of 85 consecutive patients with locoregionally advanced laryngeal carcinoma who underwent surgical multimodality protocols were reviewed. Five-year overall, disease-specific, disease-free, locoregional recurrence-free and distant metastasis-free survival were 68.7, 78.0, 69.6, 68.9 and 69.2%, respectively. Extracapsular extension was an independent predictive factor for locoregional recurrence. Pathologic tumor volume was an independent predictive factor for distant metastasis. pT-stage was an independent prognostic factor for 5-year overall survival, disease-free survival, locoregional recurrence-free survival and distant metastasis-free survival. High volume, pT4a laryngeal tumors with extracapsular extension are associated with a high risk of locoregional recurrence and distant metastasis; and have poor oncological outcomes in patients with locoregionally advanced laryngeal carcinoma treated with surgical multimodality protocols. © 2016, Springer-Verlag Berlin Heidelberg.
dc.identifier.DOI-ID10.1007/s00405-016-4411-9
dc.identifier.issn09374477
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15406
dc.language.isoEnglish
dc.publisherSpringer Verlag
dc.subjectAdult
dc.subjectAged
dc.subjectCarcinoma
dc.subjectCombined Modality Therapy
dc.subjectDisease-Free Survival
dc.subjectFemale
dc.subjectHumans
dc.subjectLaryngeal Neoplasms
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMultimodal Imaging
dc.subjectNeoplasm Recurrence, Local
dc.subjectPrognosis
dc.subjectRetrospective Studies
dc.subjectcisplatin
dc.subjectadvanced cancer
dc.subjectArticle
dc.subjectcancer patient
dc.subjectcancer prognosis
dc.subjectcancer radiotherapy
dc.subjectcancer recurrence
dc.subjectcancer size
dc.subjectcancer staging
dc.subjectcancer surgery
dc.subjectcancer survival
dc.subjectdisease free survival
dc.subjectdisease specific survival
dc.subjectdistant metastasis
dc.subjectdistant metastasis free survival
dc.subjecteffect size
dc.subjectfemale
dc.subjecthuman
dc.subjectlaryngectomy
dc.subjectlarynx carcinoma
dc.subjectlocal recurrence free survival
dc.subjectlymph node metastasis
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmultimodality cancer therapy
dc.subjectneck dissection
dc.subjectoverall survival
dc.subjectpriority journal
dc.subjectretrospective study
dc.subjectsurvival rate
dc.subjectsurvival time
dc.subjecttreatment outcome
dc.subjectadult
dc.subjectaged
dc.subjectcarcinoma
dc.subjectepidemiology
dc.subjectLaryngeal Neoplasms
dc.subjectmiddle aged
dc.subjectmortality
dc.subjectmultimodal imaging
dc.subjectmultimodality cancer therapy
dc.subjectprognosis
dc.subjecttumor recurrence
dc.titlePredictive and prognostic factors for patients with locoregionally advanced laryngeal carcinoma treated with surgical multimodality protocol
dc.typeArticle

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