Clinical significance of lung perfusion defects in children with post-infectious bronchiolitis obliterans

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dc.contributor.authorYüksel H.
dc.contributor.authorYilmaz Ö.
dc.contributor.authorÜrk V.
dc.contributor.authorYüksel D.
dc.contributor.authorGöktan C.
dc.contributor.authorSavaş R.
dc.contributor.authorSayit E.
dc.date.accessioned2024-07-22T08:21:24Z
dc.date.available2024-07-22T08:21:24Z
dc.date.issued2009
dc.description.abstractClinical significance of segmental lung perfusion defects in children with bronchiolitis obliterans (BO), have not been reported before. The aim of this study was to evaluate clinical significance of lung perfusion defects in children with BO and to reveal its impact on follow up. The study included 38 children aged 9 to 60 months (17.8 ± 13.4 months) with BO. Diagnosis was based on persistent respiratory findings beyond six weeks and oligemic-mosaic pattern in lung high resolution computerized tomography. Chest X-ray, 24 hour esophageal pH monitoring, sweat chloride test, immunoglobulin levels and respiratory viral screening were carried out in all. Lung perfusion scintigraphy was carried out at least three months after the first clinical sign of BO. Perfusion defects were scored. Scintigraphy demonstrated perfusion defects in 24 (63.2%) patients but was normal in 14 (36.8%). Number of segments having perfusion defects was 2.9 ± 2.6. Mean number of exacerbations and days of hospitalization during the first year of follow up were 4.7 ± 4.4 and 26.9 ± 29.8 respectively. It was detected that number of perfusion defects correlated significantly with the number of exacerbations and duration of hospitalization (r= 0.66 and p= 0.00). In conclusion, number and extent of segments with perfusion defects in lungs of children with BO are correlated with clinical severity. Therefore, evaluation of lung perfusion status may aid in clinical determination of disease severity and its follow-up.
dc.identifier.issn04941373
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18572
dc.language.isoEnglish
dc.subjectBronchiolitis Obliterans
dc.subjectChild, Preschool
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectHospitalization
dc.subjectHumans
dc.subjectInfant
dc.subjectLength of Stay
dc.subjectLung
dc.subjectMale
dc.subjectPrognosis
dc.subjectRadionuclide Imaging
dc.subjectSeverity of Illness Index
dc.subjectTomography, X-Ray Computed
dc.subjectVentilation-Perfusion Ratio
dc.subjectantibiotic agent
dc.subjectbudesonide
dc.subjectdexamethasone
dc.subjectdomperidone
dc.subjectimmunoglobulin
dc.subjectipratropium bromide
dc.subjectlansoprazole
dc.subjectprednisolone
dc.subjectsalbutamol
dc.subjectarticle
dc.subjectbronchiolitis obliterans
dc.subjectchild
dc.subjectchild hospitalization
dc.subjectchlamydiasis
dc.subjectclinical article
dc.subjectclinical evaluation
dc.subjectcomputer assisted tomography
dc.subjectcontrolled study
dc.subjectdisease duration
dc.subjectdisease exacerbation
dc.subjectdisease severity
dc.subjectesophageal pH monitoring
dc.subjectfemale
dc.subjectfollow up
dc.subjectgastroesophageal reflux
dc.subjecthuman
dc.subjectimmunoglobulin blood level
dc.subjectinfant
dc.subjectlung perfusion
dc.subjectlung scintiscanning
dc.subjectmale
dc.subjectpreschool child
dc.subjectscreening
dc.subjectthorax radiography
dc.titleClinical significance of lung perfusion defects in children with post-infectious bronchiolitis obliterans
dc.typeArticle

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