Evaluation of psychosocial functioning in the acute treatment term of major depressive disorder: A 16-week multi-centered follow-up study

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dc.contributor.authorAltunsoy N.
dc.contributor.authorDi̇ki̇ci̇ D.S.
dc.contributor.authorÇökmüş F.P.
dc.contributor.authorÖzkan H.M.
dc.contributor.authorAşçibaşi K.
dc.contributor.authorAlçi D.
dc.contributor.authorKuru E.
dc.contributor.authorYüzeren S.
dc.contributor.authorAydemi̇r Ö.
dc.date.accessioned2024-07-22T08:05:23Z
dc.date.available2024-07-22T08:05:23Z
dc.date.issued2021
dc.description.abstractObjective: Major depressive disorder is the leading cause of non-fatal burden, and disability in adulthood. Even though depression is well-treated in the acute term,psychosocial functioning does not get back to the premorbid level most of the time. In this present study, it is aimed to evaluate the outcome of the acute term treatment of major depressive disorder in terms of psychosocial functioning. Methods: The study is an open-label, observational, multi-center follow-up study for four months of patients with major depressive disorder according to DSM-5. Patients were evaluated with Montgomery Asberg Depression Rating Scale (MADRS), Sheehan Disability Scale (SDS) and Short Form-36 (SF-36) at the beginning, and at the 2., 4., 8., 12. and 16.weeks. Results: 100 patients were invited to the study and 56 patients completed the study.As a result of the treatment, the mean MADRS and SDS scores decreased significantly. All domains of SF-36 were improved significantly with the treatment. Unfortunately patients suffering from MDD could not reach the normative data,especially on the domains of social functioning, role emotional, pain, and general health perception. Treatment outcomes show that SNRI users presented higher scores on the domains of pain and physical functioning. However SSRI users showed better outcomes on the domains of mental health and vitality. Conclusion: Our research corroborated that even patients gain symptomatic remission in MDD treatment, psychosocial dysfunction persists. It is also concluded that different antidepressant options may act differently on treatment outcomes. © 2021 Elsevier B.V.
dc.identifier.DOI-ID10.1016/j.ajp.2021.102883
dc.identifier.issn18762018
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13117
dc.language.isoEnglish
dc.publisherElsevier B.V.
dc.subjectAdult
dc.subjectAntidepressive Agents
dc.subjectDepressive Disorder, Major
dc.subjectDouble-Blind Method
dc.subjectFollow-Up Studies
dc.subjectHumans
dc.subjectPsychosocial Functioning
dc.subjectTreatment Outcome
dc.subjectserotonin noradrenalin reuptake inhibitor
dc.subjectserotonin uptake inhibitor
dc.subjectantidepressant agent
dc.subjectadult
dc.subjectArticle
dc.subjectclinical outcome
dc.subjectdrug use
dc.subjectDSM-5
dc.subjectemotion
dc.subjectevaluation study
dc.subjectfemale
dc.subjectfollow up
dc.subjectgeneral health perception
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmajor depression
dc.subjectmale
dc.subjectmental health
dc.subjectMontgomery Asberg Depression Rating Scale
dc.subjectobservational study
dc.subjectpain
dc.subjectperception
dc.subjectpersonality
dc.subjectquality of life
dc.subjectremission
dc.subjectSheehan Disability Scale
dc.subjectShort Form 36
dc.subjectsocial interaction
dc.subjectsocial psychology
dc.subjecttreatment outcome
dc.subjectvitality
dc.subjectclinical trial
dc.subjectdouble blind procedure
dc.subjectmulticenter study
dc.subjectsocial psychology
dc.titleEvaluation of psychosocial functioning in the acute treatment term of major depressive disorder: A 16-week multi-centered follow-up study
dc.typeArticle

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