Impact of renal function or folate status on altered plasma homocysteine levels in hypothyroidism

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dc.contributor.authorÖzmen B.
dc.contributor.authorÖzmen D.
dc.contributor.authorParildar Z.
dc.contributor.authorMutaf I.
dc.contributor.authorTurgan N.
dc.contributor.authorBayindir O.
dc.date.accessioned2024-07-22T08:23:26Z
dc.date.available2024-07-22T08:23:26Z
dc.date.issued2006
dc.description.abstractHyperhomocysteinemia is an independent risk factor for coronary, peripheral and cerebrovascular diseases. Moderately elevated total homocysteine (tHcy) levels have been reported in patients with overt hypothyroidism. Plasma tHcy concentration is affected by several physiological factors and is elevated under conditions of impaired folate and cobalamin status and in renal failure. The aim of this study was to assess plasma tHcy concentrations and to evaluate the role of potential determinants of plasma tHcy levels in hypothyroid patients. Fasting plasma tHcy, serum homocysteine-related vitamins folate and vitamin B12, serum cystatin C (CysC) and creatinine, were determined in 22 hypothyroid patients and compared with 25 healthy control subjects. Creatinine clearance (CCr) was calculated using the Cockroft-Gault formula. Plasma tHcy levels were determined by HPLC with fluorescence detection and serum CysC by automated particle enhanced immunoturbidimetry. Plasma tHcy, creatinine levels were significantly higher, and serum CysC levels, and creatinine clearance values were lower in hypothyroid patients than in control subjects. Folate levels were lower in hypothyroidic group compared to the control group. There were no differences in vitamin B12 levels between hypothyroid and control groups. Positive correlation was noted between tHcy and creatinine levels in hypothyroid patients (r = 0.596); however, an inverse correlation was found between tHcy and folate levels (r = -0.705) in hypothyroid patients. In conclusion, tHcy was increased in hypothyroidism, and this increase was more strongly associated with changes in serum folate than in serum creatinine and CysC, suggesting an altered folate status.
dc.identifier.DOI-ID10.1507/endocrj.53.119
dc.identifier.issn13484540
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19536
dc.language.isoEnglish
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAdult
dc.subjectAged
dc.subjectChromatography, High Pressure Liquid
dc.subjectCreatinine
dc.subjectCystatins
dc.subjectData Interpretation, Statistical
dc.subjectFemale
dc.subjectFolic Acid
dc.subjectHomocysteine
dc.subjectHumans
dc.subjectHypothyroidism
dc.subjectKidney
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNephelometry and Turbidimetry
dc.subjectVitamin B 12
dc.subjectcreatinine
dc.subjectcyanocobalamin
dc.subjectcystatin C
dc.subjectfolic acid
dc.subjecthomocysteine
dc.subjectadult
dc.subjectaged
dc.subjectarticle
dc.subjectcalculation
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectcorrelation analysis
dc.subjectcreatinine clearance
dc.subjectfemale
dc.subjectfluorescence
dc.subjecthigh performance liquid chromatography
dc.subjecthuman
dc.subjecthypothyroidism
dc.subjectkidney function
dc.subjectmale
dc.subjectturbidimetry
dc.titleImpact of renal function or folate status on altered plasma homocysteine levels in hypothyroidism
dc.typeArticle

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