Urachal urothelial carcinoma diagnosed at a radical prostatectomy operation: A case report

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dc.contributor.authorNese N.
dc.contributor.authorKesici G.
dc.contributor.authorLekili M.
dc.contributor.authorIsisag A.
dc.date.accessioned2024-07-22T08:21:02Z
dc.date.available2024-07-22T08:21:02Z
dc.date.issued2010
dc.description.abstractBACKGROUND: Urachal carcinomas are rare tumors, and the majority of them are adenocarcinomas. Up to now, only 21 urachal urothelial carcinomas (UCas) have been reported. Here, we describe a case of high grade UCa arising from the urachal remnants. CASE: A 66-year-old man presented with voiding difficulties. Prostate specific antigen (PSA) was 5.46 ng/mL. Prostatic adenocarcinoma (PCa) (Gleason score 6) was diagnosed by needle biopsies. After the diagnosis of high grade, muscle invasive UCa with intact mucosa on frozen examination of the dome of bladder wall during the radical prostatectomy operation (RPO), partial cystectomy was performed. Microscopically, among the tumoral islands, cystic structures lined by cells with a benign appearance, which are considered urachal remnants, were noted. Cytokeratin 7 and high-molecular-weight cytokeratin were strongly positive, PSA and carcinoembryonic antigen were negative. Radiotherapy was given for both UCa and PCa. Six months after the diagnosis, an undifferentiated tumor was detected in a bladder transurethral resection specimen; thus, chemotherapy was given. After 1 course of chemotherapy, the patient was doing well. CONCLUSION: The origin of urachal carcinomas is usually obscured as it is a highly invasive carcinoma. The patient presented here was diagnosed incidentally during RPO. Although the stage was advanced, the tumor was detected before urachal remnants were destroyed. The treatment choice for urachal carcinomas is cystectomy. Adjuvant chemotherapy and radiotherapy are controversial. © Science Printers and Publishers, Inc.
dc.identifier.issn08846812
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18439
dc.language.isoEnglish
dc.subjectAdenocarcinoma
dc.subjectAged
dc.subjectCarcinoma, Transitional Cell
dc.subjectCombined Modality Therapy
dc.subjectHumans
dc.subjectIncidental Findings
dc.subjectMale
dc.subjectNeoplasms, Multiple Primary
dc.subjectProstatectomy
dc.subjectProstatic Neoplasms
dc.subjectTreatment Outcome
dc.subjectUrachus
dc.subjectUrinary Bladder Neoplasms
dc.subjectUrothelium
dc.subjectUca
dc.subjectcarcinoembryonic antigen
dc.subjectcisplatin
dc.subjectcytokeratin
dc.subjectcytokeratin 7
dc.subjectgemcitabine
dc.subjecthigh molecular weight cytokeratin
dc.subjectprostate specific antigen
dc.subjectunclassified drug
dc.subjectadipose tissue
dc.subjectaged
dc.subjectarticle
dc.subjectbladder wall
dc.subjectcancer combination chemotherapy
dc.subjectcancer diagnosis
dc.subjectcancer grading
dc.subjectcancer invasion
dc.subjectcancer radiotherapy
dc.subjectcancer recurrence
dc.subjectcase report
dc.subjectcystectomy
dc.subjectcystoscopy
dc.subjectdetrusor muscle
dc.subjectfrozen section
dc.subjectGleason score
dc.subjecthuman
dc.subjecthuman cell
dc.subjecthuman tissue
dc.subjectmale
dc.subjectmicroscopy
dc.subjectmicturition disorder
dc.subjectneedle biopsy
dc.subjectpriority journal
dc.subjectprostate adenocarcinoma
dc.subjectprostatectomy
dc.subjecttransurethral resection
dc.subjecttreatment outcome
dc.subjecttumor cell
dc.subjectundifferentiated carcinoma
dc.subjecturachal urothelial carcinoma
dc.subjecturinalysis
dc.subjecturogenital tract cancer
dc.titleUrachal urothelial carcinoma diagnosed at a radical prostatectomy operation: A case report
dc.typeArticle

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