Basal and activational tcm-hmpao brain spect in alzheimer's disease

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dc.contributor.authorSAYIT E.
dc.contributor.authorYENER G.
dc.contributor.authorÇAPA G.
dc.contributor.authorERTAY T.
dc.contributor.authorKESKIN B.
dc.contributor.authorFADILOĞLU S.
dc.contributor.authorDURAK H.
dc.date.accessioned2024-07-22T08:25:37Z
dc.date.available2024-07-22T08:25:37Z
dc.date.issued2000
dc.description.abstractEarly diagnosis in Alzheimer's disease (AD) is important for the administration of new treatments. The purpose of this study was to differentiate mildly/moderately demented AD patients from normal controls by means of activational brain SPECT, and to investigate the correlation between regional cerebral blood flow and dementia severity. Activational brain SPECT was performed 1 week after basal brain SPECT in 12 mild/moderate AD patients according to NINCDS-ADRDA criteria (mean age 69±7 years) and in seven healthy, age-matched, volunteer controls (mean age 65±9 years). In order to activate the parietal cortex, patients were asked to subtract serial 5's from 100, 2 min before and after the intravenous administration of 925 MBq technetium-99m labelled D,L-hexamethyl-propylene amine oxime (Tcm-HMPAO). Using a three-headed gamma camera equipped with high resolution collimators, 128 images of 35 s duration in a 64×64 matrix were obtained over 360°. Region to whole brain ratios (R/WB) were calculated in three consecutive transaxial slices 2 pixels thick above the orbitomeatal line, and the activation percentage was calculated. No statistical difference was detected between AD patients and normal controls for parietal cortex activation. The correlation coefficient between the Mini-Mental State Examination (MMSE) scoring and the activation percentage was 0.475 in normal controls and 0.175 in AD patients for the left anterior parietal cortex, and 0.353 in normal controls and 0.146 in AD patients for the right anterior parietal cortex. In a visual evaluation of parietal cortex activation, 50% of AD patients were able to activate the parietal cortex, whereas 86% of the normal controls could do so. In our current study, the subtraction of serial 5's was not regarded as a promising task. Further studies are needed to clarify the importance of such tasks in the differential diagnosis of mild/moderate AD patients from normal elderly. © 2000 Lippincott Williams & Wilkins, Inc.
dc.identifier.DOI-ID10.1097/00006231-200008000-00010
dc.identifier.issn01433636
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20512
dc.language.isoEnglish
dc.subjectAged
dc.subjectAlzheimer Disease
dc.subjectBrain
dc.subjectFemale
dc.subjectHumans
dc.subjectImage Processing, Computer-Assisted
dc.subjectMagnetic Resonance Imaging
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNeuropsychological Tests
dc.subjectParietal Lobe
dc.subjectRadiopharmaceuticals
dc.subjectTechnetium Tc 99m Exametazime
dc.subjectTomography, Emission-Computed, Single-Photon
dc.subjectTomography, X-Ray Computed
dc.subjectdiagnostic agent
dc.subjecthexamethylpropylene amine oxime technetium tc 99m
dc.subjectradiopharmaceutical agent
dc.subjectaged
dc.subjectAlzheimer disease
dc.subjectarticle
dc.subjectbrain
dc.subjectclinical trial
dc.subjectcomputer assisted tomography
dc.subjectfemale
dc.subjecthuman
dc.subjectimage processing
dc.subjectmale
dc.subjectmiddle aged
dc.subjectneuropsychological test
dc.subjectnuclear magnetic resonance imaging
dc.subjectparietal lobe
dc.subjectpsychological aspect
dc.subjectscintiscanning
dc.subjectsingle photon emission computer tomography
dc.titleBasal and activational tcm-hmpao brain spect in alzheimer's disease
dc.typeArticle

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