Comparing the effects of two different doses of remifentanil infusion during induction; [Anestezi indüksiyonu sirasinda iki farkli dozda reṁifentanil infüzyonunun karşilaştirilmasi]

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dc.contributor.authorTezcan Keleş G.
dc.contributor.authorYentür E.A.
dc.contributor.authorSakarya M.
dc.contributor.authorToprak V.
dc.contributor.authorOk G.
dc.contributor.authorTaşyüz T.
dc.date.accessioned2024-07-22T08:25:13Z
dc.date.available2024-07-22T08:25:13Z
dc.date.issued2002
dc.description.abstractIn this study we compared the effects of two different doses of remifentanil infusion on haemodynamic variables and complications during the anesthesia induction. 50 patients, undergoing tympanoplasty operation were enrolled in this study. They were randomly divided into two groups. Before the anesthesia induction, bolus dose of 1 μg kg-1 remifentanil was administered to all patients. Immediately after, an infusion of remifentanil either 0.5 μg kg-1 min-1 min-1 (Grup I: n=25) or μg kg-1 min-1 (Grup II:n=25) was commanced. After three minutes 2 mg kg-1 propofol and 0.1 mg kg-1 vecuronium was administered before tracheal intubation. Anesthesia was maintained with 66 % N2O in O2 and 1.2 % (end tidal) sevoflurane and remifentanil infusion. Hemodynamic values (systolic, diastolic and mean arterial blood pressures and heart rate) and all adverse effects were recorded at 1 and 3 min after the initiation of infusion, before and after intubation, before and surgical incision. For the statistical analysis student's t-test and Mann Whitney -U tests were used. Results were considered significant when p<0.05. With regard to hemodynamic variables systolic, diastolic and mean arterial blood pressures were significantly lower in Group I and Group II three and one minutes after the initiation of remifentanil infusion respectively (p<0.05). Heart rates were significantly lower after the preintubation measurements in group I and after the third minute measurements at group II (p<0.05). There were no hemodynamic response to intubation and skin incision in both groups. At the induction, bradycardia was more prominent in Grup II than Grup I (p<0.05). We concluded that, higher doses of remifentanil did not effect the haemodynamics but lead an increase in adverse effects.
dc.identifier.issn13000578
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20326
dc.language.isoTurkish
dc.subjectnitrogen oxide
dc.subjectoxygen
dc.subjectpropofol
dc.subjectremifentanil
dc.subjectsevoflurane
dc.subjectvecuronium
dc.subjectanesthesia induction
dc.subjectarticle
dc.subjectbradycardia
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectdiastolic blood pressure
dc.subjectdose response
dc.subjectdrug effect
dc.subjectdrug infusion
dc.subjectendotracheal intubation
dc.subjectheart rate
dc.subjecthemodynamic parameters
dc.subjecthuman
dc.subjectmean arterial pressure
dc.subjectpostoperative period
dc.subjectrandomization
dc.subjectrank sum test
dc.subjectskin incision
dc.subjectstatistical analysis
dc.subjectStudent t test
dc.subjectsystolic blood pressure
dc.subjecttympanoplasty
dc.titleComparing the effects of two different doses of remifentanil infusion during induction; [Anestezi indüksiyonu sirasinda iki farkli dozda reṁifentanil infüzyonunun karşilaştirilmasi]
dc.typeArticle

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